121: Ter Arkh. 2007;79(6):25-30.



[Glomerular filtration rate is an indicator of endothelial function at early

stages of chronic kidney disease]



[Article in Russian]



Smirnov AV, Petrishchev NN, Panina IIu, Rumiantsev ASh, Degtereva OA, Tugusheva

FA, Menshutina MA.



AIM: To study effects of glomerular filtration rate (GFR) reduction on

endothelial function in patients at early stages of chronic renal kidney (CKD).

MATERIAL AND METHODS: Endothelial function of 101 patients with CKD of stage

I-III was examined using reactive hyperemia test, dopplerography of skin vessels 

with ionophoresis of acetylcholin and nitroglycerin, lipidogram parameters,

homocistein and annexin A5 levels, intima-media complex thickness of the common

carotid artery, echocardiography findings. RESULTS: Cardiovascular complications 

risk factors were found in all the patients: increased body mass index, arterial 

hypertension, dyslipoproteinemia, hyperhomocysteinemia. Reduced GFR (under 90

ml/min) is an independent factor of atherosclerosis risk. CONCLUSION: GFR

reduction corresponding to CRD of stage II is accompanied with enhancement of

apoptosis and development of vasomotor endothelial dysfunction that in

combination with risk factors contribute to development of a preclinical

atherosclerosis phase.



Publication Types: 

    English Abstract



Mesh Terms:

    Adult

    Annexins/blood

    Biological Markers/blood

    Cardiovascular Diseases/diagnosis

    Cardiovascular Diseases/etiology*

    Cardiovascular Diseases/physiopathology

    Carotid Artery, Common/physiopathology

    Carotid Artery, Common/ultrasonography

    Disease Progression

    Endothelium, Vascular/physiopathology*

    Female

    Glomerular Filtration Rate/physiology*

    Homocysteine/blood

    Humans

    Kidney Failure, Chronic/blood

    Kidney Failure, Chronic/complications

    Kidney Failure, Chronic/physiopathology*

    Male

    Middle Aged

    Prognosis

    Risk Factors

    Tunica Intima/ultrasonography

    Ultrasonography, Doppler



Substances:

    Annexins

    Biological Markers

    Homocysteine



PMID: 17684962 [PubMed - indexed for MEDLINE]



122: Klin Lab Diagn. 2007 Jun;(6):14-7.



[A procedure for determining the oxidative modification of apolipoproteins in

low-density lipoproteins]



[Article in Russian]



Ragino IuI, Polonskaia IaV, Sadovskiä­ EV.



The purpose of the present study was to develop a new procedure for estimating

the oxidative modification of apolipoproteins in low-density lipoproteins (LDLs).

The procedure was developed to use blood serum from 153 males aged 45-65 years,

including 69 patients with coronary angiography-verified coronary atherosclerosis

and 84 males from a representative sample from Novosibirsk residents of the same 

age. The new procedure is as follows: a rapid method for isolating serum LDLs,

their apolipoprotein (apoLP) protein measurement by the Lowry procedure, their

precipitation, a reaction with 2,4-dinitrophenylhydrazine in 2 M HCl solution, by

subsequently rinsing in the ethanol:ethyl acetate (1:1) solution, dissolving the 

precipitate in 8 M urea, and by determining the level of the resultant

dinitrophenylhydrazones by spectrophotometry at 363 nm, followed by conversion to

LDL concentration of apoLP. The procedure is of informative value for the degree 

of oxidative LDL modification of apoLP under oxidative stress; it is technically 

simple, takes little time, and shows a good reproducibility. The values of

determined oxidized LDL apoLP by the developed procedure highly positively

correlated with the estimates of an oxidized total blood protein fraction and

with the values of endothelial dysfunction and did not with the parameters of

blood LDL peroxidation. The detected elevated oxidation LDL apoLP in males with

coronary atherosclerosis suggests that this index is an additional marker of

potentially atherogenic LDL changes.



Publication Types: 

    English Abstract



Mesh Terms:

    Aged

    Apolipoproteins/blood*

    Biological Markers/blood

    Coronary Artery Disease/blood*

    Humans

    Lipoproteins, LDL/blood*

    Male

    Middle Aged

    Oxidation-Reduction

    Oxidative Stress*

    Protein Processing, Post-Translational*

    Reproducibility of Results

    Siberia

    Spectrophotometry, Ultraviolet



Substances:

    Apolipoproteins

    Biological Markers

    Lipoproteins, LDL



PMID: 17682473 [PubMed - indexed for MEDLINE]



123: Bioorg Khim. 2007 May-Jun;33(3):297-309.



[Oxysterols: genesis and basic functions]



[Article in Russian]



Antonchik AV, Zhabinskiä­ VN, Khripach VA.



The structural peculiarities of the most widespread oxysterols, the products of

oxidative transformations of cholesterol are discussed. The transformations

proceed with the participation of enzymatic systems of the body or as a result of

various nonenzymatic reactions. The pathways of their formation from cholesterol 

are also considered. The role of oxysterols in the maintenance of cholesterol

homeostasis and in the development of atherosclerosis is reviewed. The

possibility of using oxysterols as markers of pathological processes is

demonstrated.



Publication Types: 

    English Abstract

    Review



Mesh Terms:

    Animals

    Arteriosclerosis/metabolism

    Biological Markers/metabolism

    Biological Transport, Active

    Cholesterol/metabolism*

    Homeostasis

    Humans

    Hydroxycholesterols/chemistry

    Hydroxycholesterols/metabolism*

    Lipid Metabolism

    Liver/metabolism

    Oxidation-Reduction



Substances:

    Biological Markers

    Hydroxycholesterols

    Cholesterol



PMID: 17682385 [PubMed - indexed for MEDLINE]



124: Angiol Sosud Khir. 2007;13(1):152-5.



[Aneurysmal degeneration of the autovenous carotid-subclavian bypass: experience 

with the treatment, review of literature]



[Article in Russian]



Galkin PV, Mitroshin GE, Antonov GI, Miklashevich ER.



Tsentral'nyä­ Voennyä­ Klinicheskiä­ Gospital' im. A. A. Vishnevskogo, otdelenie

neä­rososudistoä­ khirurgii, Krasnogorsk, Rossiia.



The authors describe an experience gained with successful surgical treatment of a

73-year-old patient with a genuine aneurysm of the autoveinous carotid-subclavian

bypass, iwelve years ago the patient was operated on for stenosing

atherosclerosis of the coronary and left subclavian arteries (SCA). Aneurysm

emergence was consequent on the use of v.saphena magna as a bypass in the given

<<position>> and was not associated with appreciable circulatory disorders in the

left upper limb. However, its further existence was conjugated with the risk of

rupture and bleeding. Examination (duplex scanning, angiography) confirmed the

diagnosis of aneurysm. Besides, critical stenosis of segment I of the left SCA

and opening of the left internal carotid artery (ICA) were verified as well. The 

patient was operated on: the first stage involved angioplasty and stenting of

segment I of the left SCA; the second stage involved carotid endarterectomy on

the left, resection of bypass aneurysm together with its disengagement. On

control angiography performed 11 months later the patency of the reconstructed

arteries appeared satisfactory; stenosis was not recorded. The given case

demonstrates a modern approach to the treatment of patients with coexistent

vascular pathology (atherosclerotic stenosis plus aneurysm).



Publication Types: 

    English Abstract

    Review



Mesh Terms:

    Aged

    Arteriovenous Fistula/pathology*

    Arteriovenous Fistula/surgery*

    Carotid Arteries/surgery*

    Cerebral Revascularization/methods*

    Humans

    Male

    Subclavian Artery/surgery*



PMID: 17679988 [PubMed - indexed for MEDLINE]



125: Angiol Sosud Khir. 2007;13(1):25-30.



[Indices of antioxidant system of blood in differential diagnosis of obliterating

atherosclerosis and obliterating thromboangiitis of the lower limbs]



[Article in Russian]



Alukhanian OA, Abramov IuG, Korochanskaia SP.



Advanced Medical Training Department, Kuban State Medical Academy, Municipal

Clinical Hospital # 3, Krasnodar, Russia.



The work was aimed at elucidating the role of the indices of the antioxidant

system (AOS) of the blood and nitrogen oxide content in differential diagnosis of

atherosclerosis obiiterans (AO) and thromboangiitis obiiterans (TO) of the lower 

extremities. Presented herein are the findings of examining a total of one

hundred and thirteen 30-to-45-year-old patients (of these, 60 had TO and 53 had

AO) with various level of occlusion (from the femoropoplietal segment to the

aortoiliac zone) and the stage of chronic arterial insufficiency (CAI IIA-IV).

The control group was composed of 30 apparently healthy age-matched male

subjects. Besides the clinical, laboratory and special instrumental methods of

study, we determined the parameters of the AOS of blood and the content of

nitrogen oxide degradation products. It was determined that the directedness and 

pronouncedness of deviations in the parameters of the AOS and nitrogen oxide from

the physiological norm depended on not only the aetiology of the disease

involved, but on the degree of tissue hypoxia predetermined by the stage of CAI

of the lower limbs. For differential diagnosis between AO and TO, the most

informative should be considered the coefficient: SOD activity/catalase activity,

index of peroxide-luminol-dependent chemiluminescence and the content of nitrogen

oxide degradation products.



Publication Types: 

    English Abstract



Mesh Terms:

    Adult

    Antioxidants/metabolism*

    Arteriosclerosis Obliterans*/diagnosis

    Arteriosclerosis Obliterans*/metabolism

    Arteriosclerosis Obliterans*/physiopathology

    Biological Markers

    Catalase/metabolism

    Free Radicals/blood*

    Humans

    Male

    Middle Aged

    Nitrogen Dioxide/blood

    Thromboangiitis Obliterans*/diagnosis

    Thromboangiitis Obliterans*/metabolism

    Thromboangiitis Obliterans*/physiopathology



Substances:

    Antioxidants

    Biological Markers

    Free Radicals

    Nitrogen Dioxide

    Catalase



PMID: 17679972 [PubMed - indexed for MEDLINE]



126: Angiol Sosud Khir. 2007;13(1):17-23.



[Pathophysiological characteristics of microcirculatory disorders in chronic

arterial ischaemia of lower limbs]



[Article in Russian]



Kozlov VI, Azizov GA.



Russian University of Friendship of Peoples, Chair of Laser Medicine, Moscow,

Russia.



Presented herein are the findings of studying the peculiarities of the systemic

and regional haemodynamics in patients with obliterating atherosclerosis of the

arteries of the lower limbs. We examined a total of 186 patients with stage I-IV 

chronic arterial ischaemia of the lower extremities using the following methods: 

computer-assisted TV microscopy of the vessels of the conjunctiva of the eyeball 

and of the skin of the lower limbs, laser Doppler flowmetry (LDF) and

transcutaneous determination of oxygen tension. Revealed were: spastic,

congestive, Presented herein are the findings of studying the peculiarities of

the systemic and regional haemodynamics in patients with obliterating

atherosclerosis of the arteries of the lower limbs. We examined a total of 186

patients with stage I-IV chronic arterial ischaemia of the lower extremities

using the following methods: computer-assisted TV microscopy of the vessels of

the conjunctiva of the eyeball and of the skin of the lower limbs, laser Doppler 

flowmetry (LDF) and transcutaneous determination of oxygen tension. Revealed

were: spastic, congestive, spastic-atonic and stasic forms of microcirculatory

disorders. It was determined that microcirculatory disorders in obliterating

atherosclerosis of the lower limbs are systemic, to be revealed both in the

extremities affected and in the conjunctiva of the eyeball. A

pathophysiologically substantiated classification of microcirculatory disorders

is proposed herein.



Publication Types: 

    English Abstract



Mesh Terms:

    Adult

    Aged

    Chronic Disease

    Female

    Humans

    Ischemia/diagnosis

    Ischemia/physiopathology*

    Laser-Doppler Flowmetry

    Lower Extremity/blood supply*

    Lower Extremity/physiopathology*

    Male

    Microcirculation/physiology

    Middle Aged

    Severity of Illness Index



PMID: 17679971 [PubMed - indexed for MEDLINE]



127: Angiol Sosud Khir. 2006;12(4):127-32.



[Functional flowmetry in determining the indications for reconstructive surgical 

interventions on the major arteries of the pelvis and lower limbs]



[Article in Russian]



Kuznetsov MR, Koshkin VM, Rodionov SV, Virganskiä­ AO, Moskalenko EP, Golosnitskiä­

PY, Dobrianskiä­ MV.



State Educational Facility of Postgraduate Medical Training Russian State Medical

University, Moscow, Russia.



The work was based on the findings of the examination and surgical management of 

69 patients with obliterating atherosclerosis of the lower limbs with various

degree of chronic arterial insufficiency. The authors analyzed the main causes

promoting development of early reocclusion of the bypasses and prostheses

following reconstructive surgical operations. They also proved the role of high

peripheral vascular resistance and, in particular, diminished functional

possibilities of the microcirculatory-bed vessels in the genesis of early

reocclusions in patients with chronic arterial insufficiency of the lower limbs. 

They also suggested a new technique of determining the carrying capacity of the

microcirculatory channel, the use of which in the preoperative period makes it

possible to predict development of early thrombotic complications, and in some

cases to wisely abstain from carrying out a reconstructive vascular intervention 

due to high risk of its poor outcomes. It is preferable for such patients to

undergo conservative pathogenetic preoperative therapy aimed at improving the

functional possibilities of the microcirculatory vessels.



Publication Types: 

    English Abstract



Mesh Terms:

    Angiography

    Arterial Occlusive Diseases/diagnosis

    Arterial Occlusive Diseases/physiopathology*

    Arterial Occlusive Diseases/surgery

    Blood Flow Velocity/physiology*

    Female

    Humans

    Leg/blood supply*

    Male

    Middle Aged

    Pelvis/blood supply*

    Preoperative Care/methods*

    Prognosis

    Severity of Illness Index

    Ultrasonography, Doppler

    Vascular Resistance/physiology*

    Vascular Surgical Procedures/methods*



PMID: 17679966 [PubMed - indexed for MEDLINE]



128: Angiol Sosud Khir. 2006;12(4):11-5.



[Endothelial function and cellular morphology and functionality inischemic limbs 

during drug therapy of obliterative atherosclerosis]



[Article in Russian]



Katelnitskiä­ II, Pleskachev SA, Katelnitskiä­ II, Matsionis AS, Povilaä­tite PE.



Rostov State Medical University, Rostov-on-Don, Russia. katelnizkji@mail.ru



The aim of the study was to develop a rationale for Vasaprostan monotherapy of

ischemia in patients with obliterative lesions in lower limb arteries. The

assessment of blood cell ultrastructure revealed deformation of erythrocytes and 

platelets, aggregation of platelets and platelets with red cells, evidencing

severe rheological alterations and increased incidence of thrombotic events in

patients with critical ischemia. Vasaprostan monotherapy was more effective then 

combined therapy without prostaglandin E1. In patients with lower limb occlusive 

arterial lesions and different ischemic grades Vasaprostan alleviated endothelial

dysfunction and normalized different morphological and functional parameters of

erythrocytes and platelets. The trend toward ultrastructural normalization was

evident in all patients after Vasaprostan administration. This trend was proved

by changes in elemental composition of erythrocytes. CONCLUSION: Vasaprostan is

beneficial for patients with obliterative lesions in lower limb arteries and can 

be used as monotherapy or preoperative management for stimulation of volumetric

blood flow and blood supply of ischemic tissues.



Publication Types: 

    English Abstract



Mesh Terms:

    Atherosclerosis/complications*

    Atherosclerosis/drug therapy

    Blood Platelets/ultrastructure

    Endothelium, Vascular/physiopathology*

    Endothelium, Vascular/ultrastructure*

    Erythrocyte Deformability/drug effects

    Erythrocytes/drug effects

    Erythrocytes/ultrastructure

    Humans

    Ischemia/etiology*

    Ischemia/pathology

    Ischemia/physiopathology

    Leg/blood supply*

    Microscopy, Electron

    Platelet Aggregation/drug effects

    Treatment Outcome

    Vasodilation/drug effects*

    Vasodilator Agents/therapeutic use*



Substances:

    Vasodilator Agents



PMID: 17679953 [PubMed - indexed for MEDLINE]



129: Zh Evol Biokhim Fiziol. 2007 Mar-Apr;43(2):155-61.



[Content of the main lipid components in blood serum lipoproteins of human and of

various animal species]



[Article in Russian]



Lizenko MV, Regerand TI, Bakhirev AM, Petrovskiä­ VI, Lizenko EI.



Using precipitation method, low-density (LDL) and high-density (HDL2 and HDL3)

lipoproteins were isolated from blood serum of human (donors, patients with

ischemic heart) diseases--IHD, with bronchial asthma--BA, with chronic

obstructive bronchitis--COB), of mammals predisposed (pig, rabbit) and resistant 

(rat, mink, Arctic fox) to atherosclerosis, of birds (hen, pigeon), of bony fish 

(trout, white-fish, pike-perch, pike, bream, burbot), and of cartilaginous fish

(sturgeon, white sturgeon). From each lipoprotein group, lipids were extracted,

separated by thin-layer chromatography, and analyzed quantitatively by the

spectrophotometric method. In phosphatidylcholine and HDL2 cholesterol esters,

bound fatty acids (FA) were determined by the method of gas-liquid

chromatography. The main amount of total cholesterol has been established to be

concentrated in human LDL, especially in the cases of IHD, and in LDL in mammals 

predisposed to atherosclerosis. In mammals resistant to atherosclerosis and in

fish the almost entire cholesterol was revealed in HDL. The phospholipid content 

in HDL was lower in patients with pathologies and in mammals predisposed to

atherosclerosis, while the highest content--in fish and mammals resistant to

atherosclerosis. In homoiothermal animals and in human the main FA amount in HDL 

was represented by the omega6-series. Acids of the omega3-series amounted to a

negligible percentage, especially in IHD. On the contrary, the HDL FA composition

of poikilothermal animals (fish) had a very high content of polyunsaturated FA of

the omega3-series. A conclusion is made that composition of lipid components in

animal lipoproteins by the example of several studied species and of human has a 

non-stable character and is submitted to changes. Their most pronounced

modifications with a negative trend took place in human LDL and HDL in IHD.



Publication Types: 

    English Abstract



Mesh Terms:

    Animals

    Asthma/metabolism

    Atherosclerosis/metabolism

    Birds

    Bronchitis, Chronic/metabolism

    Cholesterol/blood*

    Fatty Acids, Unsaturated/blood*

    Fishes

    Foxes

    Humans

    Lipoproteins, HDL/blood*

    Lipoproteins, LDL/blood*

    Mink

    Myocardial Ischemia/metabolism

    Phospholipids/blood*

    Rabbits

    Rats

    Species Specificity

    Swine



Substances:

    Fatty Acids, Unsaturated

    Lipoproteins, HDL

    Lipoproteins, LDL

    Phospholipids

    Cholesterol



PMID: 17674708 [PubMed - indexed for MEDLINE]



130: Ter Arkh. 2007;79(5):9-14.



[Cardiovascular diseases in rheumatoid arthritis]



[Article in Russian]



Popkova TV, Khelkovskaia AN, Mach ES, Aleksandrova EN, Novikov AA, Novikova DS,

Nasonov EL.



AIM: To examine the significance of conventional cardiovascular factors of risk

and immunoinflammatory markers in development of vascular atherosclerosis in

rheumatoid arthritis (RA). MATERIAL AND METHODS: Conventional cardiovascular risk

factors were evaluated in 103 RA patients (85 females and 18 males, mean age 46.3

years, duration of the disease 75 months). Forty six controls (32 females and 14 

males) had no rheumatic diseases. Vascular atherosclerosis was diagnosed at

ultrasonic scanning of the carotid arteries. Highly sensitive C-reactive protein 

(hsCRP) concentration in the blood serum was measured with highly sensitive

enzyme immunoassay. RESULTS: No differences by the rate of conventional

cardiovascular risk factors between the groups were identified except arterial

hypertension. Cardiovascular complications (ischemic heart disease, myocardial

infarction, transient ischemic attacks) occurred more frequently in RA patients. 

Intima/media complex (IMC) thickness differences between the groups were not

registered. Atherosclerotic plaques were detected more often in RA patients. In

RA patients there was a correlation between IMC thickness in the carotid arteries

and age (p = 0.00001), systolic blood pressure (p = 0.001) and diastolic blood

pressure (p = 0.01), concentration of blood cholesterol (C) (p = 0.03) and total 

coronary risk (TCR) (p = 0.003). Correlation between carotid artery IMC

thickness, duration and activity of the disease, RA systemic manifestations was

not detected (p > 0.05). A mean concentration of hsCRP in RA was higher than in

the controls: 2.8 (4.4-25.6) mg/l and 1.3 (0.6-2.7) mg/ml, respectively (p =

0.001). A positive correlation existed between concentration of hsCRP and DAS4 (p

= 0.0004) and negative--with C concentration (p = 0.01), LDL C, HDL C (p = 0.02).

Increased concentration of hsCRP, IMC thickness in the carotid arteries,

existence of atherosclerotic plaques and clinical picture of vascular

atherosclerosis related insignificantly. CONCLUSION: RA patients often suffer

from cardiovascular pathology. Immunological markers of inflammation, primarily, 

hsCRP, in addition to conventional cardiovascular risk factors are essential in

development of vascular atherosclerosis.



Publication Types: 

    English Abstract



Mesh Terms:

    Adult

    Arthritis, Rheumatoid/blood

    Arthritis, Rheumatoid/complications*

    Arthritis, Rheumatoid/drug therapy

    Arthritis, Rheumatoid/immunology

    Atherosclerosis/blood

    Atherosclerosis/etiology*

    Atherosclerosis/immunology

    Atherosclerosis/ultrasonography

    C-Reactive Protein/analysis

    Cardiovascular Diseases/blood

    Cardiovascular Diseases/etiology*

    Cardiovascular Diseases/immunology

    Cardiovascular Diseases/ultrasonography

    Carotid Arteries/ultrasonography

    Cholesterol/blood

    Female

    Humans

    Male

    Middle Aged

    Predictive Value of Tests

    Risk Factors

    Triglycerides/blood



Substances:

    Triglycerides

    Cholesterol

    C-Reactive Protein



PMID: 17672067 [PubMed - indexed for MEDLINE]



131: Arkh Patol. 2007 Mar-Apr;69(2):20-3.



[Activity of prostaglandin synthetase in human arteries in atherosclerosis

(histochemical study)]



[Article in Russian]



Cherpachenko NM, Drobkova IP, Zhdanov VS.



Synthesis of prostaglandin-synthetase at the stage of development of lipid spots 

and plaques is increased and the degree of this depends on the cell response.

Increase of PgS depends on the number of cells in the intima and adventicia. Pg

synthesis in vessels is decreasing at the stage at the fibrous plaques formation.



Publication Types: 

    English Abstract



Mesh Terms:

    Adult

    Aged

    Aorta, Thoracic/enzymology*

    Aorta, Thoracic/pathology

    Atherosclerosis/enzymology*

    Atherosclerosis/pathology

    Autopsy

    Carotid Arteries/enzymology*

    Carotid Arteries/pathology

    Coronary Vessels/enzymology*

    Coronary Vessels/pathology

    Female

    Humans

    Immunohistochemistry

    Male

    Middle Aged

    Prostaglandin-Endoperoxide Synthases/metabolism*



Substances:

    Prostaglandin-Endoperoxide Synthases



PMID: 17642186 [PubMed - indexed for MEDLINE]



132: Angiol Sosud Khir. 2006;12(3):98-103.



[Methods of medical and surgical correction of atherosclerotic aorto-arterial

pathology in management of malignant neoplasms]



[Article in Russian]



Fokin AA, Vazhenin AV, Lukin AA, Tereshin OS, Korolev VN, Mironchenko MN.



South Urals Scientific Centre, Russian Academy of Medical Sciences, Urals State

Medical Academy of Advanced Medical Training, Russian Ministry of Public Health, 

Regional Oncological Dispensary, Chelyabinsk, Russia.



The article deals with 6 -year experience of the Centre of Oncoangiosurgery of

the Chelyabinsk Regional Oncological Dispensary in treatment of patients with

concomitant malignant neoplasms and atherosclerotic lesions to the aorta and

arteries. The authors analyze therapeutic outcomes in a total of 158 patients. Of

these, 81 patients were subjected to surgical correction of the blood flow. The

presence of a clinically significant atherosclerotic lesion of the aorta and

peripheral arteries in a patient should not be interpreted as an absolute or

relative contraindication to contraindication combined treatment of the tumour

concerned. In the majority of cases, atherosclerotic occlusion of femoral and

tibial arteries was treated conservatively, using <<vasaprostan>>. In

manifestation of an atherosclerotic lesion to the carotid arteries, aorta and

iliac arteries, surgical correction of the blood flow was used more often.

Usually, vascular reconstruction was carried out first. Simultaneous

interventions were performed in 16 patients; three patients died. The technique

of operations on the aorta and arteries was traditional, while for

revascularization in peripheral lesions to the arteries of the limbs more

frequently compromising methods were used (sympathectomy, profundoplasty, local

endarterectomy) on the background of prostaglandin E1 infusions.



Publication Types: 

    Case Reports

    English Abstract



Mesh Terms:

    Adult

    Aged

    Aged, 80 and over

    Aortic Aneurysm/epidemiology*

    Aortic Aneurysm/surgery

    Aortic Aneurysm/therapy*

    Atherosclerosis/epidemiology*

    Atherosclerosis/surgery

    Atherosclerosis/therapy*

    Constriction, Pathologic/epidemiology

    Constriction, Pathologic/radiography

    Constriction, Pathologic/surgery

    Female

    Femoral Artery/radiography

    Femoral Artery/surgery

    Humans

    Male

    Middle Aged

    Neoplasms/blood supply*

    Neoplasms/epidemiology*

    Vascular Surgical Procedures/methods*



PMID: 17641621 [PubMed - indexed for MEDLINE]



133: Angiol Sosud Khir. 2006;12(3):91-7.



[Twelve-year experience of bioprosthesis implantation into infrainguinal

arteries]



[Article in Russian]



Barbarash LS, Ivanov SV, Zhuravleva IIu, Anufriev AI, Kazachek IaV, Kudriavtseva 

IuA, Zinets MG.



Research Manufacturing Task Laboratory of Reconstructive Surgery of Heart and

Vessels with Clinics, Siberian Division of Russian Academy of Medical Sciences,

Kemerovo, Russia.



The study presents the results of 315 infrainguinal artery reconstructions with

bioprostheses from bovine internal mammary artery treated with 5% solution of

diepoxide (trade name "KemAngioprosthesis"). Primary patency of

KemAngioprostheses was 37.5% (n=239) in above-knee and 7.4% (n=52) in below-knee 

femoropopliteal bypasses in 8-year period, as well as 14.9% (n=24) in

femorotibial bypass in 4.5-year period. Primary patency was significantly worse

in cases of poor outflow from legs, lower limb critical ischemia, in cases of

"end-to-side" anastomosis type, as well as in patients with concomitant ischemic 

heart disease and hypertension. KemAngioprostheses demonstrated no new or unknown

complications. The most common complication was thrombosis (45.1%); infections

occurred in 4.1%, hemorrhage - in 1% and biodegradation manifested by aneurysms

and ectasia - in 1.9% cases. Indications for KemAngioprosthesis implantations

include severe, limb-threatening ischemia with unavailable autologous vein or

simultaneous two-segment arterial reconstructions in grade III-IV acute or

chronic ischemia. Besides, KemAngioprostheses can be successfully used in

above-knee femoropopliteal reconstructions.



Publication Types: 

    Clinical Trial

    English Abstract



Mesh Terms:

    Adult

    Aged

    Arteries/surgery*

    Atherosclerosis/physiopathology*

    Atherosclerosis/surgery*

    Bioprosthesis*

    Chronic Disease

    Female

    Humans

    Ischemia/surgery

    Lower Extremity/blood supply*

    Lower Extremity/surgery*

    Male

    Middle Aged



PMID: 17641620 [PubMed - indexed for MEDLINE]



134: Angiol Sosud Khir. 2006;12(3):35-9.



[Chronic bacterial-and-viral vasculitis as a possible risk factor of disordered

stability of the coronary atherosclerosis course]



[Article in Russian]



Kvantaliani TG, Pargalava NSh, Tsiklauri PA, Abzianidze TG.



Institute of Cardiology named after Academician M D Tsinamdzgvrishvili,

Scientific Research Laboratory Test House of Physicians, Centre of Angiology and 

Vascular Surgery named after N K Bokhua, Tbilisi, Georgia.



In order to assess the real significance of some plasma and vascular indices in

disorders of the stable course of coronary heart disease (CHD) in chronic

bacterial- and viral infection-invasion, we determined the blood plasma lipid

hydrogen peroxide (LHP) activity, a direct index of the lipid peroxidation

degree, and measured the concentration of specific antibodies to Chlamydia

pneumoniae (C. pneunoniae), herpes simplex virus type 1 (HSV-1), cytomegalovirus 

(CMV) and Epstein-Barr virus (EBV) by means of the enzyme-linked immunosorbent

assay (ELISA). We examined a total of 70 patients presenting with CHD combined

with a concomitant infection both with a stable course of the disease (Group One)

and acute coronary syndrome (Group Two), as well as 50 infected people without

verified signs of coronary atherosclerosis (Group Three). The comparison group

consisted of patients with CHD, being seronegative for the causative agents

referred to above. The condition of the major vessels was appropriately assessed 

by means of duplex ultrasonography (DU). Resulting from the findings of the

carried out investigation, we singled out a triad of symptoms characteristic of

the transformation of the chronic infectious process into the recurrent phase,

which for the CHD patients with the presence of the conventional risk factors of 

atherosclerosis might become a cause of the disordered stable course of the

disease and development of acute ischaemic attacks. The revealed alterations

seemed to have been based upon an infectious-origin inflammatory lesion of the

vessels, which was duly confirmed by duplex ultrasonography.



Publication Types: 

    English Abstract



Mesh Terms:

    Adult

    Aged

    Chlamydia Infections/microbiology

    Chronic Disease

    Coronary Artery Disease/microbiology*

    Coronary Artery Disease/ultrasonography

    Coronary Artery Disease/virology

    Cytomegalovirus Infections/virology

    Echocardiography, Doppler

    Enzyme-Linked Immunosorbent Assay

    Epstein-Barr Virus Infections/virology

    Female

    Herpes Simplex/virology

    Herpesvirus 1, Human/isolation & purification

    Humans

    Lipid Peroxidation/physiology

    Male

    Middle Aged

    Risk Factors

    Vasculitis/microbiology*

    Vasculitis/ultrasonography

    Vasculitis/virology



PMID: 17641612 [PubMed - indexed for MEDLINE]



135: Angiol Sosud Khir. 2006;12(3):29-32.



[Antioxidant and metabolic therapy of lower limb chronic obliterative arterial

disease]



[Article in Russian]



Koshkin VM, Murav'ev SV, Dadova LV, Kalashov PB.



Faculty Surgery Clinics, Russian State Medical University, Moscow, Russia.



Metabolic therapy is one of several therapeutic strategies that can be used in

patients with lower limb chronic obliterative arterial disease (COAD). Tanakan

(EGb76) has demonstrated high efficiency and safety in 9 controlled clinical

trials and author's clinical series in patients with lower limb COAD. Improvement

with significant increase of pain-free walking distance and beneficial safety

profile was observed in all cases. Tanakan (EGb76) is highly effective

conventional therapeutic agent for memory and attention disorders, dizziness and 

balance disturbances in adults and elderly patients. Given a common concomitance 

of these disorders and lower limb COAD, Tanakan can be recommended as a drug of

choice for treatment of chronic obliterative arteriopathy.



Publication Types: 

    English Abstract

    Review



Mesh Terms:

    Antioxidants/therapeutic use*

    Arteriosclerosis Obliterans/drug therapy*

    Arteriosclerosis Obliterans/physiopathology*

    Atherosclerosis

    Chronic Disease

    Humans

    Lower Extremity/blood supply*

    Plant Extracts/therapeutic use

    Vasodilator Agents/therapeutic use



Substances:

    Antioxidants

    Ginkgo biloba extract 761

    Plant Extracts

    Vasodilator Agents



PMID: 17641611 [PubMed - indexed for MEDLINE]



136: Vestn Rentgenol Radiol. 2006 Jul-Aug;(4):24-8.



[Color duplex scanning in the evaluation of endovascular interventions into

autovenous shunts]



[Article in Russian]



Maliutina ED.



The paper describes a role of color duplex scanning (CDS) in the assessment of

results of endovascular interventions into autovenous shunts, including in situ

ones. From 2000 to 2005, the unit of vascular surgery of Clinical Hospital No. 83

performed 148 femoropopliteal and femototibial repairs, including the in situ

technique, in 138 patients with atherosclerosis obliterans and stenotic and

occlusive changes in the femoropopliteal segment and shin arteries. CDS

monitoring revealed 42 shunts with hemodynamically significant changes, which was

an indication for preventive endovascular operations --balloon angioplasty (BAG) 

and in one case for autovenous shunt stenting. According to CDS data, an adequate

endovascular intervention with restoration of the geometry of shunts or their

anastomoses was performed in 40 (95.2%) cases, by recording the great

bloodstream; there were hemodynamically significant complications (residual

stenoses) in 2 (4.8%) cases and hemodynamically insignificant ones in 5 (12%). In

the late period, hemodynamically significant complications (thromboses and

restenoses of an angioplasty site) and insignificant restenoses were detected in 

14 (33%) and 5 (12%) cases, respectively. After endovascular intervention,

supplemented shunt patency was 40.89 +/- 18.5% with the average follow-up length 

of 23.3 +/- 2.3 months. Based on the complications detected at a hospital stage

and in the late follow-up period after preventive primary endovascular

intervention, 10 endovascular reinterventions were performed, which increased

patency time in the group of endovascular reinterventions into the shunts by 19.6

+/- 3.8 months. Thus, the developed echosemiotics of shunts, including an in-situ

autovenous shunt permits evaluation of the state of a shunt and the hemodynamic

significance of the found changes in due time and early at surgery. CDS

monitoring makes it possible to specify indications for preventive operations, to

choose a repeated reparative procedure in a patient with thromboses of

femoropopliteal and femorotibial segments.



Publication Types: 

    English Abstract



Mesh Terms:

    Arterial Occlusive Diseases*/physiopathology

    Arterial Occlusive Diseases*/surgery

    Arterial Occlusive Diseases*/ultrasonography

    Arteriovenous Shunt, Surgical/methods

    Blood Flow Velocity/physiology

    Female

    Femoral Artery*

    Follow-Up Studies

    Humans

    Male

    Middle Aged

    Popliteal Artery*

    Reproducibility of Results

    Retrospective Studies

    Saphenous Vein/transplantation*

    Tibial Arteries*

    Treatment Outcome

    Ultrasonography, Doppler, Color*



PMID: 17639614 [PubMed - indexed for MEDLINE]



137: Ter Arkh. 2007;79(4):10-4.



[Myocardial contractility evaluation by radionuclide 4D-tomoventriculography in

patients with ischemic heart disease]



[Article in Russian]



Belenkov IuN, Sergienko VB, Bugriä­ ME.



AIM: To estimate the capabilities of the new technique radionuclide

4D-tomoventriculography (4D-RTVG) versus conventional methods, such as

radionuclide equilibrium ventriculography (REVG), ECG-synchronized single photon 

emission computerized tomography (SPECT), and echocardiography (EchoCG), in the

evaluation of systolic and diastolic dysfunction in patients with coronary heart 

disease (CHD). MATERIALS AND METHODS: The study included 29 patients (19 males

and 10 females) aged 43 to 66 years who had CHD. The diagnosis of CHD was

established on the basis of coronary angiographic findings when the signs of

coronary atherosclerosis were found. All the patients underwent 4D-RTVG, REVG,

myocardial ECG-synchronized SPECT, and Echo CG. RESULTS: There was a strong

correlation of the values obtained by 4D-RTVG versus REVG and EchoCG when

ejection fraction and left ventricular (LV) end-diastolic volume and the indices 

reflecting LV blood filling and ejection velocity were estimated. The correlation

between the values provided by 4D-RTVG and myocardial ECG-synchronized SPECT

females was slightly weaker. CONCLUSION: The findings suggest that 4D-RTVG is

highly reliable in evaluating both LV systolic and diastolic functions. That fact

the technique is easy-to-use and mini-invasive shows that it may be clinically

applied.



Publication Types: 

    Comparative Study

    English Abstract



Mesh Terms:

    Adult

    Aged

    Diastole

    Echocardiography

    Electrocardiography

    Female

    Heart/physiopathology

    Heart/radionuclide imaging*

    Humans

    Male

    Middle Aged

    Myocardial Contraction/physiology*

    Myocardial Ischemia/physiopathology

    Myocardial Ischemia/radionuclide imaging*

    Radionuclide Ventriculography

    Sensitivity and Specificity

    Systole

    Technetium Tc 99m Sestamibi/diagnostic use

    Tomography, Emission-Computed, Single-Photon

    Ventricular Function, Left/physiology



Substances:

    Technetium Tc 99m Sestamibi



PMID: 17564011 [PubMed - indexed for MEDLINE]



138: Zh Vopr Neirokhir Im N N Burdenko. 2007 Jan-Mar;(1):36-9; discussion 39.



[Venous thromboembolic events in neurosurgical patients. Part I. Analysis of

their incidence on the basis of autopsy material]



[Article in Russian]



Markina MS, Lubnin AIu, Korshunov AG, Kozlov AV.



Mesh Terms:

    Adult

    Age Factors

    Atherosclerosis/complications

    Atherosclerosis/epidemiology

    Autopsy

    Female

    Humans

    Incidence

    Male

    Middle Aged

    Moscow/epidemiology

    Neurosurgical Procedures/adverse effects

    Neurosurgical Procedures/mortality

    Neurosurgical Procedures/statistics & numerical data*

    Postoperative Complications/epidemiology

    Postoperative Complications/etiology

    Postoperative Complications/mortality

    Pulmonary Artery/pathology

    Thromboembolism/epidemiology*

    Thromboembolism/etiology

    Thromboembolism/mortality

    Venous Thrombosis/diagnosis

    Venous Thrombosis/epidemiology*

    Venous Thrombosis/mortality



PMID: 17526251 [PubMed - indexed for MEDLINE]



139: Patol Fiziol Eksp Ter. 2007 Jan-Mar;(1):18-21.



[Role of lysosomal enzymes in the genesis of major clinical and

pathophysiological syndromes: facts and hypotheses]



[Article in Russian]



Efremov AV, Ruiatkina LA, Tsygankova OV, Bondareva ZG.



Publication Types: 

    Review



Mesh Terms:

    Animals

    Apoptosis

    Atherosclerosis/enzymology

    Atherosclerosis/etiology

    Cardiovascular Diseases/enzymology*

    Cardiovascular Diseases/etiology

    Enzymes/physiology*

    Humans

    Lysosomes/enzymology*

    Lysosomes/pathology



Substances:

    Enzymes



PMID: 17526212 [PubMed - indexed for MEDLINE]



140: Ter Arkh. 2007;79(3):84-92.



[Systemic vasculitis and atherosclerosis]



[Article in Russian]



Shilkina NP, Driazhenkova IV.



Publication Types: 

    Review



Mesh Terms:

    Atherosclerosis*/diagnosis

    Atherosclerosis*/etiology

    Atherosclerosis*/immunology

    Diagnosis, Differential

    Humans

    Vasculitis*/diagnosis

    Vasculitis*/etiology

    Vasculitis*/immunology



PMID: 17526204 [PubMed - indexed for MEDLINE]