Äîêóìåíò âçÿò èç êýøà ïîèñêîâîé ìàøèíû. Àäðåñ îðèãèíàëüíîãî äîêóìåíòà : http://www.chem.msu.ru/rus/vmgu/124/234.pdf
Äàòà èçìåíåíèÿ: Tue Apr 17 17:49:01 2012
Äàòà èíäåêñèðîâàíèÿ: Fri Feb 28 02:59:30 2014
Êîäèðîâêà:


â °



234

. . -. . 2. . 2012. . 53. 4

615.2/3.07:544 174

.
.. , .. , .. ( ; e-mail: sig@genebee.msu.su)
-, . , (X-Ray Powder Diffraction), , , , .

: , , , , -, , .

. ( ­ 95%) ( ) , [1] () ( ) , . - [2]. ( , , , , ), . ­ . . , , ­ . , , , , . [3].

, , . , , . , , . , , , . . [4]. , , . . , D- ­ , ,


. . -. . 2. . 2012. . 53. 4

235

50­70 , L- [1]. : , , . , , . L-, 8­10 D-, . , . D L ( ) , , . (80­160 ) (5­10 ) [4]. . , , , . ( , , ). . . : 5-[(3,4- )-]-2-(3,4)-2- [?]. . ( X-Ray Powder Diffraction) X-Ray Powder Diffraction (XRPD, -

) ­ ? . , ( ) . , , . . , X-Ray . XRPD () . XRPD . , , (- ) . [5]. . 1 XRPD . «X-Ray 3070E» X-Ray Powder Diffraction . (DSC, ) ( ) : , , . 300 -


236

. . -. . 2. . 2012. . 53. 4

. 1. X-Ray-

[6]. - . «TGA Q500» «TA Instruments» . , , .. . «DSC Q100» «TA Instruments» 50 / ( , ).

10°/ // : 1) 10°/; 2) 0° 10°/; 3) 0° 10°/. 1 2 170°C. 2 8 . «DSC Q100 TA Instruments Thermal Advantage» ( 4.3). . 2­5. 1 2


. . -. . 2. . 2012. . 53. 4

237

, [7]. , (-, ) , , . (IR- ) (-) ­ , -, .. 10­6 10­3 . ­ ( ) - . . ( , , ) , , , . - , . -. -: :, , ( ) , ( 0,001 ­1). - «Nicolet 380», -

. 2. - 1 2

. 3. 1 ( )

. 4. 2 ( )

( ). 10°C/ , . ,

. 5. 1 2 ( )


238

. . -. . 2. . 2012. . 53. 4

. 6. - 1 2

() «Smart Performer». 4 ­1, 4000­500 ­1, 1 . OMNIC 7.3, , . . 6 - . . . , , , . () , , . , , , - . 400­1000 , -. . 7

. , . , , X-Ray powder diffraction, -, , , - .




. 7 . 400-


. . -. . 2. . 2012. . 53. 4

239

( ) , (). [8, 9]. () . , L D-. , . . . . - . , 275 ( ) ~1,0±0,2. - (. 8) «Hitachi» () 200­400 . 1 . - (. 9) «Yobin Yvon Mark» () 220­400 , 1â10­5. , . . 8, - = 230 = 280 , . - ,

. 8. - : 1, 2, 3 ­ ; 4 , 5 ­

. 9. R+ 1 ­ 1, 2 ­ 3 ­ 3, 4 ­ 4

280 . , . . R+- ( ) 280 . , . . .

.. // , 2000. 37. 1. .29. ..; ., // . 2006. 5. .22. . // . ., 2007. .. // . 1998. 1. .49.


240 Byrn S, Pfeiffer R, Ganey M, // Pharm. Res..1995. 12. N 7. P. 945. Giron D. // J.Therm.Anal. and Calorimetry. 2001. 64. P.37. 7. .. , .., .., / / - . 2010. 1. . 39 ., . // . ., 1984. 2. . 63.

. . -. . 2. . 2012. . 53. 4 ., .., . // . . . . . 2. ., 2010. .. // . . 2. 1984. . 427. British Pharmacopoeia.: Medicinal and Pharmaceutical substances. Vol. 1. 2001. C. 1.
20.03.12

ANALYSIS OF CRYSTALLINE STRUCTURE AND CHIRALITY OF DRUG SUBSTANCES
I.G. Smirnova, G.N. Gildeeva, V.V. Chistyakov (Department of Chemistry of Natural Products)
The change in substance's crystalline state or chirality influence on physical and chemival, pharmacotechnological features as well as bioavailability of pharmaceuticals. It was identified that such methods as X-Ray Powder Diffraction, infrared Fourier transform spectroscopy, differential scanning calorimetry, optical microscopy, circular dichroism can be successfully used for quality control of medical preparation.

Key words: drags, polymorphism of drag substances, polymorphic modification, assay, UV-spectroscopy, optical isomerism, circular dichroism.
: ­ . . ., , . . , (sig@genebee.msu.ru); ­ , . . , ; ­ . , . . .

. 9,