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: http://monkey.belozersky.msu.su/npidb/pdb/html_pfam/PF00178/main.html
Дата изменения: Wed Oct 1 16:19:00 2008 Дата индексирования: Tue Aug 18 06:21:40 2009 Кодировка: |
| General information | Species distribution | Numeration assumed | Sequence conservation | 3D conservation | Contacts with DNA |
The ETS domain is approximately 85-90 aa DNA-binding domain, that specifically interacts with sequences containing
the common core trinucleotide GGA. ETS domains contain three alpha-helixes and four-stranded
beta-sheets forming a winged helix-turn-helix (wHTH) topology.
The third alpha-helix is responsive to contact to the major groove of the DNA.
This domain is rich in positively-charged and aromatic residues.
Originally ETS domain was discovered in v-oncogene as part of a fusion protein gag-myb-ets expressed by a
transforming retrovirus
avian E26 (that is where the abbreviation ETS comes from) that induces a mixed erythroid/myeloid leukemia
in chickens, and later shown to be transduced from a cellular gene.
Many of the ETS proteins have been shown to be transcription activators,
ETS proteins have been implicated in regulation of gene expression during a variety of biological processes,
including growth control, transformation, T-cell activation, and developmental programs in many organisms.
Evidence is accumulating for a role for ETS family members in Drosophila development, Xenopus oocyte maturation,
lymphocyte differentiation, and viral infectious cycles. ETS domain is also involved in protein-protein
interactions with co-factors that help determine its biological
activity.Most Ets family proteins are nuclear targets for activation of Ras-MAP kinase
signaling pathway and some of them affect proliferation of cells by
regulating the immediate early response genes and other growth-related genes.