Microvascular Research 67 (2004) 64 ґ 77 www.elsevier.com/locate/ymvre Role of Rho GTPases in thrombin -induced lung vascular endothelial cells barrier dysfunction Anna A. Birukova, a Ksenya Smurova, a,b Konstantin G. Birukov, a Kozo Kaibuchi, Joe G.N. Garcia, a and Alexander D. Verin a,* a c Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA b Belozersky Institute of Physico ... Effect of thrombin on MLC phosphorylation. ...