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Moscow University Chemistry Bulletin Vol. 52, No. 6, P. 449 (2011)
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A. V. Severin, G. A. Badun, M. G. Chernysheva

Studying the nature of interaction between nanohydroxyapatite and albumins by radionu clide-microscopy diagnostics

Abstract

Multistage character of adsorption isotherms of human and bovine serum albumins on hydroxyapatite nanoparticles from aqueous solution have been developed by radionuclide-microscopy method. Such isotherms character indicated the number of physicalchemical processes: formation of the peptide-nanohydroxyapatite complex and following by aggregation in liquid and solid phases. This hypothesis was confermed by X-ray and dynamic light-scattering analysis. It was shown, that when hydroxyapatite is formed in albumin solution the peptide-nanohydroxyapatite complex formation is followed by morphology and structure exchange of hydroxyapatite nanocrystals.
Moscow University Chemistry Bulletin.
2011, Vol. 52, No. 6, P. 449
   

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