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341. What are the sources of hydrogen peroxide production by heart mitochondria?
... What are the sources of hydrogen peroxide production by heart mitochondria? ... Coupled rat heart mitochondria produce externally hydrogen peroxide at the rates which correspond to about 0.8 and 0.3% of the total oxygen consumption at State 4 with succinate and glutamate plus malate as the respiratory substrates, respectively. ... The residual activity is strongly (approximately 6-fold) stimulated by ammonium chloride. NAD+ inhibits both Complex I-mediated and ammonium-stimulated H2O2 production. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=20170624 -- 4.7 Кб -- 02.02.2013
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342. Different neuronal Na(+)/K(+)-ATPase isoforms are involved in diverse signaling
... Different neuronal Na(+)/K(+)-ATPase isoforms are involved in diverse signaling pathways. ... Inhibition of rat neuronal Na(+)/K(+)-ATPase alpha3 isoform at low (100 nM) ouabain concentration led to activation of MAP kinase cascade via PKC and PIP(3) kinase. ... These data are the first demonstration showing participation of ouabain-resistant (alpha1) and ouabain-sensitive (alpha3) Na(+)/K(+)-ATPase isoforms in diverse signaling pathways in neuronal cells. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=20087845 -- 3.9 Кб -- 02.02.2013
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343. The taming of small heat-shock proteins: crystallization of the
... The taming of small heat-shock proteins: crystallization of the alpha-crystallin domain from human Hsp27. ... Small heat-shock proteins (sHsps) are ubiquitous molecular chaperones. sHsps function as homooligomers or heterooligomers that are prone to subunit exchange and structural plasticity. Here, a procedure for obtaining diffraction-quality crystals of the alpha-crystallin domain of human Hsp27 is presented. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=20054128 -- 4.1 Кб -- 02.02.2013
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344. Carnosine as a natural antioxidant and geroprotector: from molecular mechanisms
... Carnosine as a natural antioxidant and geroprotector: from molecular mechanisms to clinical trials. ... Carnosine is a neuroprotective dipeptide consisting of beta-alanine and L-histidine. ... Recently, carnosine was successfully used to treat patients after brain stroke or patients with Parkinson disease. We conclude that carnosine can be recommended for patients under oxidative stress as a natural remedy having high efficiency and no side effects. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=20017611 -- 4.0 Кб -- 02.02.2013
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345. The pivotal role of the beta 7 strand in the intersubunit contacts of different
... The pivotal role of the beta 7 strand in the intersubunit contacts of different human small heat shock proteins. ... It is concluded that the beta 7 strand participates in the intersubunit interaction of four human small heat shock proteins (alpha B-crystallin, HspB1, HspB6, HspB8) having different structure of beta2 strand of alpha-crystallin domain and different length and composition of variable N- and C-terminal tails. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=19856132 -- 4.5 Кб -- 02.02.2013
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346. Biological activity of novel synthetic derivatives of carnosine.
... Biological activity of novel synthetic derivatives of carnosine. ... Two novel derivatives of carnosine--(S)-trolox-L-carnosine (STC) and (R)-trolox-L-carnosine (RTC) are characterized in terms of their antioxidant and membrane-stabilizing activities as well as their resistance to serum carnosinase. ... At the same time, STC, RTC and trolox suppressed oxidative hemolysis of red blood cells (RBC) less efficiently than carnosine taken in the same concentration. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=19798566 -- 4.6 Кб -- 02.02.2013
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347. Death of ouabain-treated renal epithelial cells: evidence for p38 MAPK-mediated
... Death of ouabain-treated renal epithelial cells: evidence for p38 MAPK-mediated Na (i) (+) /K (i) (+) -independent signaling. ... Maximal increment of p38 phosphorylation was observed at 4 h followed by cell death at 12 h of ouabain addition. ... Both p38 phosphorylation and death of ouabain-treated C7-MDCK cells were suppressed by p38 inhibitor SB 202190 but were resistant to its inactive analogue SB 202474. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=19784777 -- 5.1 Кб -- 02.02.2013
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348. Thermally induced structural changes of intrinsically disordered small heat
... Thermally induced structural changes of intrinsically disordered small heat shock protein Hsp22. ... We applied different methods (differential scanning calorimetry, circular dichroism, Fourier transform infrared spectroscopy, and intrinsic fluorescence) to investigate the thermal-induced changes in the structure of small heat shock protein Hsp22. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=19783089 -- 4.1 Кб -- 02.02.2013
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349. Versatility of the small heat shock protein HSPB6 (Hsp20).
... Versatility of the small heat shock protein HSPB6 (Hsp20). ... 2010 May;15(3):233-6. doi: 10.1007/s12192-009-0141-x. Epub 2009 Sep 24. ... Cell Stress and Chaperones DOI 10.1007/s12192-0090127-8 ) dealing with the functional role of HSPB6 in muscle regulation is critically analyzed. ... All of these processes are dependent on HSPB6 phosphorylation which in turn might be regulated by the formation of heterooligomeric complexes of HSPB6 with other small heat shock proteins. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=19777375 -- 4.2 Кб -- 02.02.2013
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350. Phosphorylation of more than one site is required for tight interaction of
... Phosphorylation of more than one site is required for tight interaction of human tau protein with 14-3-3zeta. ... Serine residues phosphorylated by protein kinase A (PKA) in the shortest isoform of human tau protein (tau3) were sequentially replaced by alanine and interaction of phosphorylated tau3 and its mutants with 14-3-3 was investigated. ... Thus, two sites located in the Pro-rich region and in the pseudo repeats of tau3 are involved in phosphorylation-dependent interaction of tau3 with 14-3-3...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=19647741 -- 3.9 Кб -- 02.02.2013
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351. Assembly of a chimeric respiratory chain from bovine heart submitochondrial
... Assembly of a chimeric respiratory chain from bovine heart submitochondrial particles and cytochrome bd terminal oxidase of Escherichia coli. ... Cytochrome bd is a terminal quinol oxidase in Escherichia coli. ... Mixing purified cytochrome bd oxidase with myxothiazol-inhibited bovine heart submitochondrial particles (SMP) restores up to 50% of the original rotenone-sensitive NADH oxidase and succinate oxidase activities in the absence of exogenous ubiquinone analogs. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=19303413 -- 4.1 Кб -- 02.02.2013
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352. Processing of pro-brain natriuretic peptide is suppressed by O-glycosylation in
... Processing of pro-brain natriuretic peptide is suppressed by O-glycosylation in the region close to the cleavage site. ... RESULTS: Part of the proBNP molecule (amino acid residues 61-76) located near the cleavage site was inaccessible to specific MAbs because of the presence of O-glycans, whereas the same region in NT-proBNP was completely accessible. ... CONCLUSIONS: Only proBNP that was not glycosylated in the region of the cleavage site could effectively be processed into BNP and NT-proBNP. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=19168558 -- 5.2 Кб -- 02.02.2013
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353. Effect of phosphorylation on interaction of human tau protein with 14-3-3zeta.
... Effect of phosphorylation on interaction of human tau protein with 14-3-3zeta. ... Interaction of the shortest isoform of tau protein (tau3) with human 14-3-3zeta was analyzed by means of native gel electrophoresis, chemical crosslinking and size-exclusion chromatography. Phosphorylation by cAMP-dependent protein kinase (up to 2 mole of phosphate per mole of tau3) strongly enhanced interaction of tau3 with 14-3-3. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=19138662 -- 4.1 Кб -- 02.02.2013
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354. Heterooligomeric complexes formed by human small heat shock proteins HspB1
... Heterooligomeric complexes formed by human small heat shock proteins HspB1 (Hsp27) and HspB6 (Hsp20). ... Formation of heterooligomeric complexes of human small heat shock proteins (sHsp) HspB6 (Hsp20) and HspB1 (Hsp27) was analyzed by means of native gel electrophoresis, analytical ultracentrifugation, chemical cross-linking and size-exclusion chromatography. ... Inside of heterooligomeric complexes HspB6 inhibits phosphorylation of HspB1 by MAPKAP2 kinase. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=19100870 -- 4.8 Кб -- 02.02.2013
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355. Ammonium-dependent hydrogen peroxide production by mitochondria.
... Ammonium-dependent hydrogen peroxide production by mitochondria. ... 2008 Aug 6;582(18):2719-24. doi: 10.1016/j.febslet.2008.06.054. ... NADH-supported generation of H2O2 by permeabilized rat heart mitochondria was partially prevented by the specific complex I-directed inhibitor, NADH-OH, and was significantly stimulated by ammonium. ... The soluble mitochondrial matrix protein fraction catalyzed NADH-dependent H2O2 production, which was greatly (approximately 10-fold) stimulated by ammonium. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=18619961 -- 3.8 Кб -- 02.02.2013
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356. Novel immunoassay for quantification of brain natriuretic peptide and its
... Novel immunoassay for quantification of brain natriuretic peptide and its precursor in human blood. ... BACKGROUND: Brain natriuretic peptide (BNP) is an unstable molecule that can rapidly lose immunologic activity in blood. Conventional sandwich BNP immunoassays use 2 antibodies specific to 2 different epitopes. ... The purpose of our study was to develop a sandwich immunoassay for the precise quantification of BNP and BNP precursor (proBNP) in human blood that is not susceptible to proteolysis. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=18606632 -- 5.4 Кб -- 02.02.2013
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357. Effect of mutations mimicking phosphorylation on the structure and properties
... Effect of mutations mimicking phosphorylation on the structure and properties of human 14-3-3zeta. ... Effect of mutations mimicking phosphorylation on the structure of human 14-3-3zeta protein was analyzed by different methods. Mutation S58E increased intrinsic Trp fluorescence and binding of bis-ANS to 14-3-3. ... Thus, mutation mimicking phosphorylation of Ser58 destabilized, whereas mutation of Ser184 induced stabilization of 14-3-3zeta structure. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=18559254 -- 4.4 Кб -- 02.02.2013
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358. NADH/NAD+ interaction with NADH: ubiquinone oxidoreductase (complex I).
... NADH/NAD+ interaction with NADH: ubiquinone oxidoreductase (complex I). ... 2008 Jul-Aug;1777(7-8):729-34. doi: 10.1016/j.bbabio.2008.04.014. Epub 2008 Apr 18. ... The quantitative data on the binding affinity of NADH, NAD(+), and their analogues for complex I as emerged from the steady-state kinetics data and from more direct studies under equilibrium conditions are summarized and discussed. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=18471432 -- 3.5 Кб -- 02.02.2013
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359. Small heat shock protein Hsp27 protects myosin S1 from heat-induced
... Small heat shock protein Hsp27 protects myosin S1 from heat-induced aggregation, but not from thermal denaturation and ATPase inactivation. ... Upon heating at 43 degrees C, Hsp27 effectively suppresses S1 aggregation, and this effect is enhanced by mutations mimicking Hsp27 phosphorylation. However, Hsp27 was unable to prevent thermal unfolding of myosin heads and to maintain their ATPase activity under heat-shock conditions. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=18387368 -- 4.0 Кб -- 02.02.2013
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360. Immunodetection of glycosylated NT-proBNP circulating in human blood.
... Immunodetection of glycosylated NT-proBNP circulating in human blood. ... Recently it has been shown that proBNP is O-glycosylated in human blood. The goal of this study was to map sites on the NT-proBNP molecule that should be recognized by antibodies used in optimal NT-proBNP assays. METHODS: We analyzed endogenous NT-proBNP by several immunochemical methods using a broad panel of monoclonal antibodies specific to different epitopes of the NT-proBNP molecule. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=18339697 -- 5.1 Кб -- 02.02.2013
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