... Several compounds of platinum, e.g. cisplatin and carboplatin, display strong cytostatic acitvity and are potent anticancer drugs, widely used in clinics. Extensive studies of mechanism of action of platinum drugs and platinum-induced DNA damage were held in last decades. ... Though platination of pure DNA is a well studied process, the relative rates of reactions with therapy target (DNA), and toxicity and side targets (proteins) are poorly studied, and many controversies remain. ...