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401. Homocysteine and its derivatives as possible modulators of neuronal and
... Homocysteine and its derivatives as possible modulators of neuronal and non-neuronal cell glutamate receptors in Alzheimer's disease. ... Homocysteine (HC) and its derivatives may be involved in the etiology of Alzheimer's Disease (AD), although the precise mechanisms by which these compounds could cause cellular pathology are still unclear. ... These effects may contribute to the neuronal pathology and immunosenescence that occur in AD. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=17522446 -- 4.3 Кб -- 01.10.2012
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402. The brain natriuretic peptide (BNP) precursor is the major immunoreactive form
... The brain natriuretic peptide (BNP) precursor is the major immunoreactive form of BNP in patients with heart failure. ... BACKGROUND: Peptides derived from brain natriuretic peptide (BNP) precursor (proBNP), BNP, and the N-terminal fragment of proBNP (NT-proBNP) are used as biomarkers of heart failure. ... The mean proBNP:BNP ratio in patient plasma was 6.3, ranging from 1.8 to 10.8. CONCLUSIONS: ProBNP is the major BNP-immunoreactive form in human blood. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=17384012 -- 5.4 Кб -- 01.10.2012
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403. Effect of homocysteine and homocysteic acid on glutamate receptors on rat
... Effect of homocysteine and homocysteic acid on glutamate receptors on rat lymphocytes. ... Homocysteine and homocysteic acid increased the stationary level of reactive oxygen species in rat lymphocytes, homocysteic acid being more potent in this respect. The effect of this compound was realized via ionotropic NMDA receptors and group III metabotropic glutamate receptors. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=17369900 -- 3.7 Кб -- 01.10.2012
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404. Energy-linked binding of Pi is required for continuous steady-state
... Energy-linked binding of Pi is required for continuous steady-state proton-translocating ATP hydrolysis catalyzed by F0.F1 ATP synthase. ... The data are interpreted to suggest that coupled and uncoupled ATP hydrolysis catalyzed by Fo.F1 ATP synthases proceeds via different intermediates. ... Pi dissociates before ADP during uncoupled ATP hydrolysis, leaving the E.ADP intermediate which is transformed into the inactive ADP(Mg2+)-inhibited form of the enzyme (latent ATPase). ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=17128994 -- 4.7 Кб -- 01.10.2012
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405. Small heat shock protein Hsp20 (HspB6) as a partner of 14-3-3gamma.
... Small heat shock protein Hsp20 (HspB6) as a partner of 14-3-3gamma. ... Interaction of human 14-3-3gamma with the small heat shock protein Hsp20 was analyzed by means of size-exclusion chromatography and chemical crosslinking. Unphosphorylated Hsp20 and its mutant S16D mimicking phosphorylation by cAMP-dependent protein kinase did not interact with 14-3-3. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=17109079 -- 4.2 Кб -- 01.10.2012
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406. [Carnosine and relative compounds protect double-stranded DNA from oxidative
. Title: . [Carnosine and relative compounds protect double-stranded DNA from oxidative damage]. Authors: . Leinsoo TA; Abe H; Boldyrev AA . Publication: . Zh Evol Biokhim Fiziol. 2006 Sep-Oct;42(5):453-6. PubmedID . 17087009 . Abstract . None
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=17087009 -- 3.1 Кб -- 01.10.2012
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407. Structure and properties of K141E mutant of small heat shock protein HSP22
... Structure and properties of K141E mutant of small heat shock protein HSP22 (HspB8, H11) that is expressed in human neuromuscular disorders. ... Some properties of the K141E mutant of human HSP22 that is expressed in distal hereditary motor neuropathy were investigated. ... It is concluded that K141E mutation induces destabilization of HSP22 structure and probably by this means diminish the chaperone-like activity of HSP22 with certain protein substrates. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=16949546 -- 4.4 Кб -- 01.10.2012
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408. Carnosine protects from the oxidative stress induced by prenatal hypoxia.
. Title: . Carnosine protects from the oxidative stress induced by prenatal hypoxia. Authors: . Fedorova TN; Macletsova MG; Kulikov AV; Stepanova MS; Boldyrev AA . Publication: . Dokl Biol Sci. 2006 May-Jun;408:207-10. PubmedID . 16909979 . Abstract . None
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=16909979 -- 3.3 Кб -- 01.10.2012
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409. Cerebellar granule cell death induced by aluminum.
... Cerebellar granule cell death induced by aluminum. ... Using flow cytometry of acutely isolated cerebellar granule cell neurons, we have determined the effects of Al (III) on viability, membrane potential, intracellular calcium concentration and generation of reactive oxygen species (ROS). ... While exposure to Al (III) was accompanied by an increase in ROS and an elevation of intracellular calcium concentration, calcium chelators and ROS scavengers did not reduce cell death. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=16782589 -- 4.5 Кб -- 01.10.2012
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410. Topography and chemical reactivity of the active-inactive transition-sensitive
... Topography and chemical reactivity of the active-inactive transition-sensitive SH-group in the mitochondrial NADH:ubiquinone oxidoreductase (Complex I). ... Both NEM and DTNB rapidly inhibited the de-activated Complex I in SMP. In mitochondria NEM caused rapid inhibition of Complex I, whereas the enzyme activity was insensitive to DTNB. In the presence of the channel-forming antibiotic alamethicin, mitochondrial Complex I became sensitive to DTNB. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=16777054 -- 4.5 Кб -- 01.10.2012
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411. Glutamate receptors regulate the level of reactive oxygen species in neurons of
. Title: . Glutamate receptors regulate the level of reactive oxygen species in neurons of senescence accelerated mice (SAM) strain. Authors: . Kulikov AV; Boldyrev AA . Publication: . Dokl Biochem Biophys. 2006 Mar-Apr;407:106-8. PubmedID . 16776078 . Abstract . None
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=16776078 -- 3.2 Кб -- 01.10.2012
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412. Requirement of medium ADP for the steady-state hydrolysis of ATP by the
... Requirement of medium ADP for the steady-state hydrolysis of ATP by the proton-translocating Paracoccus denitrificans Fo.F1-ATP synthase. ... The half-maximal rate of stationary ATP hydrolysis is reached at an ADP concentration of 8 x 10(-6) M. The kinetic scheme is proposed explaining the requirement of the reaction products (ADP and Pi), the substrates of ATP synthesis, in the medium for proton-translocating ATP hydrolysis by P. denitrificans Fo.F1-ATP synthase. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=16730637 -- 4.4 Кб -- 01.10.2012
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413. [Levels of fatty acid binding protein before and after direct current
... Levels of fatty acid binding protein before and after direct current cardioversion of atrial fibrillation or flutter in patients without acute coronary syndrome]. ... CONCLUSION: Unexpectedly most pts with AF and atrial flutter had elevated FABP at baseline. ... AF, atrial flutter and DCC for these arrhythmias should be considered as sources of false positive results when FABP is used for diagnosis of acute myocardial infarction. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=16710255 -- 5.7 Кб -- 01.10.2012
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414. Generation of superoxide by the mitochondrial Complex I.
... Generation of superoxide by the mitochondrial Complex I. Authors: . ... Superoxide production by inside-out coupled bovine heart submitochondrial particles, respiring with succinate or NADH, was measured. ... Both NAD+ and acetyl-NAD+ inhibited the succinate-supported reaction with apparent Ki's close to their Km's in the Complex I-catalyzed succinate-dependent energy-linked NAD+ reduction (reverse electron transfer) and NADH:acetyl-NAD+ transhydrogenase reaction, respectively. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=16678117 -- 5.0 Кб -- 01.10.2012
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415. Erythrocyte and plasma protein modification in alcoholism: a possible role of
... Erythrocyte and plasma protein modification in alcoholism: a possible role of acetaldehyde. ... Analysis of the oxidative modification of plasma and erythrocyte ghost proteins of chronic alcoholic subjects and healthy non-alcoholics has been performed. It was found that increased levels of protein carbonyls in both plasma and erythrocyte ghosts from alcoholic subjects occurred in comparison to the levels found in preparations from non-alcoholics. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=16630710 -- 4.6 Кб -- 01.10.2012
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416. Functional coupling between nucleoside diphosphate kinase of the outer
... Functional coupling between nucleoside diphosphate kinase of the outer mitochondrial compartment and oxidative phosphorylation. ... In all three systems, muscle creatine phosphokinase was the external agent competing with the oxidative phosphorylation system for ADP. ... It is concluded that oxidative phosphorylation is accompanied by appearance of functional coupling between mitochondrial nucleoside diphosphate kinase and the oxidative phosphorylation system. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=16417458 -- 5.4 Кб -- 01.10.2012
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417. Protection of proteins from oxidative stress: a new illusion or a novel
... Protection of proteins from oxidative stress: a new illusion or a novel strategy? ... Proteins damaged by oxidative stress have the most dangerous consequences. ... Hydrophobic antioxidants are not very effective in protecting proteins from oxidative modification. At the same time, the natural hydrophilic antioxidant and anti-glycating agent carnosine efficiently prevents oxidative modification of proteins and increases the life span of experimental animals under unfavorable conditions. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=16399895 -- 3.7 Кб -- 01.10.2012
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418. Emerging evidence for a similar role of glutamate receptors in the nervous and
... Emerging evidence for a similar role of glutamate receptors in the nervous and immune systems. ... The role of glutamate receptors in synaptic transmission and excitotoxicity in the nervous system is well established. ... We conclude that glutamate is involved in signaling in immunocompetent cells and that the expression of both ionotropic and metabotropic glutamate receptors may have regulatory functions in immunocompetent cells, as well as in the nervous system. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=16271044 -- 4.5 Кб -- 01.10.2012
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419. Homocysteinic acid causes oxidative stress in lymphocytes by potentiating toxic
... Homocysteinic acid causes oxidative stress in lymphocytes by potentiating toxic effect of NMDA. ... The addition of homocysteinic acid in a nontoxic concentration of 100 microM potentiated the toxic effect of NMDA and led to massive cell death. ... Oxidative stress produced by these substances can result from activation of NMDA glutamate receptors that were recently detected on lymphocytes. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=16254614 -- 3.8 Кб -- 01.10.2012
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420. Small heat shock protein with apparent molecular mass 20 kDa (Hsp20, HspB6) is
... Small heat shock protein with apparent molecular mass 20 kDa (Hsp20, HspB6) is not a genuine actin-binding protein. ... The interaction of recombinant human small heat shock protein with apparent molecular mass 20 kDa (Hsp20, HspB6) with actin was investigated. ... Since Hsp20 is not a genuine actin-binding protein, the earlier described correlation between Hsp20 phosphorylation and smooth muscle relaxation cannot be explained by direct interaction of Hsp20 with actin. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=16205842 -- 4.2 Кб -- 01.10.2012
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