| 
        
            Domain
        
         | 
        
            Instances
        
         | 
        
            PDB entries
        
         | 
        
            DNA/RNA bond instances
        
         | 
        
        
            
                2OG-FeII_Oxy (2OG-Fe(II) oxygenase superfamily) 
  | 
                12 | 12 | 
                12 | 
            
        
            
                3_5_exonuc (3'-5' exonuclease) 
  | 
                12 | 12 | 
                12 | 
            
        
            
                5_3_exonuc (5'-3' exonuclease, C-terminal SAM fold) 
  | 
                1 | 1 | 
                0 | 
            
        
            
                5_3_exonuc_N (5'-3' exonuclease, N-terminal resolvase-like domain) 
  | 
                3 | 2 | 
                1 | 
            
        
            
                7kD_DNA_binding (7kD DNA-binding domain) 
  | 
                22 | 19 | 
                21 | 
            
        
            
                AAA (ATPase family associated with various cellular activities (AAA)) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                Aconitase (Aconitase family (aconitate hydratase)) 
  | 
                4 | 1 | 
                3 | 
            
        
            
                Aconitase_C (Aconitase C-terminal domain) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                Ada_Zn_binding (Metal binding domain of Ada) 
  | 
                2 | 2 | 
                2 | 
            
        
            
                Adenine_glyco (Methyladenine glycosylase) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                AHSA1 (Activator of Hsp90 ATPase homolog 1-like protein) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                AlkA_N (AlkA N-terminal domain) 
  | 
                34 | 9 | 
                0 | 
            
        
            
                Ank (Ankyrin repeat) 
  | 
                13 | 3 | 
                0 | 
            
        
            
                Anticodon_1 (Anticodon-binding domain) 
  | 
                15 | 9 | 
                15 | 
            
        
            
                AP2 (AP2 domain) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                AP_endonuc_2 (Xylose isomerase-like TIM barrel) 
  | 
                4 | 3 | 
                3 | 
            
        
            
                AraC_E_bind (Bacterial transcription activator, effector binding domain) 
  | 
                4 | 1 | 
                0 | 
            
        
            
                Arc (Arc-like DNA binding domain) 
  | 
                12 | 3 | 
                12 | 
            
        
            
                Arch_ATPase (Archaeal ATPase) 
  | 
                36 | 4 | 
                0 | 
            
        
            
                Arg_repressor (Arginine repressor, DNA binding domain) 
  | 
                5 | 2 | 
                5 | 
            
        
            
                Arg_repressor_C (Arginine repressor, C-terminal domain) 
  | 
                1 | 1 | 
                0 | 
            
        
            
                Arg_tRNA_synt_N (Arginyl tRNA synthetase N terminal domain) 
  | 
                2 | 2 | 
                2 | 
            
        
            
                ARID (ARID/BRIGHT DNA binding domain) 
  | 
                2 | 2 | 
                2 | 
            
        
            
                AsnC_trans_reg (AsnC family) 
  | 
                1 | 1 | 
                0 | 
            
        
            
                Asparaginase (Asparaginase) 
  | 
                2 | 1 | 
                0 | 
            
        
            
                ATP-synt_ab (ATP synthase alpha/beta family, nucleotide-binding domain) 
  | 
                32 | 6 | 
                2 | 
            
        
            
                Autoind_bind (Autoinducer binding domain) 
  | 
                8 | 2 | 
                0 | 
            
        
            
                B3_4 (B3/4 domain) 
  | 
                2 | 2 | 
                1 | 
            
        
            
                B5 (tRNA synthetase B5 domain) 
  | 
                2 | 2 | 
                0 | 
            
        
            
                Bac_DnaA_C (Bacterial  dnaA  protein helix-turn-helix domain) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                Bac_DNA_binding (Bacterial DNA-binding protein) 
  | 
                26 | 11 | 
                26 | 
            
        
            
                BAF (Barrier to autointegration factor) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                BamHI (Restriction endonuclease BamHI) 
  | 
                8 | 4 | 
                7 | 
            
        
            
                Beta-trefoil (Beta-trefoil) 
  | 
                6 | 6 | 
                6 | 
            
        
            
                BHD_1 (Rad4 beta-hairpin domain 1) 
  | 
                2 | 2 | 
                2 | 
            
        
            
                BHD_2 (Rad4 beta-hairpin domain 2) 
  | 
                2 | 2 | 
                2 | 
            
        
            
                BHD_3 (Rad4 beta-hairpin domain 3) 
  | 
                2 | 2 | 
                2 | 
            
        
            
                BRCA-2_helical (BRCA2, helical) 
  | 
                1 | 1 | 
                0 | 
            
        
            
                BRCA-2_OB1 (BRCA2, oligonucleotide/oligosaccharide-binding, domain 1) 
  | 
                1 | 1 | 
                0 | 
            
        
            
                BRCA-2_OB3 (BRCA2, oligonucleotide/oligosaccharide-binding, domain 3) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                BRF1 (Brf1-like TBP-binding domain) 
  | 
                4 | 1 | 
                0 | 
            
        
            
                BrkDBD (Brinker DNA-binding domain) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                Bromo_coat (Bromovirus coat protein) 
  | 
                3 | 1 | 
                3 | 
            
        
            
                Bse634I (Cfr10I/Bse634I restriction endonuclease) 
  | 
                8 | 3 | 
                8 | 
            
        
            
                Btz (CASC3/Barentsz eIF4AIII binding) 
  | 
                14 | 4 | 
                0 | 
            
        
            
                bZIP_1 (bZIP transcription factor) 
  | 
                49 | 23 | 
                48 | 
            
        
            
                bZIP_2 (Basic region leucine zipper) 
  | 
                44 | 21 | 
                43 | 
            
        
            
                C1-set (Immunoglobulin C1-set domain) 
  | 
                36 | 15 | 
                0 | 
            
        
            
                CAF1 (CAF1 family ribonuclease) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                CAT_RBD (CAT RNA binding domain) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                CBFD_NFYB_HMF (Histone-like transcription factor (CBF/NF-Y) and archaeal histone) 
  | 
                6 | 3 | 
                6 | 
            
        
            
                CBF_beta (Core binding factor beta subunit) 
  | 
                3 | 2 | 
                0 | 
            
        
            
                CcdA (Post-segregation antitoxin CcdA) 
  | 
                4 | 2 | 
                4 | 
            
        
            
                CDC13-DNA-bind (CDC13, ssDNA binding) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                Cdc6_C (CDC6, C terminal) 
  | 
                3 | 2 | 
                3 | 
            
        
            
                CENP-B_N (CENP-B N-terminal DNA-binding domain) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                CenpB-DNA-bind (Centromere binding protein B, DNA binding) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                CHORD (CHORD) 
  | 
                4 | 1 | 
                3 | 
            
        
            
                cNMP_binding (Cyclic nucleotide-binding domain) 
  | 
                24 | 15 | 
                7 | 
            
        
            
                Como_LCP (Large coat protein) 
  | 
                2 | 2 | 
                1 | 
            
        
            
                Como_SCP (Small coat protein) 
  | 
                2 | 2 | 
                0 | 
            
        
            
                CPSF_A (CPSF A subunit region) 
  | 
                2 | 2 | 
                0 | 
            
        
            
                Cro (Cro) 
  | 
                8 | 3 | 
                6 | 
            
        
            
                Crp (Bacterial regulatory proteins, crp family) 
  | 
                23 | 14 | 
                23 | 
            
        
            
                CSD ('Cold-shock' DNA-binding domain) 
  | 
                3 | 2 | 
                3 | 
            
        
            
                CsrA (Global regulator protein family) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                Cucumo_2B (Cucumovirus protein 2B) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                Cucumo_coat (Cucumovirus coat protein) 
  | 
                3 | 1 | 
                1 | 
            
        
            
                CUT (CUT domain) 
  | 
                4 | 3 | 
                4 | 
            
        
            
                Cyclin_N (Cyclin, N-terminal domain) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                DALR_1 (DALR anticodon binding domain) 
  | 
                2 | 2 | 
                2 | 
            
        
            
                DALR_2 (DALR domain) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                dCMP_cyt_deam_1 (Cytidine and deoxycytidylate deaminase zinc-binding region) 
  | 
                4 | 1 | 
                4 | 
            
        
            
                DEAD (DEAD/DEAH box helicase) 
  | 
                13 | 7 | 
                12 | 
            
        
            
                DHO_dh (Dihydroorotate dehydrogenase) 
  | 
                36 | 4 | 
                0 | 
            
        
            
                DKCLD (DKCLD (NUC011) domain) 
  | 
                2 | 2 | 
                2 | 
            
        
            
                DnaB (DnaB-like helicase N terminal domain) 
  | 
                2 | 1 | 
                1 | 
            
        
            
                DnaB_bind (DnaB-helicase binding domain of primase) 
  | 
                2 | 1 | 
                0 | 
            
        
            
                DnaB_C (DnaB-like helicase C terminal domain) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                DNA_binding_1 (6-O-methylguanine DNA methyltransferase, DNA binding domain) 
  | 
                6 | 3 | 
                5 | 
            
        
            
                DNA_ligase_aden (NAD-dependent DNA ligase adenylation domain) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                DNA_ligase_A_C (ATP dependent DNA ligase C terminal region) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                DNA_ligase_A_M (ATP dependent DNA ligase domain) 
  | 
                6 | 3 | 
                6 | 
            
        
            
                DNA_ligase_A_N (DNA ligase N terminus) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                DNA_ligase_OB (NAD-dependent DNA ligase OB-fold domain) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                DNA_ligase_ZBD (NAD-dependent DNA ligase C4 zinc finger domain) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                DNA_methylase (C-5 cytosine-specific DNA methylase) 
  | 
                27 | 26 | 
                27 | 
            
        
            
                DNA_photolyase (DNA photolyase) 
  | 
                6 | 3 | 
                6 | 
            
        
            
                DNA_pol3_alpha (Bacterial DNA polymerase III alpha subunit) 
  | 
                7 | 4 | 
                5 | 
            
        
            
                DNA_pol3_beta (DNA polymerase III beta subunit, N-terminal domain) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                DNA_pol3_beta_2 (DNA polymerase III beta subunit, central domain) 
  | 
                2 | 1 | 
                1 | 
            
        
            
                DNA_pol3_beta_3 (DNA polymerase III beta subunit, C-terminal domain) 
  | 
                2 | 1 | 
                0 | 
            
        
            
                DNA_pol_A (DNA polymerase family A) 
  | 
                84 | 77 | 
                78 | 
            
        
            
                DNA_pol_B (DNA polymerase family B) 
  | 
                45 | 13 | 
                38 | 
            
        
            
                DNA_pol_B_2 (DNA polymerase type B, organellar and viral) 
  | 
                15 | 6 | 
                14 | 
            
        
            
                DNA_pol_B_exo (DNA polymerase family B, exonuclease domain) 
  | 
                64 | 14 | 
                28 | 
            
        
            
                DNA_pol_lambd_f (Fingers domain of DNA polymerase lambda) 
  | 
                143 | 128 | 
                143 | 
            
        
            
                DNA_primase_S (Eukaryotic and archaeal DNA primase small subunit) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                DNA_RNApol_7kD (DNA directed RNA polymerase, 7 kDa subunit) 
  | 
                25 | 24 | 
                0 | 
            
        
            
                DNA_topoisoIV (DNA gyrase/topoisomerase IV, subunit A) 
  | 
                2 | 1 | 
                1 | 
            
        
            
                dsrm (Double-stranded RNA binding motif) 
  | 
                23 | 12 | 
                17 | 
            
        
            
                DSS1_SEM1 (DSS1/SEM1 family) 
  | 
                2 | 1 | 
                0 | 
            
        
            
                DUF1610 (Domain of unknown function (DUF1610)) 
  | 
                16 | 2 | 
                11 | 
            
        
            
                E2F_TDP (E2F/DP family winged-helix DNA-binding domain) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                EBV-NA1 (Epstein Barr virus nuclear antigen-1, DNA-binding domain) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                EcoRI (Restriction endonuclease EcoRI) 
  | 
                7 | 7 | 
                7 | 
            
        
            
                EcoRII-C (EcoRII C terminal) 
  | 
                10 | 3 | 
                10 | 
            
        
            
                EFG_C (Elongation factor G C-terminus) 
  | 
                5 | 5 | 
                2 | 
            
        
            
                EFG_IV (Elongation factor G, domain IV) 
  | 
                5 | 4 | 
                1 | 
            
        
            
                eIF-1a (Translation initiation factor 1A / IF-1) 
  | 
                2 | 2 | 
                1 | 
            
        
            
                EndIII_4Fe-2S (Iron-sulfur binding domain of endonuclease III) 
  | 
                6 | 6 | 
                0 | 
            
        
            
                Endonuc-BglII (Restriction endonuclease BglII) 
  | 
                8 | 4 | 
                8 | 
            
        
            
                Endonuc-BsobI (Restriction endonuclease BsobI) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                Endonuc-dimeris (T4 recombination endonuclease VII, dimerisation) 
  | 
                4 | 2 | 
                4 | 
            
        
            
                Endonuc-EcoRV (Restriction endonuclease EcoRV) 
  | 
                55 | 27 | 
                55 | 
            
        
            
                Endonuc-FokI_C (Restriction endonuclease FokI, C terminal) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                Endonuc-HincII (Restriction endonuclease HincII) 
  | 
                52 | 18 | 
                48 | 
            
        
            
                Endonuc-MspI (Restriction endonuclease MspI) 
  | 
                4 | 2 | 
                4 | 
            
        
            
                Endonuc-PvuII (Restriction endonuclease PvuII) 
  | 
                10 | 5 | 
                10 | 
            
        
            
                Endonuclease_1 (Endonuclease I) 
  | 
                6 | 2 | 
                6 | 
            
        
            
                Endonuclease_5 (Endonuclease V) 
  | 
                4 | 2 | 
                4 | 
            
        
            
                Endonuclease_7 (Recombination endonuclease VII) 
  | 
                4 | 2 | 
                4 | 
            
        
            
                ERCC4 (ERCC4 domain) 
  | 
                2 | 1 | 
                1 | 
            
        
            
                Ets (Ets-domain) 
  | 
                22 | 15 | 
                22 | 
            
        
            
                Exc (Excisionase-like protein) 
  | 
                7 | 3 | 
                6 | 
            
        
            
                Exonuc_V_gamma (Exodeoxyribonuclease V, gamma subunit) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                Exonuc_X-T (Exonuclease) 
  | 
                4 | 1 | 
                2 | 
            
        
            
                Exo_endo_phos (Endonuclease/Exonuclease/phosphatase family) 
  | 
                10 | 6 | 
                10 | 
            
        
            
                FadR_C (FadR C-terminal domain) 
  | 
                4 | 2 | 
                0 | 
            
        
            
                FAD_binding_7 (FAD binding domain of DNA photolyase) 
  | 
                6 | 3 | 
                6 | 
            
        
            
                Fapy_DNA_glyco (Formamidopyrimidine-DNA glycosylase N-terminal domain) 
  | 
                31 | 26 | 
                31 | 
            
        
            
                FCD (FCD domain) 
  | 
                4 | 2 | 
                0 | 
            
        
            
                FDX-ACB (Ferredoxin-fold anticodon binding domain) 
  | 
                2 | 2 | 
                2 | 
            
        
            
                FeoA (FeoA domain) 
  | 
                9 | 2 | 
                0 | 
            
        
            
                Fe_dep_repress (Iron dependent repressor, N-terminal DNA binding domain) 
  | 
                28 | 6 | 
                28 | 
            
        
            
                Fe_dep_repr_C (Iron dependent repressor, metal binding and dimerisation domain) 
  | 
                28 | 6 | 
                0 | 
            
        
            
                Flavi_DEAD (Flavivirus DEAD domain) 
  | 
                12 | 6 | 
                12 | 
            
        
            
                FLO_LFY (Floricaula / Leafy protein) 
  | 
                2 | 2 | 
                2 | 
            
        
            
                Flp_C (Recombinase Flp protein) 
  | 
                12 | 3 | 
                12 | 
            
        
            
                Flp_N (Recombinase Flp protein N-terminus) 
  | 
                12 | 3 | 
                12 | 
            
        
            
                Flu_NS1 (Influenza non-structural protein (NS1)) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                FokI_C (Restriction endonuclease FokI, catalytic domain) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                FokI_N (Restriction endonuclease FokI, recognition domain) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                Fork_head (Fork head domain) 
  | 
                19 | 9 | 
                19 | 
            
        
            
                Formyl_trans_C (Formyl transferase, C-terminal domain) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                Formyl_trans_N (Formyl transferase) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                Ftsk_gamma (Ftsk gamma domain) 
  | 
                6 | 1 | 
                6 | 
            
        
            
                GAD (GAD domain) 
  | 
                7 | 4 | 
                1 | 
            
        
            
                GAGA (GAGA factor) 
  | 
                2 | 2 | 
                2 | 
            
        
            
                Gal4_dimer (Gal4-like dimerisation domain) 
  | 
                4 | 2 | 
                4 | 
            
        
            
                GATA (GATA zinc finger) 
  | 
                13 | 11 | 
                13 | 
            
        
            
                GatB (PET112 family, C terminal region) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                GatB_N (PET112 family, N terminal region) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                GatB_Yqey (GatB domain) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                GCM (GCM motif protein) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                GerE (Bacterial regulatory proteins, luxR family) 
  | 
                22 | 6 | 
                22 | 
            
        
            
                GntR (Bacterial regulatory proteins, gntR family) 
  | 
                4 | 2 | 
                4 | 
            
        
            
                GTP_EFTU (Elongation factor Tu GTP binding domain) 
  | 
                23 | 16 | 
                12 | 
            
        
            
                GTP_EFTU_D2 (Elongation factor Tu domain 2) 
  | 
                30 | 16 | 
                18 | 
            
        
            
                GTP_EFTU_D3 (Elongation factor Tu C-terminal domain) 
  | 
                14 | 10 | 
                9 | 
            
        
            
                H2TH (Formamidopyrimidine-DNA glycosylase H2TH domain) 
  | 
                31 | 26 | 
                31 | 
            
        
            
                Helicase_C (Helicase conserved C-terminal domain) 
  | 
                20 | 11 | 
                14 | 
            
        
            
                HGTP_anticodon (Anticodon binding domain) 
  | 
                13 | 4 | 
                11 | 
            
        
            
                HHH (Helix-hairpin-helix motif) 
  | 
                49 | 26 | 
                39 | 
            
        
            
                HhH-GPD (HhH-GPD superfamily base excision DNA repair protein) 
  | 
                63 | 38 | 
                63 | 
            
        
            
                HipA_C (HipA-like C-terminal domain) 
  | 
                2 | 2 | 
                0 | 
            
        
            
                HipA_N (HipA-like N-terminal domain) 
  | 
                2 | 2 | 
                0 | 
            
        
            
                Histone (Core histone H2A/H2B/H3/H4) 
  | 
                280 | 35 | 
                280 | 
            
        
            
                HLH (Helix-loop-helix DNA-binding domain) 
  | 
                29 | 9 | 
                27 | 
            
        
            
                HMG_box (HMG (high mobility group) box) 
  | 
                14 | 12 | 
                14 | 
            
        
            
                HNF-1_N (Hepatocyte nuclear factor 1 (HNF-1), N terminus) 
  | 
                4 | 2 | 
                4 | 
            
        
            
                HNH (HNH endonuclease) 
  | 
                5 | 3 | 
                5 | 
            
        
            
                Homeobox (Homeobox domain) 
  | 
                63 | 36 | 
                63 | 
            
        
            
                Hom_end (Homing endonuclease) 
  | 
                4 | 2 | 
                3 | 
            
        
            
                Hom_end_hint (Hom_end-associated Hint) 
  | 
                2 | 2 | 
                2 | 
            
        
            
                Hormone_recep (Ligand-binding domain of nuclear hormone receptor) 
  | 
                6 | 3 | 
                0 | 
            
        
            
                HSF_DNA-bind (HSF-type DNA-binding) 
  | 
                5 | 3 | 
                3 | 
            
        
            
                HTH_3 (Helix-turn-helix) 
  | 
                24 | 12 | 
                24 | 
            
        
            
                HTH_5 (Bacterial regulatory protein, arsR family) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                HTH_7 (Helix-turn-helix domain of resolvase) 
  | 
                22 | 13 | 
                22 | 
            
        
            
                HTH_AraC (Bacterial regulatory helix-turn-helix proteins, AraC family) 
  | 
                14 | 5 | 
                14 | 
            
        
            
                HutP (HutP) 
  | 
                9 | 4 | 
                9 | 
            
        
            
                IBD (Transcription-initiator DNA-binding domain IBD) 
  | 
                7 | 2 | 
                5 | 
            
        
            
                IF3_C (Translation initiation factor IF-3, C-terminal domain) 
  | 
                1 | 1 | 
                0 | 
            
        
            
                ig (Immunoglobulin domain) 
  | 
                36 | 15 | 
                7 | 
            
        
            
                IgG_binding_B (B domain) 
  | 
                1 | 1 | 
                0 | 
            
        
            
                IMS (impB/mucB/samB family) 
  | 
                96 | 72 | 
                96 | 
            
        
            
                Integrase_DNA (DNA binding domain of tn916 integrase) 
  | 
                2 | 2 | 
                2 | 
            
        
            
                IPPT (IPP transferase) 
  | 
                10 | 5 | 
                10 | 
            
        
            
                IRF (Interferon regulatory factor transcription factor) 
  | 
                20 | 6 | 
                20 | 
            
        
            
                KH_1 (KH domain) 
  | 
                32 | 13 | 
                25 | 
            
        
            
                KH_2 (KH domain) 
  | 
                131 | 98 | 
                1 | 
            
        
            
                KorB (KorB domain) 
  | 
                4 | 1 | 
                4 | 
            
        
            
                KOW (KOW motif) 
  | 
                129 | 129 | 
                112 | 
            
        
            
                Ku (Ku70/Ku80 beta-barrel domain) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                Ku_C (Ku70/Ku80 C-terminal arm) 
  | 
                2 | 1 | 
                1 | 
            
        
            
                Ku_N (Ku70/Ku80 N-terminal alpha/beta domain) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                L15 (Ribosomal protein L15) 
  | 
                185 | 127 | 
                169 | 
            
        
            
                La (La domain) 
  | 
                11 | 6 | 
                11 | 
            
        
            
                LacI (Bacterial regulatory proteins, lacI family) 
  | 
                50 | 34 | 
                47 | 
            
        
            
                Lactamase_B (Metallo-beta-lactamase superfamily) 
  | 
                6 | 2 | 
                6 | 
            
        
            
                LAG1-DNAbind (LAG1, DNA binding) 
  | 
                6 | 6 | 
                6 | 
            
        
            
                LAGLIDADG_1 (LAGLIDADG endonuclease) 
  | 
                58 | 23 | 
                58 | 
            
        
            
                LAGLIDADG_2 (LAGLIDADG DNA endonuclease family) 
  | 
                4 | 3 | 
                4 | 
            
        
            
                LepA_C (GTP-binding protein LepA C-terminus) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                Levi_coat (Levivirus coat protein) 
  | 
                84 | 28 | 
                83 | 
            
        
            
                LRR_1 (Leucine Rich Repeat) 
  | 
                42 | 1 | 
                12 | 
            
        
            
                LRR_3 (Leucine Rich Repeat) 
  | 
                10 | 1 | 
                4 | 
            
        
            
                LSM (LSM domain) 
  | 
                34 | 3 | 
                27 | 
            
        
            
                LytTR (LytTr DNA-binding domain) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                Mago_nashi (Mago nashi protein) 
  | 
                7 | 4 | 
                0 | 
            
        
            
                MamL-1 (MamL-1 domain) 
  | 
                1 | 1 | 
                0 | 
            
        
            
                MarR (MarR family) 
  | 
                6 | 1 | 
                6 | 
            
        
            
                MBD (Methyl-CpG binding domain) 
  | 
                2 | 2 | 
                2 | 
            
        
            
                MEF2_binding (MEF2 binding) 
  | 
                1 | 1 | 
                0 | 
            
        
            
                MerR (MerR family regulatory protein) 
  | 
                10 | 9 | 
                10 | 
            
        
            
                MerR-DNA-bind (MerR, DNA binding) 
  | 
                3 | 2 | 
                3 | 
            
        
            
                Metallophos (Calcineurin-like phosphoesterase) 
  | 
                3 | 2 | 
                3 | 
            
        
            
                MethyltransfD12 (D12 class N6 adenine-specific DNA methyltransferase) 
  | 
                16 | 5 | 
                14 | 
            
        
            
                Methyltransf_11 (Methyltransferase domain) 
  | 
                36 | 11 | 
                1 | 
            
        
            
                Methyltransf_1N (6-O-methylguanine DNA methyltransferase, ribonuclease-like domain) 
  | 
                10 | 3 | 
                0 | 
            
        
            
                MetJ (Met Apo-repressor, MetJ) 
  | 
                22 | 6 | 
                22 | 
            
        
            
                MH1 (MH1 domain) 
  | 
                4 | 2 | 
                4 | 
            
        
            
                Microvir_J (Microvirus J protein) 
  | 
                3 | 3 | 
                3 | 
            
        
            
                MMR_HSR1 (GTPase of unknown function) 
  | 
                8 | 8 | 
                1 | 
            
        
            
                MMtag (Kinase phosphorylation protein) 
  | 
                5 | 1 | 
                0 | 
            
        
            
                MobB (Molybdopterin guanine dinucleotide synthesis protein B) 
  | 
                42 | 6 | 
                1 | 
            
        
            
                MRP (Mitochondrial RNA binding protein MRP) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                MutH (DNA mismatch repair enzyme MutH) 
  | 
                3 | 2 | 
                3 | 
            
        
            
                MutS_I (MutS domain I) 
  | 
                45 | 18 | 
                29 | 
            
        
            
                MutS_II (MutS domain II) 
  | 
                42 | 18 | 
                0 | 
            
        
            
                MutS_III (MutS domain III) 
  | 
                36 | 18 | 
                31 | 
            
        
            
                MutS_IV (MutS family domain IV) 
  | 
                36 | 18 | 
                36 | 
            
        
            
                MutS_V (MutS domain V) 
  | 
                38 | 18 | 
                0 | 
            
        
            
                Mu_DNA_bind (Mu DNA-binding domain) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                Myb_DNA-binding (Myb-like DNA-binding domain) 
  | 
                20 | 10 | 
                18 | 
            
        
            
                Myc-LZ (Myc leucine zipper domain) 
  | 
                2 | 1 | 
                0 | 
            
        
            
                NAD_synthase (NAD synthase) 
  | 
                10 | 3 | 
                0 | 
            
        
            
                NaeI (Restriction endonuclease NaeI) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                NDT80_PhoG (NDT80 / PhoG like DNA-binding  family) 
  | 
                11 | 11 | 
                11 | 
            
        
            
                NgoMIV_restric (NgoMIV restriction enzyme) 
  | 
                4 | 1 | 
                4 | 
            
        
            
                NID (Nmi/IFP 35 domain (NID)) 
  | 
                11 | 11 | 
                0 | 
            
        
            
                NikR_C (NikR C terminal nickel binding domain) 
  | 
                8 | 1 | 
                4 | 
            
        
            
                Nop (Putative snoRNA binding domain) 
  | 
                3 | 1 | 
                3 | 
            
        
            
                Nop10p (Nucleolar RNA-binding protein, Nop10p family) 
  | 
                2 | 2 | 
                1 | 
            
        
            
                NOSIC (NOSIC (NUC001) domain) 
  | 
                2 | 1 | 
                0 | 
            
        
            
                NTP_transf_2 (Nucleotidyltransferase domain) 
  | 
                29 | 22 | 
                26 | 
            
        
            
                NUMOD4 (NUMOD4 motif) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                OB_RNB (Ribonuclease B OB domain) 
  | 
                1 | 1 | 
                0 | 
            
        
            
                OGG_N (8-oxoguanine DNA glycosylase, N-terminal domain) 
  | 
                23 | 23 | 
                0 | 
            
        
            
                Omega_Repress (Omega Transcriptional Repressor) 
  | 
                12 | 3 | 
                12 | 
            
        
            
                P53 (P53 DNA-binding domain) 
  | 
                29 | 10 | 
                29 | 
            
        
            
                PAP_central (Poly(A) polymerase central domain) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                PAP_RNA-bind (Poly(A) polymerase predicted RNA binding domain) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                ParB (ParB family) 
  | 
                4 | 2 | 
                3 | 
            
        
            
                PARP_regulatory (Poly A polymerase regulatory subunit) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                Parvo_coat (Parvovirus coat protein VP2) 
  | 
                5 | 5 | 
                5 | 
            
        
            
                Parvo_NS1 (Parvovirus non-structural protein NS1) 
  | 
                24 | 1 | 
                11 | 
            
        
            
                PAX ('Paired box' domain) 
  | 
                6 | 4 | 
                6 | 
            
        
            
                PAXNEB (PAXNEB protein) 
  | 
                36 | 4 | 
                0 | 
            
        
            
                PAZ (PAZ domain) 
  | 
                4 | 4 | 
                4 | 
            
        
            
                PC4 (Transcriptional Coactivator p15 (PC4)) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                PCRF (PCRF domain) 
  | 
                9 | 9 | 
                6 | 
            
        
            
                PD-C2-AF1 (POU domain, class 2, associating factor 1) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                PemK (PemK-like protein) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                Pencillinase_R (Penicillinase repressor) 
  | 
                8 | 4 | 
                8 | 
            
        
            
                Peptidase_A21 (Peptidase family A21) 
  | 
                8 | 1 | 
                0 | 
            
        
            
                Peptidase_A6 (Peptidase A6 family) 
  | 
                29 | 6 | 
                9 | 
            
        
            
                Peptidase_S24 (Peptidase S24-like) 
  | 
                2 | 1 | 
                0 | 
            
        
            
                Peripla_BP_1 (Periplasmic binding proteins and sugar binding domain of the LacI family) 
  | 
                42 | 28 | 
                0 | 
            
        
            
                Phage_CII (Bacteriophage CII protein) 
  | 
                4 | 1 | 
                4 | 
            
        
            
                Phage_coat (Phage PP7 coat protein) 
  | 
                12 | 1 | 
                12 | 
            
        
            
                Phage_endo_I (Phage endonuclease I) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                Phage_F (Capsid protein (F protein)) 
  | 
                6 | 3 | 
                5 | 
            
        
            
                Phage_G (Major spike protein (G protein)) 
  | 
                3 | 3 | 
                0 | 
            
        
            
                Phage_integrase (Phage integrase family) 
  | 
                66 | 25 | 
                66 | 
            
        
            
                Phage_integr_N (Phage integrase, N-terminal SAM-like domain) 
  | 
                10 | 4 | 
                10 | 
            
        
            
                Phage_integ_N (Bacteriophage lambda integrase, N-terminal domain) 
  | 
                6 | 2 | 
                6 | 
            
        
            
                Phe_tRNA-synt_N (Aminoacyl tRNA synthetase class II, N-terminal domain) 
  | 
                2 | 2 | 
                2 | 
            
        
            
                Phi-29_GP16_7 (Bacteriophage phi-29 early protein GP16.7) 
  | 
                6 | 1 | 
                4 | 
            
        
            
                Phi-29_GP4 (Phi-29-like late genes activator (early protein GP4)) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                PHP (PHP domain) 
  | 
                5 | 4 | 
                0 | 
            
        
            
                PIN (PIN domain) 
  | 
                8 | 2 | 
                0 | 
            
        
            
                Piwi (Piwi domain) 
  | 
                10 | 5 | 
                6 | 
            
        
            
                Plug_translocon (Plug domain of Sec61p) 
  | 
                3 | 3 | 
                0 | 
            
        
            
                PolC_DP2 (DNA polymerase II large subunit DP2) 
  | 
                2 | 2 | 
                0 | 
            
        
            
                PolyA_pol (Poly A polymerase head domain) 
  | 
                2 | 1 | 
                1 | 
            
        
            
                Pou (Pou domain - N-terminal to homeobox domain) 
  | 
                10 | 7 | 
                10 | 
            
        
            
                PPV_E1_C (Papillomavirus helicase) 
  | 
                23 | 3 | 
                22 | 
            
        
            
                PPV_E2_C (E2 (early) protein, C terminal) 
  | 
                7 | 4 | 
                7 | 
            
        
            
                ProRS-C_1 (Prolyl-tRNA synthetase, C-terminal) 
  | 
                4 | 2 | 
                0 | 
            
        
            
                Prox1 (Homeobox prospero-like protein (PROX1)) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                PseudoU_synth_1 (tRNA pseudouridine synthase) 
  | 
                18 | 3 | 
                13 | 
            
        
            
                PseudoU_synth_2 (RNA pseudouridylate synthase) 
  | 
                4 | 1 | 
                4 | 
            
        
            
                PTS-HPr (PTS HPr component phosphorylation site) 
  | 
                7 | 2 | 
                0 | 
            
        
            
                PUA (PUA domain) 
  | 
                7 | 6 | 
                5 | 
            
        
            
                PUF (Pumilio-family RNA binding repeat) 
  | 
                111 | 7 | 
                92 | 
            
        
            
                Pur_DNA_glyco (Methylpurine-DNA glycosylase (MPG)) 
  | 
                4 | 4 | 
                4 | 
            
        
            
                Pyr_excise (Pyrimidine dimer DNA glycosylase) 
  | 
                3 | 2 | 
                3 | 
            
        
            
                Rad4 (Rad4 transglutaminase-like domain) 
  | 
                2 | 2 | 
                2 | 
            
        
            
                Rad51 (Rad51) 
  | 
                36 | 4 | 
                0 | 
            
        
            
                Rap1-DNA-bind (Rap1, DNA-binding) 
  | 
                4 | 1 | 
                4 | 
            
        
            
                RdRP_1 (RNA dependent RNA polymerase) 
  | 
                36 | 16 | 
                36 | 
            
        
            
                RdRP_3 (Viral RNA dependent RNA polymerase) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                RdRP_4 (Viral RNA-directed RNA-polymerase) 
  | 
                8 | 7 | 
                8 | 
            
        
            
                RdRP_5 (Reovirus RNA-dependent RNA polymerase lambda 3) 
  | 
                4 | 4 | 
                4 | 
            
        
            
                RecA (recA bacterial DNA recombination protein) 
  | 
                36 | 4 | 
                36 | 
            
        
            
                Rep_3 (Initiator Replication protein) 
  | 
                4 | 3 | 
                4 | 
            
        
            
                Rep_N (Rep protein catalytic domain like) 
  | 
                7 | 2 | 
                7 | 
            
        
            
                ResIII (Type III restriction enzyme, res subunit) 
  | 
                6 | 4 | 
                5 | 
            
        
            
                Resolvase (Resolvase, N terminal domain) 
  | 
                14 | 5 | 
                12 | 
            
        
            
                RE_HindIII (HindIII restriction endonuclease) 
  | 
                4 | 1 | 
                4 | 
            
        
            
                RF-1 (RF-1 domain) 
  | 
                9 | 9 | 
                6 | 
            
        
            
                RFX_DNA_binding (RFX DNA-binding domain) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                Rhabdo_ncap (Rhabdovirus nucleocapsid protein) 
  | 
                49 | 2 | 
                27 | 
            
        
            
                RHD (Rel homology domain (RHD)) 
  | 
                56 | 24 | 
                56 | 
            
        
            
                RHH_1 (Ribbon-helix-helix protein, copG family) 
  | 
                20 | 3 | 
                20 | 
            
        
            
                Rho_N (Rho termination factor, N-terminal domain) 
  | 
                33 | 7 | 
                0 | 
            
        
            
                Rho_RNA_bind (Rho termination factor, RNA-binding domain) 
  | 
                35 | 7 | 
                32 | 
            
        
            
                Ribonuclease (ribonuclease) 
  | 
                11 | 6 | 
                11 | 
            
        
            
                Ribonuclease_3 (RNase3 domain) 
  | 
                19 | 9 | 
                8 | 
            
        
            
                Ribosomal_L1 (Ribosomal protein L1p/L10e family) 
  | 
                52 | 34 | 
                40 | 
            
        
            
                Ribosomal_L10 (Ribosomal protein L10) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                Ribosomal_L11 (Ribosomal protein L11, RNA binding domain) 
  | 
                122 | 118 | 
                97 | 
            
        
            
                Ribosomal_L11_N (Ribosomal protein L11, N-terminal domain) 
  | 
                74 | 74 | 
                47 | 
            
        
            
                Ribosomal_L12 (Ribosomal protein L7/L12 C-terminal domain) 
  | 
                11 | 6 | 
                3 | 
            
        
            
                Ribosomal_L13 (Ribosomal protein L13) 
  | 
                129 | 129 | 
                114 | 
            
        
            
                Ribosomal_L14 (Ribosomal protein L14p/L23e) 
  | 
                128 | 128 | 
                113 | 
            
        
            
                Ribosomal_L15 (Ribosomal protein L15 amino terminal region) 
  | 
                62 | 62 | 
                52 | 
            
        
            
                Ribosomal_L15e (Ribosomal L15) 
  | 
                58 | 58 | 
                57 | 
            
        
            
                Ribosomal_L16 (Ribosomal protein L16p/L10e) 
  | 
                132 | 132 | 
                115 | 
            
        
            
                Ribosomal_L17 (Ribosomal protein L17) 
  | 
                69 | 69 | 
                56 | 
            
        
            
                Ribosomal_L18p (Ribosomal L18p/L5e family) 
  | 
                127 | 127 | 
                114 | 
            
        
            
                Ribosomal_L19 (Ribosomal protein L19) 
  | 
                65 | 65 | 
                51 | 
            
        
            
                Ribosomal_L19e (Ribosomal protein L19e) 
  | 
                58 | 58 | 
                57 | 
            
        
            
                Ribosomal_L2 (Ribosomal Proteins L2, RNA binding domain) 
  | 
                131 | 131 | 
                119 | 
            
        
            
                Ribosomal_L20 (Ribosomal protein L20) 
  | 
                69 | 69 | 
                56 | 
            
        
            
                Ribosomal_L21e (Ribosomal protein L21e) 
  | 
                58 | 58 | 
                57 | 
            
        
            
                Ribosomal_L21p (Ribosomal prokaryotic L21 protein) 
  | 
                64 | 64 | 
                54 | 
            
        
            
                Ribosomal_L22 (Ribosomal protein L22p/L17e) 
  | 
                133 | 133 | 
                114 | 
            
        
            
                Ribosomal_L23 (Ribosomal protein L23) 
  | 
                133 | 131 | 
                115 | 
            
        
            
                Ribosomal_L24e (Ribosomal protein L24e) 
  | 
                63 | 63 | 
                61 | 
            
        
            
                Ribosomal_L25p (Ribosomal L25p family) 
  | 
                57 | 57 | 
                42 | 
            
        
            
                Ribosomal_L27 (Ribosomal L27 protein) 
  | 
                70 | 70 | 
                57 | 
            
        
            
                Ribosomal_L28 (Ribosomal L28 family) 
  | 
                24 | 24 | 
                22 | 
            
        
            
                Ribosomal_L29 (Ribosomal L29 protein) 
  | 
                131 | 131 | 
                114 | 
            
        
            
                Ribosomal_L2_C (Ribosomal Proteins L2, C-terminal domain) 
  | 
                131 | 131 | 
                117 | 
            
        
            
                Ribosomal_L3 (Ribosomal protein L3) 
  | 
                139 | 132 | 
                124 | 
            
        
            
                Ribosomal_L30 (Ribosomal protein L30p/L7e) 
  | 
                126 | 126 | 
                111 | 
            
        
            
                Ribosomal_L31 (Ribosomal protein L31) 
  | 
                37 | 37 | 
                25 | 
            
        
            
                Ribosomal_L31e (Ribosomal protein L31e) 
  | 
                60 | 60 | 
                59 | 
            
        
            
                Ribosomal_L32e (Ribosomal protein L32) 
  | 
                59 | 59 | 
                57 | 
            
        
            
                Ribosomal_L32p (Ribosomal L32p protein family) 
  | 
                74 | 74 | 
                55 | 
            
        
            
                Ribosomal_L33 (Ribosomal protein L33) 
  | 
                66 | 66 | 
                50 | 
            
        
            
                Ribosomal_L34 (Ribosomal protein L34) 
  | 
                65 | 65 | 
                49 | 
            
        
            
                Ribosomal_L35p (Ribosomal protein L35) 
  | 
                64 | 64 | 
                49 | 
            
        
            
                Ribosomal_L36 (Ribosomal protein L36) 
  | 
                56 | 56 | 
                44 | 
            
        
            
                Ribosomal_L37ae (Ribosomal L37ae protein family) 
  | 
                60 | 60 | 
                58 | 
            
        
            
                Ribosomal_L37e (Ribosomal protein L37e) 
  | 
                59 | 59 | 
                57 | 
            
        
            
                Ribosomal_L39 (Ribosomal L39 protein) 
  | 
                59 | 59 | 
                57 | 
            
        
            
                Ribosomal_L4 (Ribosomal protein L4/L1 family) 
  | 
                146 | 134 | 
                124 | 
            
        
            
                Ribosomal_L44 (Ribosomal protein L44) 
  | 
                59 | 59 | 
                57 | 
            
        
            
                Ribosomal_L5 (Ribosomal protein L5) 
  | 
                131 | 130 | 
                117 | 
            
        
            
                Ribosomal_L5_C (ribosomal L5P family C-terminus) 
  | 
                195 | 130 | 
                179 | 
            
        
            
                Ribosomal_L6 (Ribosomal protein L6) 
  | 
                260 | 130 | 
                227 | 
            
        
            
                Ribosomal_L7Ae (Ribosomal protein L7Ae/L30e/S12e/Gadd45 family) 
  | 
                72 | 67 | 
                70 | 
            
        
            
                Ribosomal_L9_C (Ribosomal protein L9, C-terminal domain) 
  | 
                51 | 51 | 
                1 | 
            
        
            
                Ribosomal_L9_N (Ribosomal protein L9, N-terminal domain) 
  | 
                64 | 64 | 
                49 | 
            
        
            
                Ribosomal_S10 (Ribosomal protein S10p/S20e) 
  | 
                92 | 92 | 
                80 | 
            
        
            
                Ribosomal_S11 (Ribosomal protein S11) 
  | 
                93 | 93 | 
                80 | 
            
        
            
                Ribosomal_S12 (Ribosomal protein S12) 
  | 
                104 | 104 | 
                81 | 
            
        
            
                Ribosomal_S13 (Ribosomal protein S13/S18) 
  | 
                95 | 94 | 
                82 | 
            
        
            
                Ribosomal_S14 (Ribosomal protein S14p/S29e) 
  | 
                92 | 92 | 
                80 | 
            
        
            
                Ribosomal_S15 (Ribosomal protein S15) 
  | 
                101 | 100 | 
                87 | 
            
        
            
                Ribosomal_S16 (Ribosomal protein S16) 
  | 
                91 | 91 | 
                79 | 
            
        
            
                Ribosomal_S17 (Ribosomal protein S17) 
  | 
                93 | 93 | 
                80 | 
            
        
            
                Ribosomal_S18 (Ribosomal protein S18) 
  | 
                95 | 94 | 
                80 | 
            
        
            
                Ribosomal_S19 (Ribosomal protein S19) 
  | 
                93 | 93 | 
                81 | 
            
        
            
                Ribosomal_S2 (Ribosomal protein S2) 
  | 
                93 | 93 | 
                82 | 
            
        
            
                Ribosomal_S20p (Ribosomal protein S20) 
  | 
                91 | 91 | 
                79 | 
            
        
            
                Ribosomal_S21 (Ribosomal protein S21) 
  | 
                25 | 25 | 
                23 | 
            
        
            
                Ribosomal_S30AE (Sigma 54 modulation protein / S30EA ribosomal protein) 
  | 
                5 | 5 | 
                5 | 
            
        
            
                Ribosomal_S3_C (Ribosomal protein S3, C-terminal domain) 
  | 
                92 | 92 | 
                80 | 
            
        
            
                Ribosomal_S3_N (Ribosomal protein S3, N-terminal domain) 
  | 
                91 | 91 | 
                79 | 
            
        
            
                Ribosomal_S4 (Ribosomal protein S4/S9 N-terminal domain) 
  | 
                94 | 94 | 
                81 | 
            
        
            
                Ribosomal_S5 (Ribosomal protein S5, N-terminal domain) 
  | 
                94 | 94 | 
                80 | 
            
        
            
                Ribosomal_S5_C (Ribosomal protein S5, C-terminal domain) 
  | 
                94 | 94 | 
                81 | 
            
        
            
                Ribosomal_S6 (Ribosomal protein S6) 
  | 
                95 | 94 | 
                82 | 
            
        
            
                Ribosomal_S7 (Ribosomal protein S7p/S5e) 
  | 
                97 | 96 | 
                82 | 
            
        
            
                Ribosomal_S8 (Ribosomal protein S8) 
  | 
                99 | 97 | 
                86 | 
            
        
            
                Ribosomal_S9 (Ribosomal protein S9/S16) 
  | 
                93 | 93 | 
                80 | 
            
        
            
                RIP (Ribosome inactivating protein) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                RMMBL (RNA-metabolising metallo-beta-lactamase) 
  | 
                4 | 1 | 
                2 | 
            
        
            
                RnaseA (Pancreatic ribonuclease) 
  | 
                11 | 7 | 
                11 | 
            
        
            
                RnaseH (RNase H) 
  | 
                28 | 13 | 
                24 | 
            
        
            
                RNaseH_C (T4 RNase H, C terminal) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                RNase_E_G (Ribonuclease E/G family) 
  | 
                7 | 4 | 
                7 | 
            
        
            
                RNase_PH (3' exoribonuclease family, domain 1) 
  | 
                4 | 2 | 
                4 | 
            
        
            
                RNase_PH_C (3' exoribonuclease family, domain 2) 
  | 
                4 | 2 | 
                2 | 
            
        
            
                RNA_ligase (RNA ligase) 
  | 
                8 | 2 | 
                4 | 
            
        
            
                RNA_pol (DNA-dependent RNA polymerase) 
  | 
                18 | 11 | 
                18 | 
            
        
            
                RNA_pol_A_bac (RNA polymerase Rpb3/RpoA insert domain) 
  | 
                39 | 28 | 
                0 | 
            
        
            
                RNA_pol_A_CTD (Bacterial RNA polymerase, alpha chain C terminal domain) 
  | 
                3 | 2 | 
                2 | 
            
        
            
                RNA_pol_L (RNA polymerase Rpb3/Rpb11 dimerisation domain) 
  | 
                64 | 28 | 
                0 | 
            
        
            
                RNA_POL_M_15KD (RNA polymerases M/15 Kd subunit) 
  | 
                25 | 24 | 
                0 | 
            
        
            
                RNA_pol_N (RNA polymerases N / 8 kDa subunit) 
  | 
                25 | 24 | 
                0 | 
            
        
            
                RNA_pol_Rpb1_1 (RNA polymerase Rpb1, domain 1) 
  | 
                39 | 28 | 
                37 | 
            
        
            
                RNA_pol_Rpb1_2 (RNA polymerase Rpb1, domain 2) 
  | 
                32 | 28 | 
                29 | 
            
        
            
                RNA_pol_Rpb1_3 (RNA polymerase Rpb1, domain 3) 
  | 
                32 | 28 | 
                0 | 
            
        
            
                RNA_pol_Rpb1_4 (RNA polymerase Rpb1, domain 4) 
  | 
                32 | 28 | 
                0 | 
            
        
            
                RNA_pol_Rpb1_5 (RNA polymerase Rpb1, domain 5) 
  | 
                37 | 28 | 
                30 | 
            
        
            
                RNA_pol_Rpb1_6 (RNA polymerase Rpb1, domain 6) 
  | 
                25 | 24 | 
                0 | 
            
        
            
                RNA_pol_Rpb1_7 (RNA polymerase Rpb1, domain 7) 
  | 
                25 | 24 | 
                0 | 
            
        
            
                RNA_pol_Rpb2_1 (RNA polymerase beta subunit) 
  | 
                53 | 28 | 
                18 | 
            
        
            
                RNA_pol_Rpb2_2 (RNA polymerase Rpb2, domain 2) 
  | 
                46 | 28 | 
                0 | 
            
        
            
                RNA_pol_Rpb2_3 (RNA polymerase Rpb2, domain 3) 
  | 
                32 | 28 | 
                23 | 
            
        
            
                RNA_pol_Rpb2_4 (RNA polymerase Rpb2, domain 4) 
  | 
                25 | 24 | 
                0 | 
            
        
            
                RNA_pol_Rpb2_45 (RNA polymerase beta subunit external 1 domain) 
  | 
                7 | 4 | 
                0 | 
            
        
            
                RNA_pol_Rpb2_5 (RNA polymerase Rpb2, domain 5) 
  | 
                25 | 24 | 
                0 | 
            
        
            
                RNA_pol_Rpb2_6 (RNA polymerase Rpb2, domain 6) 
  | 
                45 | 28 | 
                42 | 
            
        
            
                RNA_pol_Rpb2_7 (RNA polymerase Rpb2, domain 7) 
  | 
                32 | 28 | 
                27 | 
            
        
            
                RNA_pol_Rpb4 (RNA polymerase Rpb4) 
  | 
                13 | 12 | 
                0 | 
            
        
            
                RNA_pol_Rpb5_C (RNA polymerase Rpb5, C-terminal domain) 
  | 
                25 | 24 | 
                0 | 
            
        
            
                RNA_pol_Rpb5_N (RNA polymerase Rpb5, N-terminal domain) 
  | 
                25 | 24 | 
                1 | 
            
        
            
                RNA_pol_Rpb6 (RNA polymerase Rpb6) 
  | 
                32 | 28 | 
                0 | 
            
        
            
                RNA_pol_Rpb7_N (RNA polymerase Rpb7-like, N-terminal domain) 
  | 
                13 | 12 | 
                0 | 
            
        
            
                RNA_pol_Rpb8 (RNA polymerase Rpb8) 
  | 
                25 | 24 | 
                0 | 
            
        
            
                RNB (RNB domain) 
  | 
                2 | 2 | 
                2 | 
            
        
            
                Rota_NSP3 (Rotavirus non-structural protein NSP3) 
  | 
                8 | 1 | 
                8 | 
            
        
            
                Rpr2 (RNAse P Rpr2/Rpp21/SNM1 subunit domain) 
  | 
                5 | 1 | 
                4 | 
            
        
            
                RRF (Ribosome recycling factor) 
  | 
                14 | 13 | 
                9 | 
            
        
            
                RRM_1 (RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)) 
  | 
                131 | 69 | 
                109 | 
            
        
            
                RTP (Replication terminator protein) 
  | 
                9 | 4 | 
                9 | 
            
        
            
                Runt (Runt domain) 
  | 
                7 | 4 | 
                7 | 
            
        
            
                RusA (Endodeoxyribonuclease RusA) 
  | 
                4 | 1 | 
                2 | 
            
        
            
                RuvA_C (RuvA, C-terminal domain) 
  | 
                5 | 2 | 
                1 | 
            
        
            
                RuvA_N (RuvA N terminal domain) 
  | 
                5 | 2 | 
                0 | 
            
        
            
                RVT_1 (Reverse transcriptase (RNA-dependent DNA polymerase)) 
  | 
                50 | 29 | 
                30 | 
            
        
            
                RVT_connect (Reverse transcriptase connection domain) 
  | 
                28 | 10 | 
                22 | 
            
        
            
                RVT_thumb (Reverse transcriptase thumb domain) 
  | 
                28 | 10 | 
                14 | 
            
        
            
                S1 (S1 RNA binding domain) 
  | 
                19 | 17 | 
                3 | 
            
        
            
                S4 (S4 domain) 
  | 
                94 | 94 | 
                80 | 
            
        
            
                SAM_2 (SAM domain (Sterile alpha motif)) 
  | 
                3 | 3 | 
                3 | 
            
        
            
                SAP (SAP domain) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                SASP (Small, acid-soluble spore proteins, alpha/beta type) 
  | 
                3 | 1 | 
                3 | 
            
        
            
                SBP_bac_1 (Bacterial extracellular solute-binding protein) 
  | 
                1 | 1 | 
                0 | 
            
        
            
                SecE (SecE/Sec61-gamma subunits of protein translocation complex) 
  | 
                2 | 2 | 
                0 | 
            
        
            
                SecY (eubacterial secY protein) 
  | 
                3 | 3 | 
                3 | 
            
        
            
                SelB-wing_2 (Elongation factor SelB, winged helix) 
  | 
                4 | 2 | 
                4 | 
            
        
            
                SelB-wing_3 (Elongation factor SelB, winged helix) 
  | 
                9 | 4 | 
                8 | 
            
        
            
                SeqA (SeqA protein) 
  | 
                5 | 3 | 
                5 | 
            
        
            
                Seryl_tRNA_N (Seryl-tRNA synthetase N-terminal domain) 
  | 
                3 | 1 | 
                1 | 
            
        
            
                SH2 (SH2 domain) 
  | 
                2 | 2 | 
                0 | 
            
        
            
                Sigma54_DBD (Sigma-54, DNA binding domain) 
  | 
                2 | 2 | 
                2 | 
            
        
            
                Sigma70_r1_2 (Sigma-70 factor, region 1.2) 
  | 
                1 | 1 | 
                0 | 
            
        
            
                Sigma70_r2 (Sigma-70 region 2) 
  | 
                1 | 1 | 
                0 | 
            
        
            
                Sigma70_r3 (Sigma-70 region 3) 
  | 
                3 | 1 | 
                0 | 
            
        
            
                Sigma70_r4 (Sigma-70, region 4) 
  | 
                6 | 4 | 
                5 | 
            
        
            
                Sigma70_r4_2 (Sigma-70, region 4) 
  | 
                16 | 5 | 
                16 | 
            
        
            
                SmpB (SmpB protein) 
  | 
                9 | 4 | 
                6 | 
            
        
            
                SNF2_N (SNF2 family N-terminal domain) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                Spo0A_C (Sporulation initiation factor Spo0A C terminal) 
  | 
                4 | 1 | 
                4 | 
            
        
            
                SpoVT_AbrB (SpoVT / AbrB like domain) 
  | 
                4 | 1 | 
                4 | 
            
        
            
                SRF-TF (SRF-type transcription factor (DNA-binding and dimerisation domain)) 
  | 
                22 | 8 | 
                22 | 
            
        
            
                SRP-alpha_N (Signal recognition particle, alpha subunit, N-terminal) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                SRP14 (Signal recognition particle 14kD protein) 
  | 
                8 | 3 | 
                5 | 
            
        
            
                SRP19 (SRP19 protein) 
  | 
                9 | 8 | 
                9 | 
            
        
            
                SRP54 (SRP54-type protein, GTPase domain) 
  | 
                10 | 6 | 
                2 | 
            
        
            
                SRP54_N (SRP54-type protein, helical bundle domain) 
  | 
                10 | 6 | 
                3 | 
            
        
            
                SRP9 (Signal recognition particle 9 kDa protein (SRP9)) 
  | 
                4 | 3 | 
                3 | 
            
        
            
                SRPRB (Signal recognition particle receptor beta subunit) 
  | 
                2 | 1 | 
                0 | 
            
        
            
                SRP_SPB (Signal peptide binding domain) 
  | 
                45 | 21 | 
                25 | 
            
        
            
                SSB (Single-strand binding protein family) 
  | 
                6 | 2 | 
                5 | 
            
        
            
                STAT_alpha (STAT protein, all-alpha domain) 
  | 
                2 | 2 | 
                0 | 
            
        
            
                STAT_bind (STAT protein, DNA binding domain) 
  | 
                2 | 2 | 
                2 | 
            
        
            
                T-box (T-box) 
  | 
                4 | 2 | 
                4 | 
            
        
            
                T4-Gluco-transf (Bacteriophage T4 beta-glucosyltransferase) 
  | 
                8 | 4 | 
                1 | 
            
        
            
                TAF (TATA box binding protein associated factor (TAF)) 
  | 
                68 | 34 | 
                68 | 
            
        
            
                Taq-exonuc (Taq polymerase, exonuclease) 
  | 
                7 | 7 | 
                0 | 
            
        
            
                Tat (Transactivating regulatory protein (Tat)) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                TBP (Transcription factor TFIID (or TATA-binding protein, TBP)) 
  | 
                86 | 24 | 
                86 | 
            
        
            
                TEBP_beta (Telomere-binding protein beta subunit (TEBP beta)) 
  | 
                14 | 14 | 
                14 | 
            
        
            
                Telo_bind (Telomere-binding protein alpha subunit, central domain) 
  | 
                60 | 19 | 
                43 | 
            
        
            
                Ter (DNA replication terminus site-binding protein (Ter protein)) 
  | 
                4 | 4 | 
                4 | 
            
        
            
                TetR_C (Tetracyclin repressor, C-terminal all-alpha domain) 
  | 
                1 | 1 | 
                0 | 
            
        
            
                TetR_C_5 (QacR-like protein, C-terminal region) 
  | 
                4 | 1 | 
                0 | 
            
        
            
                TetR_N (Bacterial regulatory proteins, tetR family) 
  | 
                9 | 3 | 
                9 | 
            
        
            
                TFIIA (Transcription factor IIA, alpha/beta subunit) 
  | 
                8 | 4 | 
                4 | 
            
        
            
                TFIIA_gamma_C (Transcription initiation factor IIA, gamma subunit, beta-barrel domain) 
  | 
                4 | 4 | 
                0 | 
            
        
            
                TFIIA_gamma_N (Transcription initiation factor IIA, gamma subunit, helical domain) 
  | 
                4 | 4 | 
                0 | 
            
        
            
                TFIIB (Transcription factor TFIIB repeat) 
  | 
                16 | 4 | 
                15 | 
            
        
            
                TFIIB_Zn_Ribbon (TFIIB zinc-binding) 
  | 
                10 | 1 | 
                1 | 
            
        
            
                TFIIS_C (Transcription factor S-II (TFIIS)) 
  | 
                17 | 3 | 
                11 | 
            
        
            
                TFIIS_M (Transcription factor S-II (TFIIS), central domain) 
  | 
                1 | 1 | 
                0 | 
            
        
            
                TGS (TGS domain) 
  | 
                1 | 1 | 
                0 | 
            
        
            
                TGT (Queuine tRNA-ribosyltransferase) 
  | 
                10 | 3 | 
                6 | 
            
        
            
                Thioredoxin (Thioredoxin) 
  | 
                19 | 17 | 
                2 | 
            
        
            
                Thrombin_light (Thrombin light chain) 
  | 
                4 | 4 | 
                0 | 
            
        
            
                TIG (IPT/TIG domain) 
  | 
                60 | 28 | 
                42 | 
            
        
            
                TK (Thymidine kinase) 
  | 
                6 | 1 | 
                0 | 
            
        
            
                TMV_coat (Virus coat protein (TMV like)) 
  | 
                5 | 5 | 
                5 | 
            
        
            
                Tombus_P19 (Tombusvirus P19 core protein) 
  | 
                3 | 2 | 
                3 | 
            
        
            
                Topoisom_bac (DNA topoisomerase) 
  | 
                12 | 7 | 
                12 | 
            
        
            
                Topoisom_I (Eukaryotic DNA topoisomerase I, catalytic core) 
  | 
                18 | 18 | 
                18 | 
            
        
            
                Topoisom_I_N (Eukaryotic DNA topoisomerase I, DNA binding fragment) 
  | 
                16 | 16 | 
                16 | 
            
        
            
                Toprim (Toprim domain) 
  | 
                14 | 8 | 
                10 | 
            
        
            
                Toprim_N (DNA primase catalytic core, N-terminal domain) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                Tower (Tower) 
  | 
                1 | 1 | 
                0 | 
            
        
            
                TraI_2 (Putative helicase) 
  | 
                20 | 10 | 
                0 | 
            
        
            
                TRAM (TRAM domain) 
  | 
                2 | 1 | 
                2 | 
            
        
            
                Transposase_11 (Transposase DDE domain) 
  | 
                5 | 5 | 
                5 | 
            
        
            
                Transposase_17 (Transposase IS200 like) 
  | 
                12 | 6 | 
                12 | 
            
        
            
                Transposase_Tn5 (Transposase Tn5 dimerisation domain) 
  | 
                5 | 5 | 
                5 | 
            
        
            
                Trans_reg_C (Transcriptional regulatory protein, C terminal) 
  | 
                5 | 2 | 
                5 | 
            
        
            
                Trigger_N (Bacterial trigger factor protein (TF)) 
  | 
                3 | 3 | 
                2 | 
            
        
            
                TrmB (Sugar-specific transcriptional regulator TrmB) 
  | 
                4 | 2 | 
                4 | 
            
        
            
                tRNA-synt_1 (tRNA synthetases class I (I, L, M and V)) 
  | 
                57 | 11 | 
                19 | 
            
        
            
                tRNA-synt_1b (tRNA synthetases class I (W and Y)) 
  | 
                20 | 7 | 
                16 | 
            
        
            
                tRNA-synt_1c (tRNA synthetases class I (E and Q), catalytic domain) 
  | 
                29 | 22 | 
                29 | 
            
        
            
                tRNA-synt_1c_C (tRNA synthetases class I (E and Q), anti-codon binding domain) 
  | 
                15 | 15 | 
                14 | 
            
        
            
                tRNA-synt_1d (tRNA synthetases class I (R)) 
  | 
                2 | 2 | 
                2 | 
            
        
            
                tRNA-synt_1e (tRNA synthetases class I (C) catalytic domain) 
  | 
                13 | 4 | 
                1 | 
            
        
            
                tRNA-synt_1f (tRNA synthetases class I (K)) 
  | 
                5 | 3 | 
                1 | 
            
        
            
                tRNA-synt_1g (tRNA synthetases class I (M)) 
  | 
                46 | 12 | 
                16 | 
            
        
            
                tRNA-synt_2 (tRNA synthetases class II (D, K and N)) 
  | 
                9 | 5 | 
                8 | 
            
        
            
                tRNA-synt_2b (tRNA synthetase class II core domain (G, H, P, S and T)) 
  | 
                21 | 7 | 
                15 | 
            
        
            
                tRNA-synt_2d (tRNA synthetases class II core domain (F)) 
  | 
                18 | 6 | 
                1 | 
            
        
            
                tRNA_anti (OB-fold nucleic acid binding domain) 
  | 
                14 | 10 | 
                11 | 
            
        
            
                tRNA_bind (Putative tRNA binding domain) 
  | 
                2 | 2 | 
                0 | 
            
        
            
                tRNA_int_endo (tRNA intron endonuclease, catalytic C-terminal domain) 
  | 
                12 | 1 | 
                4 | 
            
        
            
                tRNA_int_endo_N (tRNA intron endonuclease, N-terminal domain) 
  | 
                4 | 1 | 
                0 | 
            
        
            
                tRNA_Me_trans (tRNA methyl transferase) 
  | 
                6 | 3 | 
                6 | 
            
        
            
                tRNA_NucTransf2 (tRNA nucleotidyltransferase, second domain) 
  | 
                28 | 21 | 
                26 | 
            
        
            
                tRNA_SAD (Threonyl and Alanyl tRNA synthetase second additional domain) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                tRNA_U5-meth_tr (tRNA (Uracil-5-)-methyltransferase) 
  | 
                6 | 2 | 
                4 | 
            
        
            
                TROVE (TROVE domain) 
  | 
                4 | 2 | 
                4 | 
            
        
            
                TrpBP (Tryptophan RNA-binding attenuator protein) 
  | 
                132 | 6 | 
                66 | 
            
        
            
                Trp_repressor (Trp repressor protein) 
  | 
                16 | 4 | 
                16 | 
            
        
            
                TruB-C_2 (Pseudouridine synthase II TruB, C-terminal) 
  | 
                2 | 2 | 
                0 | 
            
        
            
                TruB_N (TruB family pseudouridylate synthase (N terminal domain)) 
  | 
                9 | 7 | 
                9 | 
            
        
            
                TrwC (TrwC relaxase) 
  | 
                9 | 7 | 
                9 | 
            
        
            
                Trypsin (Trypsin) 
  | 
                4 | 4 | 
                4 | 
            
        
            
                Tymo_coat (Tymovirus coat protein) 
  | 
                6 | 2 | 
                4 | 
            
        
            
                Tyr-DNA_phospho (Tyrosyl-DNA phosphodiesterase) 
  | 
                16 | 8 | 
                16 | 
            
        
            
                T_Ag_DNA_bind (Origin of replication binding protein) 
  | 
                5 | 3 | 
                5 | 
            
        
            
                UDG (Uracil DNA glycosylase superfamily) 
  | 
                24 | 19 | 
                24 | 
            
        
            
                UPF0547 (Uncharacterised protein family UPF0547) 
  | 
                16 | 2 | 
                15 | 
            
        
            
                UVR (UvrB/uvrC motif) 
  | 
                4 | 2 | 
                0 | 
            
        
            
                UvrD-helicase (UvrD/REP helicase) 
  | 
                15 | 8 | 
                15 | 
            
        
            
                V-set (Immunoglobulin V-set domain) 
  | 
                37 | 15 | 
                20 | 
            
        
            
                Val_tRNA-synt_C (Valyl tRNA synthetase tRNA binding arm) 
  | 
                4 | 2 | 
                4 | 
            
        
            
                Viral_helicase1 (Viral (Superfamily 1) RNA helicase) 
  | 
                4 | 1 | 
                0 | 
            
        
            
                VirDNA-topo-I_N (Viral DNA topoisomerase I, N-terminal) 
  | 
                2 | 2 | 
                0 | 
            
        
            
                VP40 (Matrix protein VP40) 
  | 
                3 | 2 | 
                3 | 
            
        
            
                Vsr (DNA mismatch endonuclease Vsr) 
  | 
                2 | 2 | 
                2 | 
            
        
            
                WD40 (WD domain, G-beta repeat) 
  | 
                22 | 4 | 
                9 | 
            
        
            
                XPA_N (XPA protein N-terminal) 
  | 
                10 | 1 | 
                5 | 
            
        
            
                XPC-binding (XPC-binding domain) 
  | 
                2 | 2 | 
                0 | 
            
        
            
                XPG_I (XPG I-region) 
  | 
                3 | 2 | 
                1 | 
            
        
            
                XPG_N (XPG N-terminal domain) 
  | 
                3 | 2 | 
                3 | 
            
        
            
                YDG_SRA (YDG/SRA domain) 
  | 
                16 | 10 | 
                16 | 
            
        
            
                z-alpha (Adenosine deaminase z-alpha domain) 
  | 
                20 | 7 | 
                20 | 
            
        
            
                zf-C2H2 (Zinc finger, C2H2 type) 
  | 
                136 | 28 | 
                126 | 
            
        
            
                zf-C2HC (Zinc finger, C2HC type) 
  | 
                1 | 1 | 
                1 | 
            
        
            
                zf-C3HC4 (Zinc finger, C3HC4 type (RING finger)) 
  | 
                5 | 1 | 
                4 | 
            
        
            
                zf-C4 (Zinc finger, C4 type (two domains)) 
  | 
                52 | 26 | 
                52 | 
            
        
            
                zf-CCCH (Zinc finger C-x8-C-x5-C-x3-H type (and similar)) 
  | 
                10 | 2 | 
                4 | 
            
        
            
                zf-CCHC (Zinc knuckle) 
  | 
                20 | 14 | 
                20 | 
            
        
            
                zf-FPG_IleRS (Zinc finger found in FPG and IleRS) 
  | 
                23 | 22 | 
                23 | 
            
        
            
                Zn_clus (Fungal Zn(2)-Cys(6) binuclear cluster domain) 
  | 
                28 | 12 | 
                28 |