Understanding of the cAMP-induced conformational transition of Protein Kinase A I A-domain. ... Others [2] demonstrate that low-polar residues isoleucine or threonine at position 209 are relatively benign in their effects on transition mechanism, whereas basic lysine, which seems to be a good candidate for maintaining switch function, behaves almost as well as glutamic acid and makes A-domain about 20-times less sensitive to cAMP than isoleucine. ...

Еще в разделе: (Показать все результаты (>3) - mccmb.belozersky.msu.ru/ )

• http://mccmb.belozersky.msu.ru/2015/proceedings/abstracts/51.pdf

Some additional inquiry information . ... WPGMA . As any cluster method , UPGMA (unweighted pair-group method of analysis) performs the structure of a set of some homogeneous elements ( in our case alignment is a set of amino acid sequences ). ... Firstly, when we calculate correlations between distance matrices on the whole alignment and on separate position (for selecting "diagnostic" positions) - we should be sure that these data are not distorted by multiple repeating of one sequence. ...

Еще в разделе: (Показать все результаты (>2) - monkey.belozersky.msu.ru/ )

Muller cells are living optical fibers ? in the vertebrate retina Kristian Franze*, Jens Grosche*, Serguei N. Skatchkov, Stefan Schinkingerї, Christian FojaІ, Detlev Schild , Ortrud Uckermann*, ... California, Berkeley, CA, and accepted by the Editorial Board March 27, 2007 (received for review December 15, 2006) Although biological cells are mostly transparent, they are phase objects that differ in shape and refractive index ... 20 8287ґ 8292 BIOPHYSICS Fig. ... Fig. ... Cell Isolation. ...