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321. Carnosine protects neurons against oxidative stress and modulates the time
... Carnosine protects neurons against oxidative stress and modulates the time profile of MAPK cascade signaling. ... Using the model of ligand-dependent oxidative stress in neurons, we have shown that homocysteine (HC) initiates long-term activation of extracellular signal regulated kinase, isoforms 1 and 2 (ERK 1/2) and Jun N-terminal kinase (JNK) which corresponds to exitotoxic effect resulting in cellular death. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=22101981 -- 4.2 Кб -- 02.02.2013
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322. Expression, purification and some properties of fluorescent chimeras of human
... Expression, purification and some properties of fluorescent chimeras of human small heat shock proteins. ... Protein Expr Purif. ... To determine the properties of these chimeras, we fused enhanced yellow and cyan fluorescent proteins (EYFP and ECFP) to the N-termini of four ubiquitously expressed human small heat shock proteins: HspB1, HspB5, HspB6, and HspB8. The eight fluorescent chimeras of small heat shock proteins and isolated fluorescent proteins were expressed in Escherichia coli. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=22100527 -- 5.4 Кб -- 02.02.2013
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323. Synergetic inhibition of the brain mitochondrial NADH:ubiquinone oxidoreductase
... Synergetic inhibition of the brain mitochondrial NADH:ubiquinone oxidoreductase (complex I) by fatty acids and Ca2+. ... The inhibition is completely reversed by either EGTA or by bovine serum albumin (BSA). ... Acta, 1098, 144-150) inhibitory effect of Ca2+ and alkaline pH on the de-active-to-active form transition of complex I. A possible mechanism of synergetic inhibition on complex I by Ca2+ and fatty acids is discussed. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=22022971 -- 4.0 Кб -- 02.02.2013
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324. Large potentials of small heat shock proteins.
... Large potentials of small heat shock proteins. ... HSPB1 directly or indirectly participates in the regulation of apoptosis, protects the cell against oxidative stress, and is involved in the regulation of the cytoskeleton. ... All small heat shock proteins play important "housekeeping" roles and regulate many vital processes; therefore, they are considered as attractive therapeutic targets. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=22013208 -- 4.3 Кб -- 02.02.2013
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325. Heterooligomeric complexes of human small heat shock proteins.
... Heterooligomeric complexes of human small heat shock proteins. ... Oligomeric association of human small heat shock proteins HspB1, HspB5, HspB6 and HspB8 was analyzed by means of size-exclusion chromatography, analytical ultracentrifugation and chemical cross-linking. Wild-type HspB1 and Cys mutants of HspB5, HspB6 and HspB8 containing a single Cys residue in position homologous to that of Cys137 of human HspB1 were able to generate heterodimers cross-linked by disulfide bond. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=22002549 -- 4.1 Кб -- 02.02.2013
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326. Properties of the monomeric form of human 14-3-3zeta protein and its
... Properties of the monomeric form of human 14-3-3zeta protein and its interaction with tau and HspB6. ... Using WMW and MMW mutants, we show that the monomeric form interacts with the tau protein and with the HspB6 protein, in both cases forming complexes with a 1:1 stoichiometry, in contrast to the 2:1 and/or 2:2 complexes formed by wild-type 14-3-3. Significantly, this interaction requires phosphorylation of tau protein and HspB6. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=21978388 -- 4.9 Кб -- 02.02.2013
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327. Pinealon increases cell viability by suppression of free radical levels and
... Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes. ... At the same time, pinealon decreases necrotic cell death measured by the propidium iodide test. The protective effect of pinealon is accompanied with a delayed time course of ERK 1/2 activation and modification of the cell cycle. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=21978084 -- 4.3 Кб -- 02.02.2013
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328. Probable participation of 14-3-3 in tau protein oligomerization and...
... Probable participation of 14-3-3 in tau protein oligomerization and aggregation. ... This review is focused on universal adapter proteins 14-3-3 that seem to be significant partners to tau protein in neurons. 14-3-3 interacts with nonphosphorylated tau and promotes its interaction with and phosphorylation by a number of protein kinases. 14-3-3 induces aggregation of nonphosphorylated tau and does not affect aggregation of tau phosphorylated at specific sites. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=21876254 -- 4.6 Кб -- 02.02.2013
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329. Three-dimensional structure of alpha-crystallin domain dimers of human small
... Three-dimensional structure of alpha-crystallin domain dimers of human small heat shock proteins HSPB1 and HSPB6. ... Small heat shock proteins (sHSPs) are a family of evolutionary conserved ATP-independent chaperones. ... To further analyze the structure of ACD dimers, we have employed a combination of X-ray crystallography and solution small-angle X-ray scattering (SAXS) to study the ACD-containing fragments of human HSPB1 (HSP27) and HSPB6 (HSP20). ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=21641913 -- 5.1 Кб -- 02.02.2013
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330. Allosteric nucleotide-binding site in the mitochondrial NADH:ubiquinone
... Allosteric nucleotide-binding site in the mitochondrial NADH:ubiquinone oxidoreductase (respiratory complex I). ... Epub 2011 May 27. ... The rotenone-insensitive NADH:hexaammineruthenium III (HAR) oxidoreductase reactions catalyzed by bovine heart and Yarrowia lipolytica submitochondrial particles or purified bovine complex I are stimulated by ATP and other purine nucleotides. ... Thus, the "accessory" subunits of eukaryotic complex I bear an allosteric ATP-binding site. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=21624365 -- 3.8 Кб -- 02.02.2013
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331. Phosphorylation of human small heat shock protein HspB8 (Hsp22) by ERK1 protein
... Phosphorylation of human small heat shock protein HspB8 (Hsp22) by ERK1 protein kinase. ... A number of phosphomimicking mutants (replacement of Ser/Thr residues by Asp) of human small heat shock protein HspB8 were obtained and phosphorylation of the wild type HspB8 and its mutants by ERK1 kinase was analyzed in vitro. Mutation S159D does not affect phosphorylation, whereas mutations S24D and S27D equally moderately inhibited and mutation T87D strongly inhibited phosphorylation of HspB8. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=21526341 -- 4.4 Кб -- 02.02.2013
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332. Human pro-B-type natriuretic peptide is processed in the circulation in a rat
... Human pro-B-type natriuretic peptide is processed in the circulation in a rat model. ... BACKGROUND: The appearance of B-type natriuretic peptide (BNP) in the blood is ultimately caused by proteolytic processing of its precursor, proBNP. ... RESULTS: ProBNP was effectively processed in the circulation into BNP (1-32) and various truncated BNP forms as confirmed by gel filtration and MS analysis. ... CONCLUSIONS: In rats, processing of human proBNP to active BNP occurs in the circulation. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=21474642 -- 5.2 Кб -- 02.02.2013
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333. Molecular identification of the enzyme responsible for the mitochondrial
... Molecular identification of the enzyme responsible for the mitochondrial NADH-supported ammonium-dependent hydrogen peroxide production. ... A homogeneous protein with a subunit apparent molecular mass of approximately 50 kDa that catalyzes the previously described mitochondrial NADH-supported ammonium-stimulated hydrogen peroxide production (Grivennikova, V.G., Gecchini, G. and Vinogradov, A.D. (2008) FEBS Lett. 583, 1287-1291) was purified from the mitochondrial matrix of bovine heart. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=21168410 -- 4.1 Кб -- 02.02.2013
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334. Phosphomimicking mutations of human 14-3-3zeta affect its interaction with tau
... Phosphomimicking mutations of human 14-3-3zeta affect its interaction with tau protein and small heat shock protein HspB6. ... Effect of phosphomimicking mutations of 14-3-3zeta on its interaction with phosphorylated shortest isoform of human tau protein and phosphorylated human small heat shock protein HspB6 (Hsp20) was analyzed. ... The mutation mimicking phosphorylation of Ser184 does not markedly affect interaction with tau protein and improves the interaction of 14-3-3 with HspB6. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=21081103 -- 4.8 Кб -- 02.02.2013
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335. Measurement of B-type natriuretic peptide by two assays utilizing antibodies
... Measurement of B-type natriuretic peptide by two assays utilizing antibodies with different epitope specificity. ... DESIGN AND METHODS: Plasma samples (n=94) from HF patients were analyzed by the novel-type "Single Epitope Sandwich" (SES assay prototype) and the conventional-type Siemens ADVIA Centaur BNP assays. ... RESULTS: The SES assay measured 1.2- to 7.2-fold (2.1+/-0.9; mean, SD) greater BNP concentrations compared to the Siemens assay. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=20950595 -- 4.4 Кб -- 02.02.2013
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336. Interaction of Hsp27 with native phosphorylase kinase under crowding...
... Interaction of Hsp27 with native phosphorylase kinase under crowding conditions. ... Interaction of the wild type (wt) heat shock protein Hsp27 and its three-dimensional (3D) mutant (mimicking phosphorylation at Ser15, 78, and 82) with rabbit skeletal muscle phosphorylase kinase (PhK) has been studied under crowding conditions modeled by addition of 1 M trimethylamine N-oxide (TMAO). ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=20491124 -- 4.1 Кб -- 02.02.2013
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337. Processing of pro-B-type natriuretic peptide: furin and corin as candidate
... Processing of pro-B-type natriuretic peptide: furin and corin as candidate convertases. ... BACKGROUND: B-type natriuretic peptide (BNP) and its N-terminal fragment (NT-proBNP) are the products of the enzyme-mediated cleavage of their precursor molecule, proBNP. ... We investigated the role of 2 candidate convertases, furin and corin, in human proBNP processing. ... CONCLUSIONS: Both furin and corin are involved in the proBNP processing pathway, giving rise to distinct BNP forms. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=20489134 -- 5.2 Кб -- 02.02.2013
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338. Functional NMDA receptors in rat erythrocytes.
... Functional NMDA receptors in rat erythrocytes. ... These channels have a 10-fold higher permeability for Ca(2+) compared with Na(+) or K(+) and binding of the agonists (glutamate, homocysteine, homocysteic acid, NMDA) triggers Ca(2+) uptake. The present study demonstrates the presence of NMDA receptors in rat erythrocytes. ... Treatment of erythrocytes with NMDA receptor agonists leads to a rapid increase in intracellular Ca(2+) resulting in a transient shrinkage via Gardos channel activation. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=20457837 -- 4.8 Кб -- 02.02.2013
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339. NMDA receptors are expressed in lymphocytes activated both in vitro and in...
... NMDA receptors are expressed in lymphocytes activated both in vitro and in vivo. ... Cell Mol Neurobiol. ... Epub 2010 Apr 23. ... In the present study, we have shown that some intact lymphocytes express N-methyl-D: -aspartate activated receptors (NMDA receptors), an important constituent of glutamatergic system. The activation of lymphocytes with phytohemagglutinin (PHA) induces a time-dependent increase in the amount of NMDA receptor presenting cells, and NMDA stimulates this process. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=20414717 -- 4.2 Кб -- 02.02.2013
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340. Thermal stability and aggregation of creatine kinase from rabbit skeletal
... Thermal stability and aggregation of creatine kinase from rabbit skeletal muscle. Effect of 2-hydroxypropyl-beta-cyclodextrin. ... Effect of 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) on thermal aggregation of creatine kinase from rabbit skeletal muscle (RMCK) at 48 degrees C has been studied using dynamic light scattering. ... It has been shown that the initial parts of the dependences of the hydrodynamic radius (R(h)) of the protein aggregates on time follow the exponential law. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=20378240 -- 4.5 Кб -- 02.02.2013
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