... We study the effect of modification free SH-groups level of superficial proteins (pHMB affect), mild proteolysis of the superficial nerve proteins (pronase Е) and sorption on the nerve alien protein OspA (isolated from Borrelia burgdorferi sensu stricto) on the axon-Shwann cell interactions. ... Aplying Raman spectroscopy we have showed the decrease in the axolemma microviscosity (AM) during binding of free SH-groups and sorbtion of OspA, and the increase in AM under the nerve proteins proteolysis. ...