Документ взят из кэша поисковой машины. Адрес оригинального документа : http://mouse.belozersky.msu.ru/npidb/data/pdb_new/html_pfam/PF05204/index.files/intein_he.msf Дата изменения: Thu Jul 14 15:51:05 2011 Дата индексирования: Tue Feb 5 07:28:56 2013 Кодировка:

cont_type:
B= backbone
I= minor groove
J=major groove
H= hydrophobic interaction
W=water mediated and/or backbone
M= backbone and minor groove
G= major groove and hydrophobic interaction
P=backbone and hydrophobic interaction

catalyt.resi:
+ = catalytic active residue
W= coordinates water
M= coordinates metal
GDC ******** GeneDoc Multiple Sequence Alignment Editor ********
GDC 01153b0190000cffffffffffff000000000000000000808080c0c0c0ffff
GDC ff000000000000f43f000000000000f43f000000000000f03f0000000000
GDC 00f03f00A000300000190000cA54696d6573204e657720526f6d616e00A0
GDC 0640002000000000000000000000601444e000245510003535400044b520
GDC 00546595700064c49564d002851384a3047325f5a5947524f2c0d0a51384
GDC a3048325f39534143482c0d0a5138373447315f39534143482c0d0a51384
GDC a3047375f39534143482c0d0a5138373447345f39534143482c0d0a51384
GDC a3047395f39534143482c0d0a5138373447355f53414343412c0d0a51384
GDC a3048305f53414343412c0d0a5132503952335f44454248412c0d0a51364
GDC 2524d305f44454248412c0d0a484f5f59454153542c0d0a5139503938365
GDC f53414350532c0d0a51384a3253385f53414350412c0d0a5139503938345
GDC f53414342412c0d0a5139503938355f53414350532c0d0a5137303757345
GDC f4b4c5544452c0d0a5137303757395f43414e47412c0d0a5138373447325
GDC f53414345582c0d0a51384a3047385f53414345582c0d0a5138373447335
GDC f53414345582c0d0a564154415f43414e54522c0d0a5136434c36345f4b4
GDC c554c412c0d0a5138373447365f4b4c554c412c0d0a51384a3048335f4b4
GDC c554c412c0d0a51384a3048315f39534143482c0d0a51384a3047335f5a5
GDC 94742492c0d0a51384a3047345f5a594742412c0d0a51384a3047365f395
GDC 34143482c0d0a51384a3047355f39534143482c0d0a5139365559335f395
GDC 34143482c0d0a5132503951385f53414350532c0d0a5138373446395f534
GDC 14350532c0d0a5138373448305f59454153542c0d0a5138373448325f594
GDC 54153542c0d0a5138373448315f59454153542c0d0a5138365a37335f594
GDC 54153542c0d0a5138373447395f59454153542c0d0a5138365a35335f594
GDC 54153542c0d0a524759525f4d45544a412c0d0a564154415f59454153542
GDC c0d0a315644455f412c0d0a73735f7664652c0d0a646f6d61696e732c0d0
GDC a636174616c79745f726573692c0d0a636f6e745f747970652c0d0a73696
GDC 465636861696e2c0d0a646e615f636f6e6669726d2c0d0a6d75745f3c313
GDC 0255f6163746976652c0d0a324357383a412c0d0a73735f326377382c0d0
GDC a314451333a412c0d0a73735f316471332c0d0a73735f616c69676e293b0
GDC d0a00BBAABABA0000002a000a00020001B20AAA000d203a2000203a20000
GDC 0000000000059400000000000000000000c5058000000ffff00004758000
GDC 0ff00ff000041475358000000ffffff0056434147444e535450580000ff0
GDC 0ffff00484b525800ff00000000ff4544580000ff000000ff484b5245445
GDC 800ffffff0000ff48524551444e425a5800ff000000ff005957484b52455
GDC 1444e5354425a580000000000ff00494c56415800ff00008080804659574
GDC 858000000ff808080494c564341474d4659574854505800ffffff0000000
GDC c50580000000000000047580000000000000041434753580000000000000
GDC 0564147444e5354505800000000000000484b52580000000000000045445
GDC 800000000000000484b524544580000000000000048524551444e425a580
GDC 0000000000000435957484b524551444e5354425a5800000000000000494
GDC c56415800000000000000465957485800000000000000494c564341474d4
GDC 6595748545058000000000000000300ffffff00000000ffffff808080000
GDC 00000c0c0c00000ABBBBBBBBBBBBBB00ff00A00350001000100010001000
GDC 100010001000100010001000100010001000100010001000100010001000
GDC 100010001000100010001000100010001000100010001000100010001000
GDC 100010001000100010001000100010001000100010001000100010001000
GDC 1000100010001A0018AA000000000000000000000003A00ff00A00000000
GDC 008056400000000000805140000000000000494000000200000000000014
GDC 40A0000000098b20c4100000000102506410000000018980641000000007
GDC 8b10b4100AAABB00005374616e646172640046464c4c5353535359592a2a
GDC 43432a574c4c4c4c5050505048485151525252524949494d545454544e4e
GDC 4b4b5353525256565656414141414444454547474747002d2d2d2d2d2d2d
GDC 2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d4d2d
GDC 2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d00BBBB
GDC B00000000000000350000000000000000000000000000000000000000000
GDC 000000000000000000000000000000000000000000000000000000000000
GDC 000000000000000000000000000000000000000000000000000000000000
GDC 000000000000100000187000000ffffff00250000011b000000ffffff000
GDC 0024f000000ffff000000025f000000ffff000000027a000000ffff00000
GDC 00276000000ffff000000005e000000ffff000000005d000000ffff00000
GDC 0005b000000ffff0000000059000000ffff000000028e000000ffff00000
GDC 0028f000000ffffff0000006b000000ffff0000000297000000ffff00000
GDC 00290000000ffff0000000291000000ffffff0000019e000000ffffff000
GDC 00196000000ffffff0000019b000000ffffff0000019a000000ffffff000
GDC 00088000000ffff0000000084000000ffff000000009a000000ffff00000
GDC 000ac000000ffff00000000aa000000ffff00000000a7000000ffff00000
GDC 001ce000000ffffff000001de000000ffffff000000d8000000ffff00000
GDC 000d7000000ffff00000001f9000000ffffff000001f5000000ffffff000
GDC 0020f000000ffffff0000020e000000ffffff0000021b000000ffff00000
GDC 0021c000000ffff0000000217000000ffff0000000210000000ffffff000
GDC c0000024f000000ffff000000025f000000ffff000000027a000000fffff
GDC f00000276000000ffffff00000297000000ffffff00000290000000fffff
GDC f00000291000000ffffff0000019e000000ffffff00000196000000fffff
GDC f0000021c000000ffff000000021b000000ffff0000000217000000ffff0
GDC 0001b0000011b000000ffffff0000025f000000ffffff0000027a000000f
GDC fff0000000276000000ffff000000005e000000ffff000000005d000000f
GDC fff000000005b000000ffff0000000059000000ffff000000028e000000f
GDC fff000000028f000000ffffff0000006b000000ffff0000000297000000f
GDC fff0000000291000000ffffff00000290000000ffff000000019e000000f
GDC fffff00000088000000ffff0000000084000000ffffff0000009a000000f
GDC fff00000000ac000000ffff00000000aa000000ffff00000000a7000000f
GDC fff00000001de000000ffffff000000d7000000ffff00000000d8000000f
GDC fff00000001f9000000ffffff000001f5000000ffffff00000210000000f
GDC fffff000f0000024f000000ffff000000025f000000ffff0000000260000
GDC 000ffffff00000290000000ffff0000000187000000ffffff00000084000
GDC 000ffff0000000088000000ffff0000000196000000ffffff0000019a000
GDC 000ffffff0000019b000000ffffff000001ce000000ffffff000001de000
GDC 000ffffff0000021c000000ffff000000021b000000ffff0000000217000
GDC 000ffff00000000000000000000000003000000000000BBAB00350000000
GDC 000000000000000000000000000000000000000000000000000000000000
GDC 0000000002e0000000000000000000000000000000201b7B000000000000
GDC 594000000000000054400000000000004e4000DAAB000000ffffff030201
GDC 4445484b524e5153540000ff00ff0000024c49564d4659574147435000ff
GDC 000000ff0004014445484b520000ff00ff0000024e5153540000ff00ff80
GDC 00034c49564d46595700ff000000ff0004414700ff000000800008014445
GDC 0000ff00ff000002484b5200ffffffff0000034e510000ff00ff80000453
GDC 5400ffffffff8000054c495600ff000000ff000646595700ffffff00ff00
GDC 07414700ff0000008000084d4300ffffff0080000000000000Affffff808
GDC 08000A0305e3B000000000000594000000000000054400000000000004e4
GDC 000DAAB000000ffff800302014445484b524e5153540000ff00ff0000024
GDC c49564d4659574147435000ff000000ff0004014445484b520000ff00ff0
GDC 000024e5153540000ff00ff8000034c49564d46595700ff000000ff00044
GDC 14700ff0000008000080144450000ff00ff000002484b5200ffffffff000
GDC 0034e510000ff00ff800004535400ffffffff8000054c495600ff000000f
GDC f000646595700ffffff00ff0007414700ff0000008000084d4300ffffff0
GDC 08000000000534551002b51384a3047325f5a5947524f0051384a3048325
GDC f3953414348005138373447315f39534143480051384a3047375f3953414
GDC 348005138373447345f39534143480051384a3047395f395341434800513
GDC 8373447355f53414343410051384a3048305f53414343410051325039523
GDC 35f444542484100513642524d305f444542484100484f5f5945415354005
GDC 139503938365f53414350530051384a3253385f534143504100513950393
GDC 8345f5341434241005139503938355f5341435053005137303757345f4b4
GDC c554445005137303757395f43414e4741005138373447325f53414345580
GDC 051384a3047385f5341434558005138373447335f5341434558005641544
GDC 15f43414e5452005136434c36345f4b4c554c41005138373447365f4b4c5
GDC 54c410051384a3048335f4b4c554c410051384a3048315f3953414348005
GDC 1384a3047335f5a594742490051384a3047345f5a594742410051384a304
GDC 7365f39534143480051384a3047355f3953414348005139365559335f395
GDC 3414348005132503951385f5341435053005138373446395f53414350530
GDC 05138373448305f5945415354005138373448325f5945415354005138373
GDC 448315f5945415354005138365a37335f5945415354005138373447395f5
GDC 945415354005138365a35335f594541535400524759525f4d45544a41005
GDC 64154415f594541535400315644455f4100324357383a4100314451333a4
GDC 100Affffff80808000A0301bbB0000000000005940000000000000544000
GDC 00000000004e4000DAAB000000ff00000302014445484b524e5153540000
GDC ff00ff0000024c49564d4659574147435000ff000000ff0004014445484b
GDC 520000ff00ff0000024e5153540000ff00ff8000034c49564d46595700ff
GDC 000000ff0004414700ff0000008000080144450000ff00ff000002484b52
GDC 00ffffffff0000034e510000ff00ff800004535400ffffffff8000054c49
GDC 5600ff000000ff000646595700ffffff00ff0007414700ff000000800008
GDC 4d4300ffffff0080000000006c670000Affffff80808000A
intein_he.msf MSF: 899 Type: P January 13, 2009 18:00 Check: 5821 ..

Name: Q8J0G2_ZYGRO Len: 899 Check: 896 Weight: 1.00
Name: Q8J0H2_9SACH Len: 899 Check: 793 Weight: 1.00
Name: Q874G1_9SACH Len: 899 Check: 6357 Weight: 1.00
Name: Q8J0G7_9SACH Len: 899 Check: 6357 Weight: 1.00
Name: Q874G4_9SACH Len: 899 Check: 1247 Weight: 1.00
Name: Q8J0G9_9SACH Len: 899 Check: 2383 Weight: 1.00
Name: Q874G5_SACCA Len: 899 Check: 3514 Weight: 1.00
Name: Q8J0H0_SACCA Len: 899 Check: 3514 Weight: 1.00
Name: Q2P9R3_DEBHA Len: 899 Check: 3172 Weight: 1.00
Name: Q6BRM0_DEBHA Len: 899 Check: 3172 Weight: 1.00
Name: HO_YEAST Len: 899 Check: 2953 Weight: 1.00
Name: Q9P986_SACPS Len: 899 Check: 574 Weight: 1.00
Name: Q8J2S8_SACPA Len: 899 Check: 1905 Weight: 1.00
Name: Q9P984_SACBA Len: 899 Check: 2713 Weight: 1.00
Name: Q9P985_SACPS Len: 899 Check: 2478 Weight: 1.00
Name: Q707W4_KLUDE Len: 899 Check: 2007 Weight: 1.00
Name: Q707W9_CANGA Len: 899 Check: 9438 Weight: 1.00
Name: Q874G2_SACEX Len: 899 Check: 1285 Weight: 1.00
Name: Q8J0G8_SACEX Len: 899 Check: 1285 Weight: 1.00
Name: Q874G3_SACEX Len: 899 Check: 8016 Weight: 1.00
Name: VATA_CANTR Len: 899 Check: 8337 Weight: 1.00
Name: Q6CL64_KLULA Len: 899 Check: 9290 Weight: 1.00
Name: Q874G6_KLULA Len: 899 Check: 9290 Weight: 1.00
Name: Q8J0H3_KLULA Len: 899 Check: 9440 Weight: 1.00
Name: Q8J0H1_9SACH Len: 899 Check: 8353 Weight: 1.00
Name: Q8J0G3_ZYGBI Len: 899 Check: 6906 Weight: 1.00
Name: Q8J0G4_ZYGBA Len: 899 Check: 3082 Weight: 1.00
Name: Q8J0G6_9SACH Len: 899 Check: 110 Weight: 1.00
Name: Q8J0G5_9SACH Len: 899 Check: 6068 Weight: 1.00
Name: Q96UY3_9SACH Len: 899 Check: 7522 Weight: 1.00
Name: Q2P9Q8_SACPS Len: 899 Check: 7522 Weight: 1.00
Name: Q874F9_SACPS Len: 899 Check: 7522 Weight: 1.00
Name: Q874H0_YEAST Len: 899 Check: 7522 Weight: 1.00
Name: Q874H2_YEAST Len: 899 Check: 6752 Weight: 1.00
Name: Q874H1_YEAST Len: 899 Check: 6798 Weight: 1.00
Name: Q86Z73_YEAST Len: 899 Check: 7522 Weight: 1.00
Name: Q874G9_YEAST Len: 899 Check: 7543 Weight: 1.00
Name: Q86Z53_YEAST Len: 899 Check: 6716 Weight: 1.00
Name: RGYR_METJA Len: 899 Check: 4320 Weight: 1.00
Name: VATA_YEAST Len: 899 Check: 6798 Weight: 1.00
Name: 1VDE_A Len: 899 Check: 6798 Weight: 1.00
Name: ss_vde Len: 899 Check: 2305 Weight: 1.00
Name: domains Len: 899 Check: 1814 Weight: 1.00
Name: catalyt_resi Len: 899 Check: 738 Weight: 1.00
Name: cont_type Len: 899 Check: 2311 Weight: 1.00
Name: sidechain Len: 899 Check: 3845 Weight: 1.00
Name: dna_confirm Len: 899 Check: 4289 Weight: 1.00
Name: mut_<10%_active Len: 899 Check: 4628 Weight: 1.00
Name: 2CW8:A Len: 899 Check: 8406 Weight: 1.00
Name: ss_2cw8 Len: 899 Check: 9803 Weight: 1.00
Name: 1DQ3:A Len: 899 Check: 3256 Weight: 1.00
Name: ss_1dq3 Len: 899 Check: 9679 Weight: 1.00
Name: ss_align Len: 899 Check: 6477 Weight: 1.00

//

1 50
Q8J0G2_ZYGRO CFAKGTEVMM S...DGSIKE VEGIE..... .......... .....VG...
Q8J0H2_9SACH CFAKGTEVMM A...DSSIKN IEDIE..... .......... .....IG...
Q874G1_9SACH CFEKGTEVLM A...DGTDKV IEDIT..... .......... .....IG...
Q8J0G7_9SACH CFEKGTEVLM A...DGTDKV IEDIT..... .......... .....IG...
Q874G4_9SACH CFAKGTQVMM A...DGSDKS IEEIQ..... .......... .....IG...
Q8J0G9_9SACH CFAKGTQVMM A...DGSDKS IEEIQ..... .......... .....IG...
Q874G5_SACCA CFAKGTEVLM A...DGSDKA IEAIE..... .......... .....VG...
Q8J0H0_SACCA CFAKGTEVLM A...DGSDKA IEAIE..... .......... .....VG...
Q2P9R3_DEBHA CFAKGTEVLM A...DGSNKN IEEVQ..... .......... .....IG...
Q6BRM0_DEBHA CFAKGTEVLM A...DGSNKN IEEVQ..... .......... .....IG...
HO_YEAST MLSENTTILM A...NGEIKD IANVT..... .......... .....AN...
Q9P986_SACPS MLSENTTILM A...NGEIKD IANVT..... .......... .....AN...
Q8J2S8_SACPA MLSENTTILM A...SGEIKD IANVT..... .......... .....AN...
Q9P984_SACBA MLSENTTILM A...NGEIKD IANVT..... .......... .....AN...
Q9P985_SACPS MLSENTTILM A...NGEIKD IANVT..... .......... .....AN...
Q707W4_KLUDE MFDINTTVVM A...NGEIKK VCELT..... .......... .....VN...
Q707W9_CANGA MFEKGTFILM A...DGHLED ISAIK..... .......... .....SN...
Q874G2_SACEX CFAKGTQVMM A...DGTDKS IEDIQ..... .......... .....LG...
Q8J0G8_SACEX CFAKGTQVMM A...DGTDKS IEDIQ..... .......... .....LG...
Q874G3_SACEX CFAKGTQVMM A...DGSDKS IEDIQ..... .......... .....LG...
VATA_CANTR CFTKGTQVMM A...DGADKS IESIE..... .......... .....VG...
Q6CL64_KLULA CFSKGTEVMM G...DGKDEL IENIQ..... .......... .....VG...
Q874G6_KLULA CFSKGTEVMM G...DGKDEL IENIQ..... .......... .....VG...
Q8J0H3_KLULA CFSKGTEVMM G...DGKDEL IENIQ..... .......... .....VG...
Q8J0H1_9SACH CFAKGTTVLM A...DGSIEC IENIK..... .......... .....IG...
Q8J0G3_ZYGBI CFAKGTEVMM S...DASVKT VESVK..... .......... .....VG...
Q8J0G4_ZYGBA CFAKGTEVMM H...DGSVKA IETIE..... .......... .....AG...
Q8J0G6_9SACH CFAKGTPVMM H...DGSVKA IETIN..... .......... .....VG...
Q8J0G5_9SACH CFAKGTKVLL H...DGSLRA IESIE..... .......... .....VG...
Q96UY3_9SACH CFAKGTNVLM A...DGSIEC IENIE..... .......... .....VG...
Q2P9Q8_SACPS CFAKGTNVLM A...DGSIEC IENIE..... .......... .....VG...
Q874F9_SACPS CFAKGTNVLM A...DGSIEC IENIE..... .......... .....VG...
Q874H0_YEAST CFAKGTNVLM A...DGSIEC IENIE..... .......... .....VG...
Q874H2_YEAST CFAKGTNVLM A...DGSIEC IENIE..... .......... .....VG...
Q874H1_YEAST CFAKGTNVLM A...DGSIEC IENIE..... .......... .....VG...
Q86Z73_YEAST CFAKGTNVLM A...DGSIEC IENIE..... .......... .....VG...
Q874G9_YEAST CFAKGTNVLM A...DGSIEC IENIE..... .......... .....VG...
Q86Z53_YEAST CFAKGTNVLM A...DGSIEC IENIE..... .......... .....VG...
RGYR_METJA .FELGLCLTP DTYVVLGDGR IETIE..... .......... ..........
VATA_YEAST CFAKGTNVLM A...DGSIEC IENIE..... .......... .....VG...
1VDE_A CFAKGTNVLM A...DGSIEC IENIE..... .......... .....VG...
ss_vde ......SSS. .......SSS HHH....... .......... ..........
domains <......... .......... .......... .......... ..........
catalyt_resi .......... .......... .......... .......... ..........
cont_type .......... .......... .......... .......... ..........
sidechain .......... .......... .......... .......... ..........
dna_confirm .......... .......... .......... .......... ..........
mut_<10%_active .......... .......... .......... .......... ..........
2CW8:A SILPEEWLPV LEEGEVHFVR IGELIDRMME ENAGKVKREG ETEVLEVS..
ss_2cw8 ......SSSS SS..SSSSSS HHHHHHHHHH ..HHH.SSS. .SSSSS....
1DQ3:A CIDGKAKIIF ENEGEEHLTT MEEMYERYKH LGEFYD.EEY NRWGIDVSNV
ss_1dq3 .SS...SSSS S....SSSSS HHHHHHHHHH H..SSS.... .SSSSS....
ss_align ++++++++++ +...++++++ +++++..... .......... .....++...

51 100
Q8J0G2_ZYGRO .QEVMGK... ...DGKPREV VGTPSGRE.. ..KMYKVSHK TAHRAHKSD.
Q8J0H2_9SACH .DLVMGQ... ...DGQPREV TQLPRGSD.. ..KMYKVNEI NEN.......
Q874G1_9SACH .EQVMGK... ...DGQPREV VGLPRGKM.. ..TMYQVCHK ATEQ......
Q8J0G7_9SACH .EQVMGK... ...DGQPREV VGLPRGKM.. ..TMYQVCHK ATEQ......
Q874G4_9SACH .EQVMGK... ...DGNPRTV IALPRGKE.. ..TMYEVCHI TPHR......
Q8J0G9_9SACH .EQVMGK... ...DGNPRTV IALPRGKE.. ..TMYEVCHI TPHR......
Q874G5_SACCA .EQVMGK... ...DGAPRTV IALPRGTE.. ..TMYEVCHT TQHR......
Q8J0H0_SACCA .EQVMGK... ...DGAPRTV IALPRGTE.. ..TMYEVCHT TQHR......
Q2P9R3_DEBHA .ESVLGK... ...DGEARNV VALPRGNE.. ..TMYEINES TPEE......
Q6BRM0_DEBHA .ESVLGK... ...DGEARNV VALPRGNE.. ..TMYEINES TPEE......
HO_YEAST .SYVMCA... ...DGSAARV INVTQGYQ.. ..KIYNIQQK TKHRAFEGEP
Q9P986_SACPS .SYVMCA... ...DGSAARV INVTQGYQ.. ..EIYNIQQK TKHRAFEGEP
Q8J2S8_SACPA .SYVMCA... ...DGSAARV VNVTQGYQ.. ..KIYNIQQK TKHRAFEGEP
Q9P984_SACBA .SYVMCE... ...DGSAARV ISVTQGCQ.. ..KIYNIQQK TKHRAFEGEP
Q9P985_SACPS .SYVMCE... ...DGSAARV ISVTQGCQ.. ..KIYNIQQK TKHRAFEGEP
Q707W4_KLUDE .SLVMCD... ...DGTPARI THISSAHH.. ..TTYEIYQK TKHRANEGEP
Q707W9_CANGA .SYVMCE... ...DGTPGRV AYTTKAKQ.. ..TIYEIVQK TKHRANEGEP
Q874G2_SACEX .ENVMGK... ...DGTPRTV ISLPRGKE.. ..TMYEVCHS S.IKG.....
Q8J0G8_SACEX .ENVMGK... ...DGTPRTV ISLPRGKE.. ..TMYEVCHS S.IKG.....
Q874G3_SACEX .ENVMGK... ...DGTPRTV ISLPRGKE.. ..TMYEVCHS S.TKG.....
VATA_CANTR .DKVMGK... ...DGMPREV VGLPRGYD.. ..DMYKVRQL SSTRR.....
Q6CL64_KLULA .DEVMGR... ...DGLPRQV VGLPRGHD.. ..DMYQVTEK SEDNE.....
Q874G6_KLULA .DEVMGR... ...DGLPRQV VGLPRGHD.. ..DMYQVTEK SEDNE.....
Q8J0H3_KLULA .DEVMGR... ...DGLPRQV VGLPRGHD.. ..DMYQVTEK SEDNE.....
Q8J0H1_9SACH .DKVMGK... ...DGKPREV IKLPRGNE.. ..TMYSVVQK SQHRAHKTD.
Q8J0G3_ZYGBI .EQVMGK... ...DGKPRKV VATPSGCE.. ..KMYKVTQK VAHKRTHT..
Q8J0G4_ZYGBA .EAVMGT... ...DGQPRKV VGLPRGRE.. ..VMYKVSQK TAHRVHKTD.
Q8J0G6_9SACH .EEVMGA... ...DGLGRKI VGLPRGRE.. ..VMYKVSQK TEHRAYETD.
Q8J0G5_9SACH .EDVMGV... ...DGERRKV VGLPRGRE.. ..VMYKVSQK TTNRAHETA.
Q96UY3_9SACH .NKVMGK... ...DGRPREV IKLPRGSE.. ..TMYSVVQK SQHRAHKSD.
Q2P9Q8_SACPS .NKVMGK... ...DGRPREV IKLPRGSE.. ..TMYSVVQK SQHRAHKSD.
Q874F9_SACPS .NKVMGK... ...DGRPREV IKLPRGSE.. ..TMYSVVQK SQHRAHKSD.
Q874H0_YEAST .NKVMGK... ...DGRPREV IKLPRGSE.. ..TMYSVVQK SQHRAHKSD.
Q874H2_YEAST .NKVMGK... ...DGRPREV IKLPRGRE.. ..TMYSVVQK SQHRAHKSD.
Q874H1_YEAST .NKVMGK... ...DGRPREV IKLPRGRE.. ..TMYSVVQK SQHRAHKSD.
Q86Z73_YEAST .NKVMGK... ...DGRPREV IKLPRGSE.. ..TMYSVVQK SQHRAHKSD.
Q874G9_YEAST .NKVMGK... ...DGRPREV IKLPRGRE.. ..TMYSVVQK SQHRAHXSD.
Q86Z53_YEAST .NKVMGK... ...DGRPREV IKLPRGRE.. ..TMYSVVQK SQHRAHKSD.
RGYR_METJA .DIVNAK... ...ERNVLSL DLDNLSIK.. ..IDTAIKFW KLRYNGNL..
VATA_YEAST .NKVMGK... ...DGRPREV IKLPRGRE.. ..TMYSVVQK SQHRAHKSD.
1VDE_A .NKVMGK... ...DGRPREV IKLPRGRE.. ..TMYSVVQK SQHRAHKSD.
ss_vde ..SSS..... ......SSSS SS..SSSS.. ...SSSSSS. ..........
domains .......... .......SPL ICING..... .......... ..........
catalyt_resi .......... .......... .......... .......... ..........
cont_type .......... .......... .......... .........B .M.BB.....
sidechain .......... .......... .......... .........+ ..........
dna_confirm .......... .......... .......... .........+ .+.++.....
mut_<10%_active .......... .......... .......... .......... ..........
2CW8:A GLEVPSFNRR TNKAELKRV. KALIRHDYS. .GKVYTIRLK S.........
ss_2cw8 .SSSSSS... ...SSSSSS. SSSSSSSSS. .SSSSSSSS. ..........
1DQ3:A PIYVKSFDPE SKRVVKGKV. NVIWKYELGK DVTKYEIITN K.........
ss_1dq3 ..SSSSSS.. ..SSSSSSS. SSSSSSSS.. ...SSSSSS. ..........
ss_align .++++++... ...++++++. +++.++++.. ..++++++++ +.........

101 150
Q8J0G2_ZYGRO .....STSER FGLFEYTCNA THKLVVRTSR SCRPLVRNIQ GTDYVEVCLF
Q8J0H2_9SACH ........ST SELFSFVCNA THQLIVRTPR NIKVQTRIID GIECNEIVYT
Q874G1_9SACH ........NE IALMDYVCSG NHKFVLVTPQ NVKITEHMLR GKMYTSVNYF
Q8J0G7_9SACH ........NE IALMDYVCSG NHKFVLVTPQ NVKITEHMLR GKMYTSVNYF
Q874G4_9SACH ....TTSGEN FGVMDYVCSG NHKLVLRTPQ NVTLTTHELD GQTYTNVSYF
Q8J0G9_9SACH ....TTSGEN FGVMDYVCSG NHKLVLRTPQ NVTLTTHELD GQTYTNVSYF
Q874G5_SACCA .....NGNEK FGLMNYVCSG NHKLVLRTPQ LIRTTIHELR GKHYTSVTFF
Q8J0H0_SACCA .....NGNEK FGLMNYVCSG NHKLVLRTPQ LIRTTIHELR GKHYTSVTFF
Q2P9R3_DEBHA .......EAD LARIAFTCNA KHELVVNTKQ DIAVEQN... .....CVTYF
Q6BRM0_DEBHA .......EAD LARIAFTCNA KHELVVNTKQ DIAVEQN... .....CVTYF
HO_YEAST GRLDPRRRTV YQRLALQCTA GHKLSVRVPT KPLL.EKSGR NATKYKVRWR
Q9P986_SACPS GRLDPRRRTV YQRLALQCTA GHKLSVRVPT KPLL.EKSGR NATKYKVRWR
Q8J2S8_SACPA GRLDPRRRTV YQRLALQCTA GHKLSVRVPT KPLL.EKSGR NATKYKVRWR
Q9P984_SACBA GRLDPRRRTI YQRLNLQCTA GHKLSVRVPT KPLL.EKSGR SATKYKVRWR
Q9P985_SACPS GRLDPRRRTI YQRLDLQCTA GHKLSVRVPT KPLL.EKSGR SATKYKVRWR
Q707W4_KLUDE GRLDPRRKTV YQRLGFNCTG SHLIPLRVPA IACL.ENSTI KPNLT.VRWR
Q707W9_CANGA GRLDPRRRTV YNRLGFNCSA THKLVLKTPS IPTL.ENNPR RPNLT.VKWR
Q874G2_SACEX .......TTN ETLMNYVCSG NHKIVMQTPQ QIGITEHAID GKTYTSVSYF
Q8J0G8_SACEX .......TTN ETLMNYVCSG NHKIVMQTPQ QIGITEHAID GKTYTSVSYF
Q874G3_SACEX .......TTK DTLMNYVCSG NHKIVMQTPQ QIGITEHGID GKTYTSVSYF
VATA_CANTR ......NAKS EGLMDFTVSA DHKLILKTKQ DVKIATRKIG GNTYTGVTFY
Q6CL64_KLULA .......... TAKISFQCNS SHKLVLVTPQ DIRLTESKEK V....TVAFN
Q874G6_KLULA .......... TAKISFQCNS SHKLVLVTPQ DIRLTESKEK V....TVAFN
Q8J0H3_KLULA .......... TAKISFQCNS SHKLVLVTPQ DIRLTESKEK V....TVAFN
Q8J0H1_9SACH .....SSREV PDLLKFTCNS THELVVRTPR SVRRVSRTMK GVEYFEVISF
Q8J0G3_ZYGBI ......LNEP RGLSEYTCNA THKLVVRTPR ICRSVIRKFK GTNYIDVIFF
Q8J0G4_ZYGBA ....ETRAAP VALFEYNCNA THKLVVRTPR SCRSITRKMQ GVDYNEVIFF
Q8J0G6_9SACH ....ETRSAP VGLFEYTCNA THKLVVRTPR SCRTLNRTMK GVEYYEVVFF
Q8J0G5_9SACH ....ETRSEP LGLFEYTCNA THKLVVRTPR SCRLLTRNEN GADYYDVAFF
Q96UY3_9SACH .....SSREM PELLKFTCNA THELVVRTPR SVRRLSRTIK GVEYFEVITF
Q2P9Q8_SACPS .....SSREM PELLKFTCNA THELVVRTPR SVRRLSRTIK GVEYFEVITF
Q874F9_SACPS .....SSREM PELLKFTCNA THELVVRTPR SVRRLSRTIK GVEYFEVITF
Q874H0_YEAST .....SSREM PELLKFTCNA THELVVRTPR SVRRLSRTIK GVEYFEVITF
Q874H2_YEAST .....SSREV PELLKFTCNA THELVVRTPR SVRRLSRTIK GVEYFEVITF
Q874H1_YEAST .....SSREV PELLKFTCNA THELVVRTPR SVRRLSRTIK GVEYFEVITF
Q86Z73_YEAST .....SSREM PELLKFTCNA THELVVRTPR SVRRLSRTIK GVEYFEVITF
Q874G9_YEAST .....SSREV PELLKFTCNA THELVVRTPR SVRRLSRTIK GVEYFEVITF
Q86Z53_YEAST .....SSREV PELLKFTCNA THELVVRTPR SVRRLSRTIK GVEYFEVITF
RGYR_METJA .....SKITL SNNYELKATP DHCLLVLRDN QLKWIPAKDI KENDYIAMPF
VATA_YEAST .....SSREV PELLKFTCNA THELVVRTPR SVRRLSRTIK GVEYFEVITF
1VDE_A .....SSREV PELLKFTCNA THELVVRTPR SVRRLSRTIK GVEYFEVITF
ss_vde .......... ....SSSSS. ..SSSSSSS. .SS....... ......SSSS
domains .......... .......... ....><.... .......... ..........
catalyt_resi .......... .......... .......... .......... ..........
cont_type .......B.. .......... .......... ..J.H.G... ..........
sidechain .......+.. .......... .......... ..+.+.+... ..........
dna_confirm .......+.. .......... .......... ......+... ..........
mut_<10%_active .......... .......... .......... ..+...+... ..........
2CW8:A .......... ..GRRIKITS GHSLFSVRN. .......... ..........
ss_2cw8 .......... ....SSSSS. ..SSSSSS.. .......... ..........
1DQ3:A .......... ..GTKILTSP WHPFFVLTPD .......... ..........
ss_1dq3 .......... ....SSSS.. ..SSSSS... .......... ..........
ss_align .......... ..++++++++ ++++++++.+ .......... ..........

151 200
Q8J0G2_ZYGRO NMTKKTLE.D GRVIDIVEET SDFYPAVEGP EKALRILKEY AEADG..GKE
Q8J0H2_9SACH DLFKEITE.D ARIIELIKEV SKIYPVSEGM DDVQEFVSQY NKSLE....D
Q874G1_9SACH VANDFE...N G.QVVKLRTK TFQHDIHGGA DGAKVEAQKF ASTID...LS
Q8J0G7_9SACH VANDFE...N G.QVVKLRTK TFQHDIHGGA DGAKVEAQKF ASTID...LS
Q874G4_9SACH ALEESA...Y G.QIVKKKTK SYQHQRHGGK QETEKKVNEF LATIN...PD
Q8J0G9_9SACH ALEESA...Y G.QIVXKKTK SYQHQRHGGK QETEKKVNEF LATIN...PD
Q874G5_SACCA VTEKSA...N G.TIVKQRTK TFQHEFHGGE EAATKLAADF ASTID...PK
Q8J0H0_SACCA VTEKSA...N G.TIVKQRTK TFQHEFHGGE EAATKLAADF ASTID...PK
Q2P9R3_DEBHA ALESVTDEAN GREFSVVKSQ TKTFEESS.. .....MAKEF ASTIS...KN
Q6BRM0_DEBHA ALESVTDEAN GREFSVVKSQ TKTFEESS.. .....MAKEF ASTIS...KN
HO_YEAST NLQQCQTL.D GRIIIIPKNH HKTFPMTVEG EFAAKRFIEE MERSK...GE
Q9P986_SACPS NLQQCQTL.D GKIIIIPKNH HKTFQMTVEG EFAAKRFIEE MERSK...GE
Q8J2S8_SACPA NLQQCQTL.D GRIITIPKNH HKTFPMTVEG EYAAKRFIEE MERSK...GE
Q9P984_SACBA NLQQCQTL.D GRIITIPKNH HKTFPMTVEG EFAAKRFIEE MELLK...GE
Q9P985_SACPS NLQQCQTL.D GRIITIPKNH HKTFPMTVEG EFAAKCFIEE MELLK...GE
Q707W4_KLUDE CLEDVVTN.D GRLISIPKNH HKNFPKTQEG FLLADNFIKE RSAIT...GD
Q707W9_CANGA CLEEILTT.D GRAITVPKNH HKNFPKTKEG QLQAQNFMRD KRLIW...GP
Q874G2_SACEX ALRDSQ...D GYPIVKKLTK SFEHQQNGGK EQTLITVNNF VASLK...SE
Q8J0G8_SACEX ALRDSQ...D GYPIVKKLTK SFEHQQNGGK EQTLITVNNF VASLK...SE
Q874G3_SACEX ALRDSQ...H GYPIVKKLTK SFEHQQHGGK EQTLITVNNF VSSLK...SE
VATA_CANTR VLEKTK...T GIELVKAKTK VFGHHIHGQN GAEEKAATFA AGIDS...KE
Q6CL64_KLULA RLADISVG.N GTESRTVRLV ERAEKSFANA ESNQAIINAA EFVTT.IDTT
Q874G6_KLULA RLADISVG.N GTESRTVRLV ERAEKSFANA ESNQAIINAA EFVTT.IDTT
Q8J0H3_KLULA RLADISVG.N GTESRTVRLV ERAEKSFANA ESNQAIINAA EFVTT.IDTT
Q8J0H1_9SACH EMVQKKVP.D GRIIELVKEV SKSYPASEGP ERADELVESY RKAST...KP
Q8J0G3_ZYGBI NKVKGSVE.D GRVIDIVQEA SMSYPAVEGP ERALRAIKEY AEADG..ARE
Q8J0G4_ZYGBA DLKKKKLE.D GREIEIVKEV SRSYPAAEGA EKAAQMVKDY YDAAR..GKE
Q8J0G6_9SACH DLAKEKLK.D GREIEVVKEI SRSYPVTEGP ERAAEIMKEY QEAGA..GKQ
Q8J0G5_9SACH DLVKTKLK.D GREIEIVKEM SNSYLATEGP EKAAQMVKEY QEASE..GKE
Q96UY3_9SACH EMGQKKAP.D GRIVELVKEV SKSYPVSEGP ERANELVESY RKASN...KA
Q2P9Q8_SACPS EMGQKKAP.D GRIVELVKEV SKSYPVSEGP ERANELVESY RKASN...KA
Q874F9_SACPS EMGQKKAP.D GRIVELVKEV SKSYPVSEGP ERANELVESY RKASN...KA
Q874H0_YEAST EMGQKKAP.D GRIVELVKEV SKSYPVSEGP ERANELVESY RKASN...KA
Q874H2_YEAST EMGQKKAP.D GRIVELVKEV SKSYPISEGP ERANELVESY RKASN...KA
Q874H1_YEAST EMGQKKAP.D GRIVELVKEV SKSYPISEGP ERANELVESY RKASN...KA
Q86Z73_YEAST EMGQKKAP.D GRIVELVKEV SKSYPVSEGP ERANELVESY RKASN...KA
Q874G9_YEAST EMGQKKAP.D GRIVELVKEV SKSYPISEGP ERANELVESY RKASN...KA
Q86Z53_YEAST EMGQKKAP.D GRIVELVKEV SKSYPISEGP ERANELVESY RKASN...KA
RGYR_METJA NYKVERKPIS LLNLLKYLDI TDVLIEFDEN STIFEKIAEY IRNNIKTSTK
VATA_YEAST EMGQKKAP.D GRIVELVKEV SKSYPISEGP ERANELVESY RKASN...KA
1VDE_A EMGQKKAP.D GRIVELVKEV SKSYPISEGP ERANELVESY RKASN...KA
ss_vde SSSSSS.... ..SSSSSSSS SS........ .HHHHHHHHH HH........
domains .......... .....DNA.B INDING.... .......... ..........
catalyt_resi .......... .......... .......... .......... ..........
cont_type ....W..... .......B.. B.B....... .......... ..........
sidechain ....+..... .......+.. .......... .......... ..........
dna_confirm ....+..... .......+.. +.+....... .......... ..........
mut_<10%_active .......... .......... .......... .......... ..........
2CW8:A .......... .......... .......... .......... ..........
ss_2cw8 .......... .......... .......... .......... ..........
1DQ3:A .......... .......... .......... .......... ..........
ss_1dq3 .......... .......... .......... .......... ..........
ss_align .......... .......... .......... .......... ..........

201 250
Q8J0G2_ZYGRO YFEWTIEARD VALLSAQVRK ATYQLSAP.. .......... ..........
Q8J0H2_9SACH YFQWTVEPRD INRLTESIRE ATYQVYAP.. .......... ..........
Q874G1_9SACH PISWEIEASK YVELDVNVRN ATTQLINP.. .......... ..........
Q8J0G7_9SACH PISWEIEASK YVELDVNVRN ATTQLINP.. .......... ..........
Q874G4_9SACH SIEWDVEAKD YKKLGYDVKK SSHQMINP.. .......... ..........
Q8J0G9_9SACH SIEWDVEAKD YKKLGYNVKK SSHQMINP.. .......... ..........
Q874G5_SACCA HIDWDIEAKD YKQLDHYVKK SSYQMINP.. .......... ..........
Q8J0H0_SACCA HIDWDIEAKD YKQLDHYVKK SSYQMINP.. .......... ..........
Q2P9R3_DEBHA SIDWTIEARD VGHMSDDVRC ATQQSWAP.. .......... ..........
Q6BRM0_DEBHA SIDWTIEARD VGHMSDDVRC ATQQSWAP.. .......... ..........
HO_YEAST YFNFDIEVRD LDYLDAQLRI SSCIRFGP.. .......... ..........
Q9P986_SACPS YFNFDIEVRD LDYLDAQLRI SSCIRFGP.. .......... ..........
Q8J2S8_SACPA YFNFDIEVRD LDYLDAQLRI SSCIRFGP.. .......... ..........
Q9P984_SACBA YFNFDIEVRD LDYLDAQLRI SSCIRFSP.. .......... ..........
Q9P985_SACPS YFNFDIEVRD LDYLDAQLRI SSCIRFSP.. .......... ..........
Q707W4_KLUDE YIDYLIEVRD LDYLDTSMRV TSALKCSP.. .......... ..........
Q707W9_CANGA DIDYEIQVRD LEYLDASMRV TSTLKCNP.. .......... ..........
Q874G2_SACEX PINWDVEAKH YESLGHYVKK CSYQLINP.. .......... ..........
Q8J0G8_SACEX PINWDVEAKH YESLGHYVKK CSYQLINP.. .......... ..........
Q874G3_SACEX PINWDVEAKH YESLGHYVKK CSYQLINP.. .......... ..........
VATA_CANTR YIDWIIEARD YVQVDEIVKT STTQMINP.. .......... ..........
Q6CL64_KLULA SIEWTLEARD MLLVDSSIRE VTQQLINP.. .......... ..........
Q874G6_KLULA SIEWTLEARD MLLVDSSIRE VTQQLINP.. .......... ..........
Q8J0H3_KLULA SIEWTLEARD MLLVHSSIRE VTQQLINP.. .......... ..........
Q8J0H1_9SACH YFEWTVEARD LSLLGSHVRK ATYQTYAP.. .......... ..........
Q8J0G3_ZYGBI FFEWTIEARD ISLLDENVRA ATYQLRAP.. .......... ..........
Q8J0G4_ZYGBA FFEWTIEARD VXELGAHVRK ATHQVYAP.. .......... ..........
Q8J0G6_9SACH FFEWTIEARD VGALGAHVRK ATHQVYAP.. .......... ..........
Q8J0G5_9SACH FFEWTIEARD VAVLGADVRE ATYQVYSP.. .......... ..........
Q96UY3_9SACH YFEWTIEARD LSLLGSHVRK ATYQTYAP.. .......... ..........
Q2P9Q8_SACPS YFEWTIEARD LSLLGSHVRK ATYQTYAP.. .......... ..........
Q874F9_SACPS YFEWTIEARD LSLLGSHVRK ATYQTYAP.. .......... ..........
Q874H0_YEAST YFEWTIEARD LSLLGSHVRK ATYQTYAP.. .......... ..........
Q874H2_YEAST YFEWTIEARD LSLLGSHVRK ATYQTYAP.. .......... ..........
Q874H1_YEAST YFEWTIEARD LSLLGSHVRK ATYQTYAP.. .......... ..........
Q86Z73_YEAST YFEWTIEARD LSLLGSHVRK ATYQTYAP.. .......... ..........
Q874G9_YEAST YFEWTIEARD LSLLGSHVRK ATYQTYAP.. .......... ..........
Q86Z53_YEAST YFEWTIEARD LSLLGSHVRK ATYQTYAP.. .......... ..........
RGYR_METJA YKYLRNRRVP LKYL.IEWNF DLDEIEKE.. .......... ..........
VATA_YEAST YFEWTIEARD LSLLGSHVRK ATYQTYAP.. .......... ..........
1VDE_A YFEWTIEARD LSLLGSHVRK ATYQTYAP.. .......... ..........
ss_vde SSSSSSSHHH HHH..HHHHH H.SSSS.... .......... ..........
domains .......... .......... .><.SP.>.. .......... ..........
catalyt_resi .......... .......... .......... .......... ..........
cont_type .......... .....BG..H .......... .......... ..........
sidechain .......... ......+..+ .......... .......... ..........
dna_confirm .......... .....++... .......... .......... ..........
mut_<10%_active .......... .......... .......... .......... ..........
2CW8:A GELVEVTGDE L.......KP GDLVAVPRRL ELPERNHVLN LVELLLGTPE
ss_2cw8 .SSSSSS... .......... ..SSSSS... .......SSS HHHHHH...H
1DQ3:A FKIVEKRADE L.......KE GDILIGGMPD GEDYKFI... ..........
ss_1dq3 ..SSSSS... .......... ..SS...... .......... ..........
ss_align ++++++++++ +.......++ +++++++... .......... ..........

251 300
Q8J0G2_ZYGRO .......... .......... .......... .......... ..........
Q8J0H2_9SACH .......... .......... .......... .......... ..........
Q874G1_9SACH .......... .......... .......... .......... ..........
Q8J0G7_9SACH .......... .......... .......... .......... ..........
Q874G4_9SACH .......... .......... .......... .......... ..........
Q8J0G9_9SACH .......... .......... .......... .......... ..........
Q874G5_SACCA .......... .......... .......... .......... ..........
Q8J0H0_SACCA .......... .......... .......... .......... ..........
Q2P9R3_DEBHA .......... .......... .......... .......... ..........
Q6BRM0_DEBHA .......... .......... .......... .......... ..........
HO_YEAST .......... .......... .......... .......... ..........
Q9P986_SACPS .......... .......... .......... .......... ..........
Q8J2S8_SACPA .......... .......... .......... .......... ..........
Q9P984_SACBA .......... .......... .......... .......... ..........
Q9P985_SACPS .......... .......... .......... .......... ..........
Q707W4_KLUDE .......... .......... .......... .......... ..........
Q707W9_CANGA .......... .......... .......... .......... ..........
Q874G2_SACEX .......... .......... .......... .......... ..........
Q8J0G8_SACEX .......... .......... .......... .......... ..........
Q874G3_SACEX .......... .......... .......... .......... ..........
VATA_CANTR .......... .......... .......... .......... ..........
Q6CL64_KLULA .......... .......... .......... .......... ..........
Q874G6_KLULA .......... .......... .......... .......... ..........
Q8J0H3_KLULA .......... .......... .......... .......... ..........
Q8J0H1_9SACH .......... .......... .......... .......... ..........
Q8J0G3_ZYGBI .......... .......... .......... .......... ..........
Q8J0G4_ZYGBA .......... .......... .......... .......... ..........
Q8J0G6_9SACH .......... .......... .......... .......... ..........
Q8J0G5_9SACH .......... .......... .......... .......... ..........
Q96UY3_9SACH .......... .......... .......... .......... ..........
Q2P9Q8_SACPS .......... .......... .......... .......... ..........
Q874F9_SACPS .......... .......... .......... .......... ..........
Q874H0_YEAST .......... .......... .......... .......... ..........
Q874H2_YEAST .......... .......... .......... .......... ..........
Q874H1_YEAST .......... .......... .......... .......... ..........
Q86Z73_YEAST .......... .......... .......... .......... ..........
Q874G9_YEAST .......... .......... .......... .......... ..........
Q86Z53_YEAST .......... .......... .......... .......... ..........
RGYR_METJA .......... .......... .......... .......... ..........
VATA_YEAST .......... .......... .......... .......... ..........
1VDE_A .......... .......... .......... .......... ..........
ss_vde .......... .......... .......... .......... ..........
domains .......... .......... .......... .......... ..........
catalyt_resi .......... .......... .......... .......... ..........
cont_type .......... .......... .......... .......... ..........
sidechain .......... .......... .......... .......... ..........
dna_confirm .......... .......... .......... .......... ..........
mut_<10%_active .......... .......... .......... .......... ..........
2CW8:A EETLDIVMTI PVKGKKNFFK GMLRTLRWIF GEEKRPRTAR RYLRHLEDLG
ss_2cw8 HH....SSSS S......HHH HHHHHHHHH. ........HH HHHHHHHHH.
1DQ3:A .......... .......... .......... .......... ..........
ss_1dq3 .......... .......... .......... .......... ..........
ss_align .......... .......... .......... .......... ..........

301 350
Q8J0G2_ZYGRO .......... .......... .......... .......... ..........
Q8J0H2_9SACH .......... .......... .......... .......... ..........
Q874G1_9SACH .......... .......... .......... .......... ..........
Q8J0G7_9SACH .......... .......... .......... .......... ..........
Q874G4_9SACH .......... .......... .......... .......... ..........
Q8J0G9_9SACH .......... .......... .......... .......... ..........
Q874G5_SACCA .......... .......... .......... .......... ..........
Q8J0H0_SACCA .......... .......... .......... .......... ..........
Q2P9R3_DEBHA .......... .......... .......... .......... ..........
Q6BRM0_DEBHA .......... .......... .......... .......... ..........
HO_YEAST .......... .......... .......... .......... ..........
Q9P986_SACPS .......... .......... .......... .......... ..........
Q8J2S8_SACPA .......... .......... .......... .......... ..........
Q9P984_SACBA .......... .......... .......... .......... ..........
Q9P985_SACPS .......... .......... .......... .......... ..........
Q707W4_KLUDE .......... .......... .......... .......... ..........
Q707W9_CANGA .......... .......... .......... .......... ..........
Q874G2_SACEX .......... .......... .......... .......... ..........
Q8J0G8_SACEX .......... .......... .......... .......... ..........
Q874G3_SACEX .......... .......... .......... .......... ..........
VATA_CANTR .......... .......... .......... .......... ..........
Q6CL64_KLULA .......... .......... .......... .......... ..........
Q874G6_KLULA .......... .......... .......... .......... ..........
Q8J0H3_KLULA .......... .......... .......... .......... ..........
Q8J0H1_9SACH .......... .......... .......... .......... ..........
Q8J0G3_ZYGBI .......... .......... .......... .......... ..........
Q8J0G4_ZYGBA .......... .......... .......... .......... ..........
Q8J0G6_9SACH .......... .......... .......... .......... ..........
Q8J0G5_9SACH .......... .......... .......... .......... ..........
Q96UY3_9SACH .......... .......... .......... .......... ..........
Q2P9Q8_SACPS .......... .......... .......... .......... ..........
Q874F9_SACPS .......... .......... .......... .......... ..........
Q874H0_YEAST .......... .......... .......... .......... ..........
Q874H2_YEAST .......... .......... .......... .......... ..........
Q874H1_YEAST .......... .......... .......... .......... ..........
Q86Z73_YEAST .......... .......... .......... .......... ..........
Q874G9_YEAST .......... .......... .......... .......... ..........
Q86Z53_YEAST .......... .......... .......... .......... ..........
RGYR_METJA .......... .......... .......... .......... ..........
VATA_YEAST .......... .......... .......... .......... ..........
1VDE_A .......... .......... .......... .......... ..........
ss_vde .......... .......... .......... .......... ..........
domains .......... .......... .......... .......... ..........
catalyt_resi .......... .......... .......... .......... ..........
cont_type .......... .......... .......... .......... ..........
sidechain .......... .......... .......... .......... ..........
dna_confirm .......... .......... .......... .......... ..........
mut_<10%_active .......... .......... .......... .......... ..........
2CW8:A YVRLKKIGYE VLDWDSLKNY RRLYEALVEN VRYNGNKREY LVEFNSIRDA
ss_2cw8 .SSS....SS S..HHHHHHH HHHHHHHHHH .SS.....SS S..HHHHHHH
1DQ3:A .......... .......... .......... .......... ..........
ss_1dq3 .......... .......... .......... .......... ..........
ss_align .......... .......... .......... .......... ..........

351 400
Q8J0G2_ZYGRO .....VLLEN NHFSHYLKDS NSAVGNDTVR ALSYFLGLWI GDGMLNN...
Q8J0H2_9SACH .....VLYEC ENLLQYLKNT KYNLNEKSPT ALAYLLGLWT GSGMTR....
Q874G1_9SACH .....VFYES GKLASR..LQ TKNIDQTSAD KLAYVMGSWV GAGSMD....
Q8J0G7_9SACH .....VFYES GKLASR..LQ TKNIDQTSAD KLAYVMGSWV GAGSMD....
Q874G4_9SACH .....VFKES GNLIAK..LN ELGFSKEIAP QMGWLLGFWV GNGSIT....
Q8J0G9_9SACH .....VFKES GNLIAK..LN ELGFSKEIAP QMGWLLGFWV GNGSIT....
Q874G5_SACCA .....VFKES GNLANI..LG DAGIEKTLAA KMAWLLGFWV GNGHME....
Q8J0H0_SACCA .....VFKES GNLANI..LG DAGIEKTLAA KMAWLLGFWV GNGHME....
Q2P9R3_DEBHA .....VLASK EVLAPV..VQ EAGFDATIAP YVSYLLGLWI GNGYSD....
Q6BRM0_DEBHA .....VLASK EVLAPV..VQ EAGFDATIAP YVSYLLGLWI GNGYSD....
HO_YEAST .....VLAGN GVLSKFL.TG RSDLVTPAVK SMAWMLGLWL GDSTTK....
Q9P986_SACPS .....VLAGN GVLSKFL.TG RSDLVTPAVK SMAWMLGLWL GDDTTK....
Q8J2S8_SACPA .....VLTGN GVLSKFL.TG RSDLVTPAVK SMAWMLGLWL GDGTTK....
Q9P984_SACBA .....VIAGN GVLSKFL.TG RNDLVTPAVK SMAWMLGLWL GDGTTK....
Q9P985_SACPS .....VIAGN GVLSKFL.TG RNDLVTPAVK SMAWMLGLWL GDGTTK....
Q707W4_KLUDE .....ILCGN GILSKFL.SG KPHLITPSIT AMAWLLGLWI GDGTTK....
Q707W9_CANGA .....VFSGN GILSNFL.SG QRHLITPAIV SMAWLLGLWI GDGTTK....
Q874G2_SACEX .....VFHQS GKLAQE..IA SLNYSKDKAP LLAWLIGFWV GNGAMR....
Q8J0G8_SACEX .....VFHQS GKLAQE..IA SLNYSKDKAP LLAWLIGFWV GNGAMR....
Q874G3_SACEX .....VFHQS GKLAQE..IA SLNYSKDKAP LLAWLIGFWV GNGAMR....
VATA_CANTR .....VHFES GKLGNW..LH EHKQNKSLAP QLGYLLGTWA GIGNVK....
Q6CL64_KLULA .....VLLEK EHLAGV..LK SNDFQSSLAP QFSYLLGAFV GSSGK.....
Q874G6_KLULA .....VLLEK EHLAGV..LK SNDFQSSLAP QFSYLLGAFV GSSGK.....
Q8J0H3_KLULA .....VLLEK EHLAGV..LK SNDFQSSLAP QFSYLLGAFV GSSGK.....
Q8J0H1_9SACH .....ILYEN DYFFNYMENS KFHPTIEAPK VLAYFLGLWI GDGLTD....
Q8J0G3_ZYGBI .....VLLQN DFFSQYVSNS KFASGTEATR ALSYFLGLWI GGGLTD....
Q8J0G4_ZYGBA .....VLYES DFFFHYVKNS KFALRSEAST ALAYLLGLWV GDGLSD....
Q8J0G6_9SACH .....VLYES DFFFHYVKDS KFCLKSEAPF ALAYLLGLWV GDGLSD....
Q8J0G5_9SACH .....VLYES DFFSQYVKDS KFGLTSEAPL ALAYLLGLWA GDVSSE....
Q96UY3_9SACH .....ILYEN DHFFDYMQKS KFHLTIEGPK VLAYLLGLWI GDGLSD....
Q2P9Q8_SACPS .....ILYEN DHFFDYMQKS KFHLTIEGPK VLAYLLGLWI GDGLSD....
Q874F9_SACPS .....ILYEN DHFFDYMQKS KFHLTIEGPK VLAYLLGLWI GDGLSD....
Q874H0_YEAST .....ILYEN DHFFDYMQKS KFHLTIEGPK VLAYLLGLWI GDGLSD....
Q874H2_YEAST .....ILYEN DHFFDYMQKS KFHLTIEGPK VLAYLLGLWI GDGLSD....
Q874H1_YEAST .....ILYEN DHFFDYMQKS KFHLTIEGPK VLAYLLGLWI GDGLSD....
Q86Z73_YEAST .....ILYEN DHFFDYMQKS KFHLTIEGPK VLAYLLGLWI GDGLSD....
Q874G9_YEAST .....ILYEN DHFFDYMQKS KFHLTIEGPK VLAYLLGLWI GDGLSD....
Q86Z53_YEAST .....ILYEN DHFFDYMQKS KFHLTIEGPK VLAYLLGLWI GDGLSD....
RGYR_METJA .....AKYIY KSVAGTKKIP LFKLD....E RFWYFAGLVL GDGSIQD...
VATA_YEAST .....ILYEN DHFFDYMQKS KFHLTIEGPK VLAYLLGLWI GDGLSD....
1VDE_A .....ILYEN DHFFDYMQKS KFHLTIEGPK VLAYLLGLWI GDGLSD....
ss_vde .......... .HHHHHHHH. .......HHH HHHHHHHHHH HH........
domains .....<.... .......... .......... ..FIRST.LA GLIDADG...
catalyt_resi .......... .......... .......... .......... .+........
cont_type .......... .......... .......... .......... ...H......
sidechain .......... .......... .......... .......... ...+......
dna_confirm .......... .......... .......... .......... ..........
mut_<10%_active .......... .......... .......... .......... .+........
2CW8:A VGIMPLKELK EWKIGTLNGF RMRKLIEVDE SLAKLLGYYV SEGYARKQRN
ss_2cw8 H....HHHH. ..SSS..... SSS.SSS..H HHHHHHHHHH HHSSSSSS..
1DQ3:A .......... .......... .......... FDYWLAGFIA GDGCFDKYHS
ss_1dq3 .......... .......... .......... HHHHHHHHHH HHSSSSSSS.
ss_align .......... .......... .......... .......... ..........

401 450
Q8J0G2_ZYGRO .......... AATFSVDSQN ASLLNRINEF AEVLGLSAEY KDSQEPKRAK
Q8J0H2_9SACH .......... RAGLSVSTTD ESLMNNIVAA ADLLNLKSEF KQERTTTRVG
Q874G1_9SACH .......... QPTFAGNQLD EEFVSRLTEY GSGLDLTK.. ..........
Q8J0G7_9SACH .......... QPTFAGNQLD EEFVSRLTEY GSGLDLTK.. ..........
Q874G4_9SACH .......... TSSFSIDSLD TQLLDRITEY GKLFALTTTS ATNHCRNYSG
Q8J0G9_9SACH .......... TSSFSIDSLD TQLLDRITEY GKLFALTTTS ATNHCRNYSG
Q874G5_SACCA .......... TAQFPVDSWD TQLVDRISEY GKHFNLTTTT ENHYRSNHVE
Q8J0H0_SACCA .......... TAQFPVDSWD TQLVDRISEY GKHFNLTTTT ENHYRSNHVE
Q2P9R3_DEBHA .......... RVQYLIDGKN TELINRVREY DEAIENNNQ. ..........
Q6BRM0_DEBHA .......... RVQYLIDGKN TELINRVREY DEAIENNNQ. ..........
HO_YEAST .......... EPEISVDSLD PKLMESLREN AKIWGLYLTV CDDHVPLRAK
Q9P986_SACPS .......... EPEISVDSLD PKLMESLREN AKIWGLYLTV CDDHVPLRAK
Q8J2S8_SACPA .......... EPEISVDSLD PKLMESLRKH AKIWGLYLTV CDDHAPLRAK
Q9P984_SACBA .......... EPEISVDSLD PKLMESLREQ AKIWGLYLTV CDDHVPLRAK
Q9P985_SACPS .......... EPEISVDSLD PKLMESLREQ AKIWGLYLTV CDDHVPLRAK
Q707W4_KLUDE .......... EPEITMDSLD APLMNSLIVL GRKWGIYPTY KDEKVPLRAK
Q707W9_CANGA .......... EPEITVDSVD EKLMESLTVL GRYWGLYPTY KDEKVPLRAK
Q874G2_SACEX .......... HSQFVIDSQD IELVNRIQEI ATLLNLSATT ACYYSGSVDD
Q8J0G8_SACEX .......... HSQFVIDSQD IELVNRIQEI ATLLNLSATT ACYYSGSVDD
Q874G3_SACEX .......... HSQFVVESQD IELVNRIQDI AGLLNLSATT ACYYSGSKDD
VATA_CANTR .......... SSAFTMNSKD DVKLATRIMN YSSKLGMTCS STESGELNVA
Q6CL64_KLULA .......... .DNSEYLQQL SAQFDKKIVA EKSIDVQSNG KTVGTASIVI
Q874G6_KLULA .......... .DNSEYLQQL SAQFDKKIVA EKSIDVQSNG KTVGTASIVI
Q8J0H3_KLULA .......... .DNSKYLQQL SAQFDKKIVA EKSIDVQSNG KTVGTASIVI
Q8J0H1_9SACH .......... RTTFSIDSRD TSLMERVTEY AEKLDLCAEY KDRKEPKVAK
Q8J0G3_ZYGBI .......... KTTLSVDSED TSLFDRINQF AEILGLSAEQ EAKEESKRAK
Q8J0G4_ZYGBA .......... RAVLSVDSED SSLLERITGY ADILDLSAEY KDREIPKRAK
Q8J0G6_9SACH .......... RAVFSVDSED TTLFDRIIDF ADILDLSAEY KDREIPKRAK
Q8J0G5_9SACH .......... ETVFSVNSED GSLYERITQF ADILGLSAEF KDREAPKQGK
Q96UY3_9SACH .......... RATFSVDSRD TSLMERVTEY AEKLNLCAEY KDRKEPQVAK
Q2P9Q8_SACPS .......... RATFSVDSRD TSLMERVTEY AEKLNLCAEY KDRKEPQVAK
Q874F9_SACPS .......... RATFSVDSRD TSLMERVTEY AEKLNLCAEY KDRKEPQVAK
Q874H0_YEAST .......... RATFSVDSRD TSLMERVTEY AEKLNLCAEY KDRKEPQVAK
Q874H2_YEAST .......... RATFSVDSRD TSLMERVTEY AEKLNLCAEY KDRKEPQVAK
Q874H1_YEAST .......... RATFSVDSRD TSLMERVTEY AEKLNLCAEY KDRKEPQVAK
Q86Z73_YEAST .......... RATFSVDSRD TSLMERVTEY AEKLNLCAEY KDRKEPQVAK
Q874G9_YEAST .......... RATFSVDSRD TSLMERVTEY AEKLNLCAEY KDRKEPQVAK
Q86Z53_YEAST .......... RATFSVDSRD TSLMERVTEY AEKLNLCAEY KDRKEPQVAK
RGYR_METJA .......... SKIRIAQTPL KDVKSILDET FPF..LHNWI SGN...QVII
VATA_YEAST .......... RATFSVDSRD TSLMERVTEY AEKLNLCAEY KDRKEPQVAK
1VDE_A .......... RATFSVDSRD TSLMERVTEY AEKLNLCAEY KDRKEPQVAK
ss_vde .......... ..SSSSS... HHHHHHHHHH HHH..SSSSS SS......SS
domains .......... .......... .......... .......... ..........
catalyt_resi .......... ......W... .......... .......... ..........
cont_type .......... J...B..... .......... .......... ........B.
sidechain .......... +...+..... .......... .......... ..........
dna_confirm .......... .......... .......... .......... ..........
mut_<10%_active .......... ......+.++ .......... .......... ..........
2CW8:A PK...NGWSY SVKLYNE..D PEVLDDMERL ASRFFGKVRR GR.......N
ss_2cw8 ........SS SSSSS..... HHHHHHHHHH HHHHH...SS ..........
1DQ3:A HVKGHEYIYD RLRIYDY..R IETFEIINDY LEKTFGRKYS IQKDR..NIY
ss_1dq3 .......SSS SSSSSS.... HHHHHHHHHH HHHHH..... .SS......S
ss_align .......... .......... .......... .......... ..........

451 500
Q8J0G2_ZYGRO TVNLYAKAIR DEGV...... .......... .......... ..........
Q8J0H2_9SACH NVNFYGNST. .......... .......... .......... ..........
Q874G1_9SACH .......... .......... .......... .......... ..........
Q8J0G7_9SACH .......... .......... .......... .......... ..........
Q874G4_9SACH SGNQDIELSK INNGKVET.. .DGTITFDDD TEREPSEQEL IDMES.....
Q8J0G9_9SACH SGNQDIELSK INNGKVET.. .DGTITFDDD TEREPSEQEL IDMES.....
Q874G5_SACCA S.NKDIEIFE MNEAQIEEAE QTGVVAFDSN RKGDPSETEL IEAEIFNESR
Q8J0H0_SACCA S.NKDIEIFE MNEAQIEEAE QTGVVAFDSN RKGDPSETEL IEAEIFNESR
Q2P9R3_DEBHA .......... .......... .......... .......... ..........
Q6BRM0_DEBHA .......... .......... .......... .......... ..........
HO_YEAST HVRLHYGDGP DENRK..... .......... .......... ..........
Q9P986_SACPS HVRLHYGDGP DENRK..... .......... .......... ..........
Q8J2S8_SACPA HVRLHYGDGP GENRK..... .......... .......... ..........
Q9P984_SACBA HVRLHYGDGP DENRK..... .......... .......... ..........
Q9P985_SACPS HVRLHYGDGP DENRK..... .......... .......... ..........
Q707W4_KLUDE HVRLYYGNEP EEKRK..... .......... .......... ..........
Q707W9_CANGA HVRLYYGKGP EERRK..... .......... .......... ..........
Q874G2_SACEX QDKLAKLNTA TGEGFEDDLQ SNPTAKELAD MDILSESKTA TLPTAFGVEK
Q8J0G8_SACEX QDKLAKLNTA TGEGFEDDLQ SNPTAKELAD MDILSESKTA TLPTAFGVEK
Q874G3_SACEX EAKLAKLNSS SAEGFEDDLE GNPSVKELAD MDRLSESKTA TLPTAFGVEN
VATA_CANTR ENEEEFFNNL GAEKDEAGDF TFDEFTDAMD ELTINVHG.. ..........
Q6CL64_KLULA S......... .......... .......... .......... ..........
Q874G6_KLULA S......... .......... .......... .......... ..........
Q8J0H3_KLULA S......... .......... .......... .......... ..........
Q8J0H1_9SACH TVNLYSKSVR XNGI...... .......... .......... ..........
Q8J0G3_ZYGBI KVNLHPKTNG AEDA...... .......... .......... ..........
Q8J0G4_ZYGBA TVCLYPKTIR GNDI...... .......... .......... ..........
Q8J0G6_9SACH TVGLFPKTIR GNDI...... .......... .......... ..........
Q8J0G5_9SACH TVYLHPKAIG GNDI...... .......... .......... ..........
Q96UY3_9SACH TVNLYSKVVR GNGV...... .......... .......... ..........
Q2P9Q8_SACPS TVNLYSKVVR GNGV...... .......... .......... ..........
Q874F9_SACPS TVNLYSKVVR GNGV...... .......... .......... ..........
Q874H0_YEAST TVNLYSKVVR GNGV...... .......... .......... ..........
Q874H2_YEAST TVNLYSKVVR GNGI...... .......... .......... ..........
Q874H1_YEAST TVNLYSKVVR GNGI...... .......... .......... ..........
Q86Z73_YEAST TVNLYSKVVR GNGV...... .......... .......... ..........
Q874G9_YEAST TVNLYSKVVR GNGI...... .......... .......... ..........
Q86Z53_YEAST TVNLYSKVVR GNGI...... .......... .......... ..........
RGYR_METJA SNPIIAEILE KL........ .......... .......... ..........
VATA_YEAST TVNLYSKVVR GNGI...... .......... .......... ..........
1VDE_A TVNLYSKVVR GNGI...... .......... .......... ..........
ss_vde SSSSSS.... .......... .......... .......... ..........
domains .......... .......... .......... .......... ..........
catalyt_resi .......... .......... .......... .......... ..........
cont_type ....B..... .BB....... .......... .......... ..........
sidechain ....+..... .......... .......... .......... ..........
dna_confirm .......... .......... .......... .......... ..........
mut_<10%_active .......... .......... .......... .......... ..........
2CW8:A YVEIP..... .......... .......... .......... ..........
ss_2cw8 SSSS...... .......... .......... .......... ..........
1DQ3:A YIDIK..... .......... .......... .......... ..........
ss_1dq3 SSSS...... .......... .......... .......... ..........
ss_align .......... .......... .......... .......... ..........

501 550
Q8J0G2_ZYGRO .......... .......... .......... .....RKNLD THNLLWDAIV
Q8J0H2_9SACH .......... .......... .......... .....STNQN VDNLLWDAIQ
Q874G1_9SACH .......... .......... .......... .......... .NNSVWDIIN
Q8J0G7_9SACH .......... .......... .......... .......... .NNSVWDIIN
Q874G4_9SACH .......... ..SGCKASSE MTVALGAPLV RGNAIRQLLT ENNVFLKLIE
Q8J0G9_9SACH .......... ..SGCKASSE MTVALGAPLV RGNAIRQLLT ENNVFLKLIE
Q874G5_SACCA PSTAGLFTPA AISPASLVTD LSVTLRGTGI GGAGVSKERN LNNIFWDIVT
Q8J0H0_SACCA PSTAGLFTPA AISPASLVTD LSVTLRGTGI GGAGVSKERN LNNIFWDIVT
Q2P9R3_DEBHA .......... .......... .......... ......TSAK TVDFLWDVIN
Q6BRM0_DEBHA .......... .......... .......... ......TSAK TVDFLWDVIN
HO_YEAST .......... .......... .......... .....TRNLR KNNPFWKAVT
Q9P986_SACPS .......... .......... .......... .....TRNLR KNNPFWKAVT
Q8J2S8_SACPA .......... .......... .......... .....TRNLR KNNPFWKAVT
Q9P984_SACBA .......... .......... .......... .....TKNLR KNNPFWNAVT
Q9P985_SACPS .......... .......... .......... .....TKNLR KNNPFWNAVT
Q707W4_KLUDE .......... .......... .......... .....TRNLR KNNPFWNTVL
Q707W9_CANGA .......... .......... .......... .....TRNLR KNNPFWNTIQ
Q874G2_SACEX IDELIISL.. .......... .......... .....GEGRG NGNVFAQVIG
Q8J0G8_SACEX IDELIISL.. .......... .......... .....GEGRG NGNVFAQVIG
Q874G3_SACEX IDELIISL.. .......... .......... .....GEGRG NGNVFAQVIG
VATA_CANTR .......... .......... .......... .....AAASK KNNLLWNALK
Q6CL64_KLULA .......... .......... .......... .....QEPVQ ENKRRKVAQV
Q874G6_KLULA .......... .......... .......... .....QEPVQ ENKRRKVAQV
Q8J0H3_KLULA .......... .......... .......... .....QEPVQ ENKRRKVAQV
Q8J0H1_9SACH .......... .......... .......... .....RNNLN TENPLWDAIV
Q8J0G3_ZYGBI .......... .......... .......... .....DRSLN IGNPLWNAIV
Q8J0G4_ZYGBA .......... .......... .......... .....RRNLN TDNPVWNAIV
Q8J0G6_9SACH .......... .......... .......... .....GRNLN TDNPLWNAIV
Q8J0G5_9SACH .......... .......... .......... .....QENSN NDNPLRNAIV
Q96UY3_9SACH .......... .......... .......... .....RNNLN TENPLWDAII
Q2P9Q8_SACPS .......... .......... .......... .....RNNLN TENPLWDAII
Q874F9_SACPS .......... .......... .......... .....RNNLN TENPLWDAII
Q874H0_YEAST .......... .......... .......... .....RNNLN TENPLWDAII
Q874H2_YEAST .......... .......... .......... .....PNNLN TENPLWDAIV
Q874H1_YEAST .......... .......... .......... .....RNNLN TENPLWDAIV
Q86Z73_YEAST .......... .......... .......... .....RNNLN TENPLWDAII
Q874G9_YEAST .......... .......... .......... .....RNNLN TENPLWDAIV
Q86Z53_YEAST .......... .......... .......... .....RNNLN TENPLWDAIV
RGYR_METJA .......... .......... .......... .......... ..........
VATA_YEAST .......... .......... .......... .....RNNLN TENPLWDAIV
1VDE_A .......... .......... .......... .....RNNLN TENPLWDAIV
ss_vde .......... .......... .......... .......... ...HHHHHHH
domains .......... .......... .......... .......... ..........
catalyt_resi .......... .......... .......... .......... ..........
cont_type .......... .......... .......... .....BB.BB B.........
sidechain .......... .......... .......... .....+...+ +.........
dna_confirm .......... .......... .......... .......... ..........
mut_<10%_active .......... .......... .......... .....+.+.+ +.+.......
2CW8:A .......... .......... .......... ......KKIG YLLFENMCGV
ss_2cw8 .......... .......... .......... .......HHH HHHHHHHH..
1DQ3:A .......... .......... .......... ......ARNI TSHYLKLLEG
ss_1dq3 .......... .......... .......... .......HHH HHHHHHHH..
ss_align .......... .......... .......... .......... ..........

551 600
Q8J0G2_ZYGRO DLGYLK.... .DDSKNVPGY ICSDSFQHRE VFLAGIIDST GYVSDE....
Q8J0H2_9SACH ELGFIQ.... .DGNKTVPSF LSSDLIEIRE TFLAGLIDSN GSVDNNKQDI
Q874G1_9SACH ESGLRTLNAN GEATKTIPKE LVSDSISVRE HFIAGLVDTQ GNVKRASTGA
Q8J0G7_9SACH ESGLRTLNAN GEATKTIPKE LVSDSISVRE HFIAGLVDTQ GNVKRASTGA
Q874G4_9SACH SFGVRKENGS .EYVKAIPMH LSYDDIEVRE QFIAGLVDSI GHVKRTSNGT
Q8J0G9_9SACH SFGVRKENGS .EYVKAIPMH LSYDDIEVRE QFIAGLVDSI GHVKRTSNGT
Q874G5_SACCA SFGVRTNGQG STYEKSVPLH LSYDDIEVRE QFIAGLIDSD GYVKSADNRF
Q8J0H0_SACCA SFGVRTNGQG STYEKSVPLH LSYDDIEVRE QFIAGLIDSD GYVKSADNRF
Q2P9R3_DEBHA SMSFKVEG.. .KSGKAIPSF LRTESFEVRE QFLAGLIDSD GIVTKNPL..
Q6BRM0_DEBHA SMSFKVEG.. .KSGKAIPSF LRTESFEVRE QFLAGLIDSD GIVTKNPL..
HO_YEAST ILKFKRDL.. .DGEKQIPEF MYGEHIEVRE AFLAGLIDSD GYVVKKGEGP
Q9P986_SACPS ILKFKRDL.. .DGEKQIPEF MYGEHIEVRE AFLAGLIDSD GYVVKKGEGP
Q8J2S8_SACPA ILKFKRDL.. .DGEKQIPEF MYGEHIEVRE AFLAGLIDSD GYVVKKGEGP
Q9P984_SACBA KLKFKREL.. .DGEKQIPEF MYSEHVEVRE AFLAGLIDSD GYVVKKGEGP
Q9P985_SACPS KLKFKREL.. .DGEKQIPEF MYSEHVEVRE AFLAGLIDSD GYVVKKGEGP
Q707W4_KLUDE ALGFKKEN.. .SGEKYVPEF MWTEDIEIRE AFLAGLIDSD GYVSKRKDNP
Q707W9_CANGA NLGIKREI.. .DGEKQVPEF MWHEDIEIRE AFLAGLIDSD GYVVKRKENP
Q874G2_SACEX SFGIDLADKD .TLVSKIAHE LAGDAFEVRE QFVAGLVDAT GYVRKDVYDH
Q8J0G8_SACEX SFGIDLADKD .TLVSKIAHE LAGDAFEVRE QFVAGLVDAT GYVRKDVYDH
Q874G3_SACEX SFGIDLADKD .TLVTKIAHE LAGDAFEVRE QFVAGLVDAA GYVRKDVYDH
VATA_CANTR SLGFRAKST. .DIVKSIPQH IAVDDIVVRE SLIAGLVDAA GNVETKSNGS
Q6CL64_KLULA SLVSKIVQE. .SFSSGIPSF MMSENINVRE SFLAGIVDSQ NQKLDD....
Q874G6_KLULA SLVSKIVQE. .SFSSGIPSF MMSENINVRE SFLAGIVDSQ NQKLDD....
Q8J0H3_KLULA SLVSKIVQE. .SFSSGIPSF MMSENINVRE SFLAGIVDSQ NQKLDD....
Q8J0H1_9SACH GLGFLK.... .DGVKNIPSF LSTDNIGTRE TFLAGLIDSD GYVTDEHG..
Q8J0G3_ZYGBI DLEYLK.... .DGSKNVPAY LSSDCFENRE MFLAGLVDSE GHVRGEV...
Q8J0G4_ZYGBA DLGYLK.... .DGVKNVPSY LFSDSICHRE VFLAGLIDSD GHVRGDDG..
Q8J0G6_9SACH DLGYLK.... .GGVKHVPSY LLTDSIPHRE VFLAGLIDSD GYVRGEEA..
Q8J0G5_9SACH DLGYLT.... .DGVKNVPTY LLSDAIPHRE IFLAGLIDSD GFVRSEDG..
Q96UY3_9SACH GLGFLK.... .DGVKNIPSF LSTDNIGTRE TFLAGLIDSD GYVTDEHG..
Q2P9Q8_SACPS GLGFLK.... .DGVKNIPSF LSTDNIGTRE TFLAGLIDSD GYVTDEHG..
Q874F9_SACPS GLGFLK.... .DGVKNIPSF LSTDNIGTRE TFLAGLIDSD GYVTDEHG..
Q874H0_YEAST GLGFLK.... .DGVKNIPSF LSTDNIGTRE TFLAGLIDSD GYVTDEHG..
Q874H2_YEAST GLGFLK.... .DGVKNIPSF LSTDNIGTRE TFLAGLIDSD GYVTDEHG..
Q874H1_YEAST GLGFLK.... .DGVKNIPSF LSTDNIGTRE TFLAGLIDSD GYVTDEHG..
Q86Z73_YEAST GLGFLK.... .DGVKNIPSF LSTDNIGTRE TFLAGLIDSD GYVTDEHG..
Q874G9_YEAST GLGFLK.... .DGVKNIPSF LSTDNIGTRE TFLAGLIDSD GYVTDEHG..
Q86Z53_YEAST GLGFLK.... .DGVKNIPSF LSTDNIGTRE TFLAGLIDSD GYVTDEHG..
RGYR_METJA GMRNGKL... ....NGI.IF SLP..ESYIN ALIAGYFDTD GCFSLLYD..
VATA_YEAST GLGFLK.... .DGVKNIPSF LSTDNIGTRE TFLAGLIDSD GYVTDEHG..
1VDE_A GLGFLK.... .DGVKNIPSF LSTDNIGTRE TFLAGLIDSD GYVTDEHG..
ss_vde H......... ........HH HHH..HHHHH HHHHHHHHHH SSSS......
domains .....>.... .<......SE COND.LAGLI DADG...... ..........
catalyt_resi .......... ....W..... .......... .........+ ..........
cont_type .......... .......... .......... .......... .P........
sidechain .......... .......... .......... .......... .+........
dna_confirm .......... .......... .......... .......... ..........
mut_<10%_active .......... ....+..... .......... .........+ .+........
2CW8:A .......... LAENKRIPEF VFTSPKGVRL AFLEGYFIGD GDVHPN....
ss_2cw8 .......... .HHH....HH H....HHHHH HHHHHHHHHH ..........
1DQ3:A .......... .IDN.GIPPQ ILKEGKNAVL SFIAGLFDAE GHVSN.....
ss_1dq3 .......... .HHH....HH HH...HHHHH HHHHHHHHHH .SSS......
ss_align .......... .......... .......... .......... ..........

601 650
Q8J0G2_ZYGRO ...TATVKTI DQSVMTGTVA VARSLGI.NV SVDVEVD... .........E
Q8J0H2_9SACH ...SCTIELE DNKVMSGIVS LIRSLGL.KA DVTQSSG... ........KL
Q874G1_9SACH VE.TASISTV YERISNDLVK LARSLGI.KA SVSQQEE... ........HV
Q8J0G7_9SACH VE.TASISTV YERISNDLVK LARSLGI.KA SVSQQEE... ........HV
Q874G4_9SACH IE.CAAISTA YKSVSEGLIR LARSLGI.KV SVTTKRE... ........CL
Q8J0G9_9SACH IE.CAAISTA YKSVSEGLIR LARSLGI.KV SVTTKRE... ........CL
Q874G5_SACCA ...SATVTTI YKGVSEGLIR LARSLGI.RV SVSTEKE... ........HV
Q8J0H0_SACCA ...SATVTTI YKGVSEGLIR LARSLGI.RV SVSTEKE... ........HV
Q2P9R3_DEBHA ...SASVRTN SSKVGEGVIA VSRSLGI.CT SVKAE..... ..........
Q6BRM0_DEBHA ...SASVRTN SSKVGEGVIA VSRSLGI.CT SVKAE..... ..........
HO_YEAST ESYKIAIQTV YSSIMDGIVH ISRSLGM.SA TVTTRSAREE ........II
Q9P986_SACPS ESYKIAIQTV YSSIMDGIVH ISRSLGM.SA TVTTRSAREE ........II
Q8J2S8_SACPA ESYKIAIQTV YSSIMDGIVH ISRSLGM.SA TVTTRSAREE ........II
Q9P984_SACBA ESYKIAIQTV YSSIMDGVVH ISRSLGM.SA TVTTRSAREE ........II
Q9P985_SACPS ESYKIAIQTV YSSIMDGVVH ISRSLGM.SA TVTTRSAREE ........II
Q707W4_KLUDE DVYKVSIQTI YPCIMDAVVH IARSLGI.SA TVTTRSARPE ........VI
Q707W9_CANGA DVYKVSIQTI YPSVMNAIVH IARSLGI.SA TVTTRSARNE ........VI
Q874G2_SACEX AS.EATVSIE SKSTVLGLVK IARSLGI.KI VVTSNDYQDP EDHDHGHDHG
Q8J0G8_SACEX AS.EATVSIE SKSTVLGLVK IARSLGI.KI VVTSNDYQDP EDHDHGHDHG
Q874G3_SACEX AS.EATISTE SKSTVLGLVK IARSLGI.KI TVTSDDSDDS DEHDH...AH
VATA_CANTR ..IEAVVRTS FRHVARGLVK IAHSLGI.ES SINIKDT... ........HI
Q6CL64_KLULA ...TVALKTL SVKTHDGIAR LARSLGI.RV SGKKQNQ... ..........
Q874G6_KLULA ...TVALKTL SVKTHDGIAR LARSLGI.RV SGKKQNQ... ..........
Q8J0H3_KLULA ...TVALKTL SVKTHDGIAR LARSLGI.RV SGKKQNQ... ..........
Q8J0H1_9SACH ..ITATVKTI HTSVRDGLVS VARSLGL.VI SVNAEPA... ........KI
Q8J0G3_ZYGBI ....ATINTC HHSVMTGVVA VARSLGI.TV TVNTKGE... ........KF
Q8J0G4_ZYGBA ..LSVTIKTI HKTVMEGTVA VARSLGL.IV SVNTEEA... ........KI
Q8J0G6_9SACH ..PAATIKTI HKTVMEGTVA VARSLGL.TV SVNIEEA... ........KV
Q8J0G5_9SACH ..CSATIKTT LKTVMAGTVA VARSLGL.NV SVNTEEA... ........KV
Q96UY3_9SACH ..IKATIKTI HTSVRDGLVS LARSLGL.VA SVNAEPA... ........KV
Q2P9Q8_SACPS ..IKATIKTI HTSVRDGLVS LARSLGL.VA SVNAEPA... ........KV
Q874F9_SACPS ..IKATIKTI HTSVRDGLVS LARSLGL.VA SVNAEPA... ........KV
Q874H0_YEAST ..IKATIKTI HTSVRDGLVS LARSLGL.VA SVNAEPA... ........KV
Q874H2_YEAST ..IKATIKTI HTSVRDGLVS LARSLGL.VV SVNAEPA... ........KV
Q874H1_YEAST ..IKATIKTI HTSVRDGLVS LARSLGL.VV SVNAEPA... ........KV
Q86Z73_YEAST ..IKATIKTI HTSVRDGLVS LARSLGL.VA SVNAEPA... ........KV
Q874G9_YEAST ..IKATIKTI HTSVRDGLVS LARSLGL.VV SVNAEPA... ........KV
Q86Z53_YEAST ..IKATIKTI HTSVRDGLVS LARSLGL.VV SVNAEPA... ........KV
RGYR_METJA ..KKAKKHNL RMVLTSKRRD VLEKIGI.YL NSIGILNTLH KSREVYSLII
VATA_YEAST ..IKATIKTI HTSVRDGLVS LARSLGL.VV SVNAEPA... ........KV
1VDE_A ..IKATIKTI HTSVRDGLVS LARSLGL.VV SVNAEPA... ........KV
ss_vde ...SSSSSS. .HHHHHHHHH HHHH....SS SSSSS..... ..........
domains .......... .......... .......... .......... ..........
catalyt_resi ........W. .......... .......... .......... ..........
cont_type .......G.. .......... .......... B.H.G..... ..........
sidechain .......+.. .......... .......... +.+.+..... ..........
dna_confirm .......+.. .......... .......... +...+..... ..........
mut_<10%_active .......++. .......... .......... .......... ..........
2CW8:A ..KRLRLSTK SELLANQLVL LLNSVGVSAV KLGHDS.... ..........
ss_2cw8 ....SSSSS. .HHHHHHHHH HHHH.....S SSSS...... ..........
1DQ3:A .KPGIELGMV NKRLIEDVTH YLNALGIKAR IREKLRK... ..........
ss_1dq3 ...SSSSSS. .HHHHHHHHH HHHH.....S SSSSS..... ..........
ss_align .......... .......... .......... .......... ..........

651 700
Q8J0G2_ZYGRO D..GVDRSFV YAIYMDR... .......... .......... ..........
Q8J0H2_9SACH N......DVC YNVTVKG... .......... .......... ..........
Q874G1_9SACH DAKGVDQQQT YNIKLTG... .......... .......... ..........
Q8J0G7_9SACH DAKGVDQQQT YNIKLTG... .......... .......... ..........
Q874G4_9SACH DKHNVKHQIC YSICLSG... .......... .......... ..........
Q8J0G9_9SACH DKHNVKHQIC YSICLSG... .......... .......... ..........
Q874G5_SACCA DKNNVKHKSC YRVFLSG... .......... .......... ..........
Q8J0H0_SACCA DKNNVKHKSC YRVFLSG... .......... .......... ..........
Q2P9R3_DEBHA .......NES YIISMTR... .......... .......... ..........
Q6BRM0_DEBHA .......NES YIISMTR... .......... .......... ..........
HO_YEAST EGRKVQCQFT YDCNVAG... .......... .......... ..........
Q9P986_SACPS EGRKVQCQFT CDCNVAG... .......... .......... ..........
Q8J2S8_SACPA EGRKVQCQFT YDCNVAG... .......... .......... ..........
Q9P984_SACBA EGRKVQCQFT YDCNVAG... .......... .......... ..........
Q9P985_SACPS EGRKVQCQFT YDCNVAG... .......... .......... ..........
Q707W4_KLUDE EGRLVNCQFT YDCNISG... .......... .......... ..........
Q707W9_CANGA EGRRVQCRFT YDCNISG... .......... .......... ..........
Q874G2_SACEX SCGHDEVATG YTAVMTG... .......... .......... ..........
Q8J0G8_SACEX SCGHDEVATG YTAVMTG... .......... .......... ..........
Q874G3_SACEX CGHDHGSSSS YTAVMTG... .......... .......... ..........
VATA_CANTR DAAGVRQEFA CIVNLTG... .......... .......... ..........
Q6CL64_KLULA .........E YTLTLSG... .......... .......... ..........
Q874G6_KLULA .........E YTLTLSG... .......... .......... ..........
Q8J0H3_KLULA .........E YTLTLSG... .......... .......... ..........
Q8J0H1_9SACH DMSGTSHKMC YAIYMSG... .......... .......... ..........
Q8J0G3_ZYGBI GNIGANQDSG YVIQLSS... .......... .......... ..........
Q8J0G4_ZYGBA DKNDVNHRFV YAIYISG... .......... .......... ..........
Q8J0G6_9SACH DKDGVNHRPA YAIYISG... .......... .......... ..........
Q8J0G5_9SACH D.NGVDQRLS YAISISV... .......... .......... ..........
Q96UY3_9SACH DMNGTKHKIS YAIYMSG... .......... .......... ..........
Q2P9Q8_SACPS DMNGTKHKIS YAIYMSG... .......... .......... ..........
Q874F9_SACPS DMNGTKHKIS YAIYMSG... .......... .......... ..........
Q874H0_YEAST DMNGTKHKIS YAIYMSG... .......... .......... ..........
Q874H2_YEAST DMNGTKHKIS YAIYMSG... .......... .......... ..........
Q874H1_YEAST DMNGTKHKIS YAIYMSG... .......... .......... ..........
Q86Z73_YEAST DMNGTKHKIS YAIYMSG... .......... .......... ..........
Q874G9_YEAST DVNGTKHKIS YAIYMSG... .......... .......... ..........
Q86Z53_YEAST DMNGTKHKIS YAIYMSG... .......... .......... ..........
RGYR_METJA SNKSLETFKE K.IAKYL... .......... .......... ..........
VATA_YEAST DMNGTKHKIS YAIYMSG... .......... .......... ..........
1VDE_A DMNGTKHKIS YAIYMSG... .......... .......... ..........
ss_vde .........S SSSSSS.... .......... .......... ..........
domains .......... .......... .......... .......... ..........
catalyt_resi .......... .......... .......... .......... ..........
cont_type ....HBGB.. ...P...... .......... .......... ..........
sidechain ....+.++.. ...+...... .......... .......... ..........
dna_confirm ....+.+... ...+...... .......... .......... ..........
mut_<10%_active ......+... .......... .......... .......... ..........
2CW8:A ........GV YRVYINE... .......... .......... ..........
ss_2cw8 .......... SSSSS..... .......... .......... ..........
1DQ3:A ......DGID YVLHVEEYSS LLRFYELIGK NLQNEEKREK LEKVLSNHKG
ss_1dq3 ........SS SSSSS..HHH HHHHHHH.HH H...HHHHHH HHHHHH....
ss_align .......... .......... .......... .......... ..........

701 750
Q8J0G2_ZYGRO .......... .......... .......... ....SDALLA VLANCASNNK
Q8J0H2_9SACH .......... .......... .......... ....GELLKS VLSRCSAINY
Q874G1_9SACH .......... .......... .......... .....SALNG VVRLSALSKN
Q8J0G7_9SACH .......... .......... .......... .....SALNG VVRLSALSKN
Q874G4_9SACH .......... .......... .......... .....ATLSG ALRFCALDKN
Q8J0G9_9SACH .......... .......... .......... .....ATLSG ALRFCALDKN
Q874G5_SACCA .......... .......... .......... .....EALIG VLRFCALDRK
Q8J0H0_SACCA .......... .......... .......... .....EALIG VLRFCALDRK
Q2P9R3_DEBHA .......... .......... .......... ....NSALES VLSKCALAEK
Q6BRM0_DEBHA .......... .......... .......... ....NSALES VLSKCALAEK
HO_YEAST .......... .......... .......... ....GTTSQN VLSYCRSGHK
Q9P986_SACPS .......... .......... .......... ....GTTLQN VLSYCRSGHK
Q8J2S8_SACPA .......... .......... .......... ....GTTLQN VLSYCRSGHK
Q9P984_SACBA .......... .......... .......... ....GTTLQN VLSYCRSGHK
Q9P985_SACPS .......... .......... .......... ....GTTLQN VLSYCRSGHK
Q707W4_KLUDE .......... .......... .......... ....SSALQN VLSYCRSGHK
Q707W9_CANGA .......... .......... .......... ....STPLQN VLSYCRSGHK
Q874G2_SACEX .......... .......... .......... ....DALTNS MRF.CAI.GR
Q8J0G8_SACEX .......... .......... .......... ....DALTNS MRF.CAI.GR
Q874G3_SACEX .......... .......... .......... .....DALTN SMRFCAI.GR
VATA_CANTR .......... .......... .......... .....APLAG VLSKCAL.AR
Q6CL64_KLULA .......... .......... .......... .....DALKS VSNWTSTSNI
Q874G6_KLULA .......... .......... .......... .....DALKS VSNWTSTSNI
Q8J0H3_KLULA .......... .......... .......... .....DALKS VSNWTSTSNI
Q8J0H1_9SACH .......... .......... .......... ....GDILLN VLSKCASFKK
Q8J0G3_ZYGBI .......... .......... .......... ....CDALLS VLANCGAVDK
Q8J0G4_ZYGBA .......... .......... .......... ....GDALLS VLAHCAAAKK
Q8J0G6_9SACH .......... .......... .......... ....GDALLS VLANCASAKK
Q8J0G5_9SACH .......... .......... .......... ....SDALLS VLAKCAGAEM
Q96UY3_9SACH .......... .......... .......... ....GDVLLN VLSKCAGSKK
Q2P9Q8_SACPS .......... .......... .......... ....GDVLLN VLSKCAGSKK
Q874F9_SACPS .......... .......... .......... ....GDVLLN VLSKCAGSKK
Q874H0_YEAST .......... .......... .......... ....GDVLLN VLSKCAGSKK
Q874H2_YEAST .......... .......... .......... ....GDVLLN VLSKCAGSKK
Q874H1_YEAST .......... .......... .......... ....GDVLLN VLSKCAGSKK
Q86Z73_YEAST .......... .......... .......... ....GDVLLN VLSKCAGSKK
Q874G9_YEAST .......... .......... .......... ....GDVLLN VLSKCAGSKK
Q86Z53_YEAST .......... .......... .......... ....GDVLLN VLSKCAGSKK
RGYR_METJA .......... .......... .......... ....KIRKEA FINGYKTYKK
VATA_YEAST .......... .......... .......... ....GDVLLN VLSKCAGSKK
1VDE_A .......... .......... .......... ....GDVLLN VLSKCAGSKK
ss_vde .......... .......... .......... ....HHHHHH HHHH......
domains .......... .......... .......... .......... ..........
catalyt_resi .......... .......... .......... .......... .........W
cont_type .......... .......... .......... .......... ..........
sidechain .......... .......... .......... .......... ..........
dna_confirm .......... .......... .......... .......... ..........
mut_<10%_active .......... .......... .......... .......... .........+
2CW8:A .......... ......ELPF VKLDKKKNAY YSHVIPKEVL SEVFGKVFQK
ss_2cw8 .......... .......... .......... HHH...HHHH HHHH......
1DQ3:A GNFGLPLNFN AFKEWASEYG VEFKTNGSQT IAIINDERIS LGQWHTRNRV
ss_1dq3 ...SS...HH HHHHHHH... .SSSSS..SS SSSS..SSSS ...HHHH..S
ss_align .......... .......... .......... .......... ..........

751 800
Q8J0G2_ZYGRO QIEAPPHGVI REF....... .......... .NKAYF.EME ELEE..DEYY
Q8J0H2_9SACH TKCESR.DLL REP....... .......... .VEFYF.ELQ ELEE..AEYY
Q874G1_9SACH .RDEPV.SFE RLP....... .......... .VPFHF.TLL EKAE..DNYY
Q8J0G7_9SACH .RDEPV.SFE RLP....... .......... .VPFHF.TLL EKAE..DNYY
Q874G4_9SACH NANSKK.PFV RGP....... .......... .VPFYF.TLK EKDE..DNYY
Q8J0G9_9SACH NANSKK.PFV RGP....... .......... .VPFYF.TLK EKDE..DNYY
Q874G5_SACCA .RTAFK.EFT REA....... .......... .VPFYF.TLQ EKDQ..DEYY
Q8J0H0_SACCA .RTAFK.EFT REA....... .......... .VPFYF.TLQ EKDQ..DEYY
Q2P9R3_DEBHA TTSVPS.HIT RTG....... .......... .QNFDF.SVK KIEA..ADYY
Q6BRM0_DEBHA TTSVPS.HIT RTG....... .......... .QNFDF.SVK KIEA..ADYY
HO_YEAST TREVPP.IIK REP....... .......... .VYFSF.TDD FQGE..STVY
Q9P986_SACPS TREVPP.IIK REP....... .......... .VYFSF.TDD FQGE..STVY
Q8J2S8_SACPA TREVPL.IVK RQA....... .......... .VYFGF.TDD FQGE..STVY
Q9P984_SACBA TREIPP.IVK REP....... .......... .VYFGF.TDD FQGE..STVY
Q9P985_SACPS TREIPP.IVK REP....... .......... .VYFGF.TDD FQGE..STVY
Q707W4_KLUDE RRKAPE.SVI REP....... .......... .QFFGF.IDK KISE..ADVK
Q707W9_CANGA RKPAPE.VVI RDP....... .......... .QYVGF.IDR KLRE..AEVY
Q874G2_SACEX NRVTAK.QFM RQA....... .......... .IPFYF.SLE KKSE..DDYY
Q8J0G8_SACEX NRVTAK.QFM RQA....... .......... .IPFYF.SLE KKSE..DDYY
Q874G3_SACEX NRVAAK.EFM RQA....... .......... .VPFYF.SLE KKSE..DDYY
VATA_CANTR NQTPVV.KFT RDP....... .......... .VLFNF.DLI KSAK..ENYY
Q6CL64_KLULA EKVD....VI HKA....... .......... .QPISF.DLE KIES..ADYF
Q874G6_KLULA EKVD....VI HKA....... .......... .QPISF.DLE KIES..ADYF
Q8J0H3_KLULA EKVD...VIH K.A....... .......... .QPISF.DLE KIES..ADYF
Q8J0H1_9SACH FRPAPVAPPV REC....... .......... .RGFYF.ELQ ELEE..DDYY
Q8J0G3_ZYGBI RREAPAHGVI REL....... .......... .NKVYF.EMR ELGE..DEYY
Q8J0G4_ZYGBA FRAPPSNEVV RGL....... .......... .KKVFF.EME ELKE..DDYY
Q8J0G6_9SACH HRAAPTKEVV RGL....... .......... .NEVYF.EMK ELQE..DDYY
Q8J0G5_9SACH FRELPASEVV RKM....... .......... .NKVYF.EME ELEE..DDYY
Q96UY3_9SACH FRPAPVATFV REC....... .......... .QGFYF.ELQ ELKE..NDYY
Q2P9Q8_SACPS FRPAPVATFV REC....... .......... .QGFYF.ELQ ELKE..NDYY
Q874F9_SACPS FRPAPVATFV REC....... .......... .QGFYF.ELQ ELKE..NDYY
Q874H0_YEAST FRPAPVATFV REC....... .......... .QGFYF.ELQ ELKE..NDYY
Q874H2_YEAST FRPAPAAAFA REC....... .......... .RGFYF.ELQ ELKE..DDYY
Q874H1_YEAST FRPAPAAAFA REC....... .......... .RGFYF.ELQ ELKE..DDYY
Q86Z73_YEAST FRPAPVATFV REC....... .......... .QGFYF.ELQ ELKE..NDYY
Q874G9_YEAST FRPAPAAAFA REC....... .......... .RGFYF.ELQ ELKE..DDYY
Q86Z53_YEAST FRPAPAAAFA REC....... .......... .PGFYF.ELQ ELKE..DDYY
RGYR_METJA EHEE...... RFE....... .......... .CDLLP.VKE VFKK..LTFE
VATA_YEAST FRPAPAAAFA REC....... .......... .RGFYF.ELQ ELKE..DDYY
1VDE_A FRPAPAAAFA REC....... .......... .RGFYF.ELQ ELKE..DDYY
ss_vde .......... .......... .......... .SSS.S.SSS SSSS..SSSS
domains .......... .><....... .......... .........S PLICING...
catalyt_resi .......... .......... .......... .......... ..........
cont_type .......... .......... .......... .......... ..........
sidechain .......... .......... .......... .......... ..........
dna_confirm .......... .......... .......... .......... ..........
mut_<10%_active .......... .......... .......... .......... ..........
2CW8:A NVSPQTFRKM VEDGRLDPEK AQRLSWLIEG DVVLDRVESV DVEDYDGYVY
ss_2cw8 ...HHHHHHH HH.....HHH HHHHHHHHH. .SSSSSSSSS SSSSSSSSSS
1DQ3:A SKAVLVKMLR KLYEATKDEE VKRMLHLIEG ..LEVVRHIT TTNE.PRTFY
ss_1dq3 SHHHHHHHHH HHHHHH..HH HHHHHHHHHH ...SSSSSSS SS....SSSS
ss_align .......... .......... .......... .+++++.+++ ++++..++++

801 850
Q8J0G2_ZYGRO GLTLSNESDH QFLLA.NQ.L VVHN...... .......... ..........
Q8J0H2_9SACH GITLPEYSDH QFMLS.NQ.V VVHN...... .......... ..........
Q874G1_9SACH GVTLPDATDK QYLLS.SL.A LVHN...... .......... ..........
Q8J0G7_9SACH GVTLPDATDK QYLLS.SL.A LVHN...... .......... ..........
Q874G4_9SACH GITLPDSTDK QYLLS.SL.A LVHN...... .......... ..........
Q8J0G9_9SACH GITLPDSTDK QYLLS.SL.A LVHN...... .......... ..........
Q874G5_SACCA GITLPDETDK QYLLS.SL.A LVHN...... .......... ..........
Q8J0H0_SACCA GITLPDETDK QYLLS.SL.A LVHN...... .......... ..........
Q2P9R3_DEBHA GVTLPDNSDH QFMLA.NQ.A VVHN...... .......... ..........
Q6BRM0_DEBHA GVTLPDNSDH QFMLA.NQ.A VVHN...... .......... ..........
HO_YEAST GLTIEGHKN. .FLLG.NK.I EVKS...... .......... ..........
Q9P986_SACPS GLTIEGHKN. .FLLG.NK.I EVKS...... .......... ..........
Q8J2S8_SACPA GLTIEGHKN. .FLLG.NK.I EVKS...... .......... ..........
Q9P984_SACBA GLHIEGHKS. .YLLG.NK.I EVKS...... .......... ..........
Q9P985_SACPS GLHIEGHKS. .YLLG.NK.I EVKS...... .......... ..........
Q707W4_KLUDE GIHFEDERN. .ILLG.NK.V VAHC...... .......... ..........
Q707W9_CANGA GIHLDQPRN. .ILLG.NK.I VVYS...... .......... ..........
Q874G2_SACEX GITVPDNTDK QYLLS.SM.A LVHN...... .......... ..........
Q8J0G8_SACEX GITVPDNTDK QYLLS.SM.A LVHN...... .......... ..........
Q874G3_SACEX GITVPDNTDK QYLLS.SM.A LVHN...... .......... ..........
VATA_CANTR GITLAEETDH QFLLS.NM.A LVHN...... .......... ..........
Q6CL64_KLULA GVTLAEESDH KFLLS.NM.T LVHN...... .......... ..........
Q874G6_KLULA GVTLAEESDH KFLLS.NM.T LVHN...... .......... ..........
Q8J0H3_KLULA GVTLAEESDH KFLLS.NM.T LVHN...... .......... ..........
Q8J0H1_9SACH GITLSDDSDH QFLLA.NQ.V VVHN...... .......... ..........
Q8J0G3_ZYGBI GLTLSNDSDH QFLLA.NQ.L VVHN...... .......... ..........
Q8J0G4_ZYGBA GITLAKESDH QFLLA.NQ.L VVHN...... .......... ..........
Q8J0G6_9SACH GITLSENSDH QFMLA.NQ.L VVHN...... .......... ..........
Q8J0G5_9SACH GLTLANGTDH QFMLA.NQ.L VVHN...... .......... ..........
Q96UY3_9SACH GITLSDDSDH QFLLA.NQ.V VVHN...... .......... ..........
Q2P9Q8_SACPS GITLSDDSDH QFLLA.NQ.V VVHN...... .......... ..........
Q874F9_SACPS GITLSDDSDH QFLLA.NQ.V VVHN...... .......... ..........
Q874H0_YEAST GITLSDDSDH QFLLA.NQ.V VVHN...... .......... ..........
Q874H2_YEAST GITLSDDSDH QFLLA.NQ.V VVHN...... .......... ..........
Q874H1_YEAST GITLSDDSDH QFLLA.NQ.V VVHN...... .......... ..........
Q86Z73_YEAST GITLSDDSDH QFLLA.NQ.V VVHN...... .......... ..........
Q874G9_YEAST GITLSDDSDH QFLLA.NQ.V VVHN...... .......... ..........
Q86Z53_YEAST GITLSDDSDH QFLLA.NQ.V VVHN...... .......... ..........
RGYR_METJA KGRKEILKDS KIHIE.NW.Y KEKTNNIPRE KLKTVLRYAN NSEHKEFLEK
VATA_YEAST GITLSDDSDH QFLLA.NQ.V VVHN...... .......... ..........
1VDE_A GITLSDDSDH QFLLA.NQ.V VVHN...... .......... ..........
ss_vde ..SS...... SSS....... SSS....... .......... ..........
domains .......... .......... ...>...... .......... ..........
catalyt_resi .......... .......... .......... .......... ..........
cont_type .......... .......... .......... .......... ..........
sidechain .......... .......... .......... .......... ..........
dna_confirm .......... .......... .......... .......... ..........
mut_<10%_active .......... .......... .......... .......... ..........
2CW8:A DLSVE..DNE NFLVGF.GLV YAHN...... .......... ..........
ss_2cw8 SSSS...... SSSS.....S SSS....... .......... ..........
1DQ3:A DLTVE..NYQ NYLAGENGMI FVHN...... .......... ..........
ss_1dq3 SSSS...... SSSSS....S SSS....... .......... ..........
ss_align ++.++..+++ +++++.++.+ ++++...... .......... ..........

851 899
Q8J0G2_ZYGRO .......... .......... .......... .......... .........
Q8J0H2_9SACH .......... .......... .......... .......... .........
Q874G1_9SACH .......... .......... .......... .......... .........
Q8J0G7_9SACH .......... .......... .......... .......... .........
Q874G4_9SACH .......... .......... .......... .......... .........
Q8J0G9_9SACH .......... .......... .......... .......... .........
Q874G5_SACCA .......... .......... .......... .......... .........
Q8J0H0_SACCA .......... .......... .......... .......... .........
Q2P9R3_DEBHA .......... .......... .......... .......... .........
Q6BRM0_DEBHA .......... .......... .......... .......... .........
HO_YEAST .......... .......... .......... .......... .........
Q9P986_SACPS .......... .......... .......... .......... .........
Q8J2S8_SACPA .......... .......... .......... .......... .........
Q9P984_SACBA .......... .......... .......... .......... .........
Q9P985_SACPS .......... .......... .......... .......... .........
Q707W4_KLUDE .......... .......... .......... .......... .........
Q707W9_CANGA .......... .......... .......... .......... .........
Q874G2_SACEX .......... .......... .......... .......... .........
Q8J0G8_SACEX .......... .......... .......... .......... .........
Q874G3_SACEX .......... .......... .......... .......... .........
VATA_CANTR .......... .......... .......... .......... .........
Q6CL64_KLULA .......... .......... .......... .......... .........
Q874G6_KLULA .......... .......... .......... .......... .........
Q8J0H3_KLULA .......... .......... .......... .......... .........
Q8J0H1_9SACH .......... .......... .......... .......... .........
Q8J0G3_ZYGBI .......... .......... .......... .......... .........
Q8J0G4_ZYGBA .......... .......... .......... .......... .........
Q8J0G6_9SACH .......... .......... .......... .......... .........
Q8J0G5_9SACH .......... .......... .......... .......... .........
Q96UY3_9SACH .......... .......... .......... .......... .........
Q2P9Q8_SACPS .......... .......... .......... .......... .........
Q874F9_SACPS .......... .......... .......... .......... .........
Q874H0_YEAST .......... .......... .......... .......... .........
Q874H2_YEAST .......... .......... .......... .......... .........
Q874H1_YEAST .......... .......... .......... .......... .........
Q86Z73_YEAST .......... .......... .......... .......... .........
Q874G9_YEAST .......... .......... .......... .......... .........
Q86Z53_YEAST .......... .......... .......... .......... .........
RGYR_METJA IVNGDISFVR VKKVENIPYD GYVYDLSIKH NQNFISNGVI SHNCTYHRT
VATA_YEAST .......... .......... .......... .......... .........
1VDE_A .......... .......... .......... .......... .........
ss_vde .......... .......... .......... .......... .........
domains .......... .......... .......... .......... .........
catalyt_resi .......... .......... .......... .......... .........
cont_type .......... .......... .......... .......... .........
sidechain .......... .......... .......... .......... .........
dna_confirm .......... .......... .......... .......... .........
mut_<10%_active .......... .......... .......... .......... .........
2CW8:A .......... .......... .......... .......... .........
ss_2cw8 .......... .......... .......... .......... .........
1DQ3:A .......... .......... .......... .......... .........
ss_1dq3 .......... .......... .......... .......... .........
ss_align .......... .......... .......... .......... .........