... A comparative study of thermodynamic for both natural and artificial RNA/DNA ­ protein complexes would establish bases for a specificity of complex formation. In particular, we have shown that aptamers could be used for a direct measuring of thrombin enzymatic activity in a solution. D 2002 Published by Elsevier Science B.V. Keywords: RNA/DNA ­ protein interactions; Ribosome; SELEX; RNA/DNA aptamers; Thrombin; Enzymatic activity 1. ... The aptamer binds to the protein with Kd = 0.5 nM. ...

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... Algorithm & . Format requirements . ... SDPsite is a tool for identification of protein active and other functional sites, based on spatial clustering of SDPs (specificity-determining positions, described here ) with CPs (conserved positions). ... Mapping predictied positions onto structure and construction of the best cluster . ... The input data of the algorithm are a multiple protein alignment divided into specificity groups . ... is called statistical significance of the set of k* positions . ...

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208. Department of Mathematics, Faculty of Physics, Lomonosov MSU

209. Notification mailing list

210. Super Ratio

211. http://www.ipib.msu.ru/UserFiles/File/spconf2010/talks/requena.doc

212. http://mailybaev.imec.msu.ru/papers/KliemEtAl2006.pdf

213. http://dbserv.sinp.msu.ru/apev/events/readme.txt

214. Moscow State University: Analytical Chemistry Division

215. Summer School 2016

216. The NMW survey homepage