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PhD opportunity in UK




|PhD Studentship starting September 2007 |
|'Structural biology of bacterial motility' |
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|Applications are invited from top 5% final-year |
|biophysics/biochemistry students to undertake PhD studies on the |
|molecular mechanism of torque generation in bacterial flagellar |
|motor at the University of Manchester, UK. Flagellar motors are |
|membrane-embedded molecular machines that rotate filaments, |
|providing a propulsive force for bacteria to swim toward |
|nutrients, optimal temperatures or other factors that favour |
|survival. The rotation is powered by the gradient of hydrogen or |
|sodium ions across the cytoplasmic membrane. We aim to elucidate |
|the molecular mechanism of conversion of the electrochemical |
|energy of the transmembrane proton gradient into the mechanical |
|energy of flagellar rotation. This complex biological question |
|can be addressed through investigation of the properties and the |
|three-dimensional structure of the individual components and |
|domains of the power-generating stator unit of the motor. A PhD |
|student would join the project to investigate the precise role of|
|extramembrane domains of MotA and MotB proteins in interaction |
|with the peptidoglycan layer, assembly of the stator unit and |
|interaction with the rotor protein FliG. This work will involve |
|the use a range of techniques including X-ray crystallography, |
|CD, SPR, ITC, AUC, small angle scattering and, if required, NMR, |
|which will give a student an excellent opportunity to advance |
|their knowledge and practical skills in biochemistry, biophysics |
|and structural biology. |
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|Further Information |
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|Successful candidates will receive an Overseas Research Student |
|Award which covers tuition fees. |
| |
|Further information can be obtained by contacting Dr Anna |
|Roujeinikova: Anna.Roujeinikova@manchester.ac.uk |
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|http://www.mib.ac.uk/details.aspx?val=97927 |
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