Protein 3D architectures and structural motifs: automated annotation E.A. Aksianov1, A.V. Alexeevski 1 2 1,2 Belozersky Institute, Lomonosov Moscow State University, Leninskie Gori 1, Moscow, Russia Scientific Research Institute for System Studies (NIISI RAN), Moscow, Russia evaksianov@gmail.com, aba@belozersky.msu.ru Description of a protein 3D structure in terms of structural domains, architecture, topology and structural motifs is a hard problem. ... The core is extended by small -sheet (unit_3). ...

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... Distances between sequences . It is considered that the space, where all amino acids and sequences are analysed, is a metric one. ... When the distance between amino acids is entered, it is rather easy to consider such measure as pair distance between sequences in any position of alignment (in fact, this distance is just a distance between two amino acids). As distance is an additional quantity, pair distance between sequences on all alignment positions can be easily defined. ...

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... Cofilin weakly interacts with 14-3-3 and therefore can only indirectly participate in regulation of cell motility by small heat shock protein HspB6 (Hsp20). ... It has been previously reported that phosphorylated cofilin interacted with 14-3-3zeta protein to generate a sub-micromolar K(d) binary complex. ... Thus, cofilin only weakly interacts with 14-3-3 and therefore cannot directly compete with phosphorylated small heat shock protein HspB6 for its binding to 14-3-3. ...

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. Nhunt: program for nucleic acid sequence similarity search . Download . User manual . Application examples . License . News . About . Authors publications . Contacts . Web interface . At present you can download poster from MCCMB'11 conference and my term work (in Russian) with description of main program algorithms. Funding: Ministry of Education and Science of the Russian Federation (State Contract No. 07.514.11.4006). Copyright 2010-2011 Yury Pekov

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... Credit Copyright: HST , ESA , NASA Explanation: "Beautiful Nebula discovered between the Balance [Libra] the Serpent [Serpens] ..." begins the description of the 5th entry in 18th century astronomer Charles Messier's famous catalog of nebulae and star clusters. Though it appeared to Messier to be fuzzy and round and without stars, Messier 5 (M5) is now known to be a globular star cluster, 100,000 stars or more, bound by gravity and packed into a region around 165 light-years in diameter. ...

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