In order to measure the density of the Universe, it is necessary to sample a region that is larger than the scale on which the Universe becomes approximately homogeneous. ... When applied to clusters of galaxies we find a mass to luminosity ratio that implies a density of the Universe that is about 0.3 times the critical density. ... Thus the mass-to-muinosity ratio appears to vary with the size of the region measured, from 3 in the solar neighborhood to 30 in galaxies to 300 in clusters of galaxies. ...