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. 1

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2.
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. 3

, , . , (s) ( ) s k(s) (s) . . (s) =(x(s),y(s), z ( s )) , .. x(s) , y(s) z ( s ) , '(s) =(x'(s),y'(s), z '( s )) 1. v(s) = '(s) ( 1), k ( s )=| ''( s )| , n ( s ) = ''( s )/| ''( s )| ( , , .. ), b(s) = [v(s),n(s)] ( ). , b'(s) n(s) . (s) , , (s) . , b'(x)= - (s)n(s) . . . f(s) g (s) (s) k(s) , f(s) , (s) , g(s) . . . ( ):

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· k(s) = 0 , (s) . ; · (s) = 0 , (s) ; · k(s) = const > 0 , . (s) = 0; · k ( s ) = const > 0 ( s ) = const 0 , ( s ) , . . 4.

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, . k ( s ) = a cos 2(s)+1.

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. 6.

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. 8

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. 11 HUMAN PRION PROTEIN (, )

, , .

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, (-), , . , , , . , , . , , , , , , . , , , . , , O(n 2 ) , n .

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(, ). . . , (, ) -. , . . ( ). ( ). . , , , . , .. .

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, , , . ( 07-01-00648, 0501-22002 ), ( -660.2008.1), , 2.1.1.7988.

1. .., ..-, .., , , , 4 (1970), . 94107. 2. Fold fully forecast. Computer predicts protein's shape from sequence alone. Nature News ( 23 Sep 2002 ), doi: 10.1038/news020923-4, News http://www.nature.com/news/2002/020923/full/news020923-4.html

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3. ... . http://www.moldyn.org/library/moldyn/moldyn.htm 4. .., .., , 1999, http://www.moldyn.ru/library/md/default.htm 5. ... . 1999-2000. 6. .., .. `` '', , `` ``'''', 2002.

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